Search Results - "Eaton JB"

Analogs of α-conotoxin PnIC selectively inhibit α7β2- over α7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.

Authors: George AA John SJ Lucero LM et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jan; Vol. 38 (1), pp. e23374.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons.

Authors: Chen D Gao F Ma X et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2019 Feb 14; Vol. 10, pp. 72. Date of Electronic Publication: 2019 Feb 14 (Print Publication: 2019).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes.

Authors: Kassner M Eaton JB Tang N et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Jan; Vol. 27 (1), pp. 68-76. Date of Electronic Publication: 2021 Oct 09.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol.

Authors: Gao F Chen D Ma X et al.

Source: Neuropharmacology [Neuropharmacology] 2019 May 01; Vol. 149, pp. 45-54. Date of Electronic Publication: 2019 Jan 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line.

Authors: Chen DJ Gao FF Ma XK et al.

Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2018 Oct; Vol. 39 (10), pp. 1571-1581. Date of Electronic Publication: 2018 May 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor.

Authors: Nichols AL Noridomi K Hughes CR et al.

Source: ACS chemical biology [ACS Chem Biol] 2018 Sep 21; Vol. 13 (9), pp. 2568-2576. Date of Electronic Publication: 2018 Aug 13.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists.

Authors: Zhang HK Eaton JB Fedolak A et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2016 Nov 29; Vol. 124, pp. 689-697. Date of Electronic Publication: 2016 Sep 09.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III.

Authors: Onajole OK Vallerini GP Eaton JB et al.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2016 Jun 15; Vol. 7 (6), pp. 811-22. Date of Electronic Publication: 2016 Apr 21.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

Differential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.

Authors: Lucero LM Weltzin MM Eaton JB et al.

Source: The Journal of biological chemistry [J Biol Chem] 2016 Jan 29; Vol. 291 (5), pp. 2444-59. Date of Electronic Publication: 2015 Dec 07.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.

Authors: Yu LF Zhang HK Caldarone BJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 2014 Oct 23; Vol. 57 (20), pp. 8204-23. Date of Electronic Publication: 2014 Jul 02.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.

Authors: Onajole OK Eaton JB Lukas RJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Sep 29; Vol. 5 (11), pp. 1196-201. Date of Electronic Publication: 2014 Sep 29 (Print Publication: 2014).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtype.

Authors: Eaton JB Lucero LM Stratton H et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Jan; Vol. 348 (1), pp. 46-58. Date of Electronic Publication: 2013 Nov 04.

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.

Authors: Zhang HK Yu LF Eaton JB et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Jul 11; Vol. 56 (13), pp. 5495-504. Date of Electronic Publication: 2013 Jun 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.

Authors: Yu LF Eaton JB Fedolak A et al.

Source: Journal of medicinal chemistry [J Med Chem] 2012 Nov 26; Vol. 55 (22), pp. 9998-10009. Date of Electronic Publication: 2012 Nov 02.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.

Authors: Zhang HK Eaton JB Yu LF et al.

Source: Journal of medicinal chemistry [J Med Chem] 2012 Sep 27; Vol. 55 (18), pp. 8028-37. Date of Electronic Publication: 2012 Sep 07.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.

Authors: Zhang H Tückmantel W Eaton JB et al.

Source: Journal of medicinal chemistry [J Med Chem] 2012 Jan 26; Vol. 55 (2), pp. 717-24. Date of Electronic Publication: 2012 Jan 10.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.

Authors: Yu LF Tückmantel W Eaton JB et al.

Source: Journal of medicinal chemistry [J Med Chem] 2012 Jan 26; Vol. 55 (2), pp. 812-23. Date of Electronic Publication: 2012 Jan 04.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.

Authors: Liu J Yu LF Eaton JB et al.

Source: Journal of medicinal chemistry [J Med Chem] 2011 Oct 27; Vol. 54 (20), pp. 7280-8. Date of Electronic Publication: 2011 Sep 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.

Authors: Carroll FI Muresan AZ Blough BE et al.

Source: Journal of medicinal chemistry [J Med Chem] 2011 Mar 10; Vol. 54 (5), pp. 1441-8. Date of Electronic Publication: 2011 Feb 14.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Nicotinic acetylcholine receptor efficacy and pharmacological properties of 3-(substituted phenyl)-2β-substituted tropanes.

Authors: Carroll FI Blough BE Mascarella SW et al.

Source: Journal of medicinal chemistry [J Med Chem] 2010 Dec 09; Vol. 53 (23), pp. 8345-53. Date of Electronic Publication: 2010 Nov 08.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE