Search Results - "Goate, Alison"

The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.

Authors: Liu, Haiyan Marsh, Thomas W Shi, Xinyu et al.

Source: Brain: A Journal of Neurology; Jul2025, Vol. 148 Issue 7, p2429-2440, 12p

MAOA-uVNTR and Early Physical Discipline Interact to Influence Delinquent Behavior

Authors: Edwards, Alexis C. Dodge, Kenneth A. Latendresse, Shawn J. et al.

Source: Journal of Child Psychology and Psychiatry. Jun 2010 51(6):679-687.

Peer Reviewed: Y

Page Count: 9

Descriptors: Check Lists, Discipline, Delinquency, Child Behavior, Statistical Significance, Punishment, Child Development, Genetics, Risk, Environmental Influences, Longitudinal Studies, Behavior Problems, Regression (Statistics), Aggression, Correlation, Males, Whites, Teacher Attitudes, Evaluation Methods, Measures (Individuals)

Assessment and Survey Identifiers: Conflict Tactics Scale, Child Behavior Checklist

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Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk.

Authors: Efthymiou, Anastasia G. Goate, Alison M.

Source: Molecular Neurodegeneration. 5/26/2017, Vol. 12, p1-12. 12p. 2 Diagrams, 1 Chart.

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.

Authors: Johnson, Emma C. Kapoor, Manav Hatoum, Alexander S. et al.

Source: Psychological Medicine. Mar2023, Vol. 53 Issue 4, p1196-1204. 9p.

Subjects: Statistics, Schizophrenia, Single nucleotide polymorphisms, Genetic variation, Gene expression, Alcohol drinking, Genomes, Data analysis, Mental illness, Phenotypes

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.

Authors: Leng, Kun Rose, Indigo V. L. Kim, Hyosung et al.

Source: Nature Neuroscience. Nov2022, Vol. 25 Issue 11, p1528-1542. 15p.

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology.

Authors: Morris, John C Weiner, Michael Xiong, Chengjie et al.

Source: Brain: A Journal of Neurology; Oct2022, Vol. 145 Issue 10, p3594-3607, 14p

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Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.

Authors: Ewers, Michael Luan, Ying Frontzkowski, Lukas et al.

Source: Brain: A Journal of Neurology; Jul2021, Vol. 144 Issue 7, p2176-2185, 10p

Multiple distinct CHRNB3- CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.

Authors: Culverhouse, Robert C. Johnson, Eric O. Breslau, Naomi et al.

Source: Addiction. May2014, Vol. 109 Issue 5, p814-822. 9p. 1 Diagram, 3 Charts.

Subjects: Drug addiction risk factors, Alcoholism, Black people, Cocaine, Confidence intervals, Epidemiology, Genes, Genetic polymorphisms, Nicotine, Race, Research funding, White people, Comorbidity, Logistic regression analysis, Data analysis, Case-control method, Data analysis software, Descriptive statistics

Geographic Terms: United States

Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene ( CYP2A6).

Authors: Chen, Li‐Shiun Bloom, A. Joseph Baker, Timothy B. et al.

Source: Addiction. Jan2014, Vol. 109 Issue 1, p128-137. 10p. 1 Chart, 4 Graphs.

Subjects: Nicotine metabolism, Drug therapy, Clinics, Confidence intervals, Pharmacogenomics, Research funding, Smoking cessation, Survival analysis (Biometry), Effect sizes (Statistics), Randomized controlled trials, Proportional hazards models

Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults.

Authors: Chorlian, David Rangaswamy, Madhavi Manz, Niklas et al.

Source: Behavior Genetics. Sep2013, Vol. 43 Issue 5, p386-401. 16p. 6 Charts.

Subjects: Neurophysiology, Genetics, Alcohol drinking, Underage drinking, Diseases in adults, Human genetic variation, Drugs of abuse

CHRNB3 is more strongly associated with Fagerström Test for Cigarette Dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

Authors: Rice, John P. Hartz, Sarah M. Agrawal, Arpana et al.

Source: Addiction. Nov2012, Vol. 107 Issue 11, p2019-2028. 10p.

Subjects: Drug addiction, Confidence intervals, Epidemiology, Genetic polymorphisms, Human genome, Meta-analysis, Nicotine, Research funding, Scales (Weighing instruments), Phenotypes, Logistic regression analysis, Data analysis, Secondary analysis, Data analysis software, Descriptive statistics, Genetics

Geographic Terms: United States

The Aggregate Effect of Dopamine Genes on Dependence Symptoms Among Cocaine Users: Cross-Validation of a Candidate System Scoring Approach.

Authors: Derringer, Jaime Krueger, Robert Dick, Danielle et al.

Source: Behavior Genetics. Jul2012, Vol. 42 Issue 4, p626-635. 10p. 2 Charts, 1 Graph.

Subjects: Dopamine, Cocaine, Lymphoblastoid cell lines, Interviewing, Psychometrics, Quantitative research, Physiology

Differential Susceptibility to Adolescent Externalizing Trajectories: Examining the Interplay Between CHRM2 and Peer Group Antisocial Behavior.

Authors: Latendresse, Shawn J. Bates, John E. Goodnight, Jackson A. et al.

Source: Child Development. Nov/Dec2011, Vol. 82 Issue 6, p1797-1814. 18p. 1 Diagram, 5 Charts, 2 Graphs.

Subjects: Externalism (Philosophy of mind), Acting out (Psychology), Sensitivity (Personality trait), Antisocial personality disorders, Peer relations, Delinquent behavior, Genetics, Psychology

Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence.

Authors: Chen, Li‐Shiun Johnson, Eric O. Breslau, Naomi et al.

Source: Addiction. Oct2009, Vol. 104 Issue 10, p1731-1740. 10p. 2 Charts, 2 Graphs.

Subjects: Genetic disorders, Nicotine addiction, Nicotinic receptors, Drug addiction, Substance abuse, Olfactory receptor genes, Genetic polymorphisms, Environmental risk assessment, Regression analysis, Genetics, Disease risk factors

Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

Authors: Agrawal, Arpana Pergadia, Michele L. Balasubramanian, Sumitra et al.

Source: Addiction. Mar2009, Vol. 104 Issue 3, p471-477. 7p. 3 Charts.

Subjects: Nicotine addiction, Genetic polymorphism research, Aminobutyric acid, Amino acids, Medical genetics, Neurotransmitter receptors

Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case–control study.

Authors: Agrawal, Arpana Pergadia, Michele L. Saccone, Scott F. et al.

Source: Addiction. Jun2008, Vol. 103 Issue 6, p1027-1038. 12p. 1 Diagram, 4 Charts.

Subjects: GABA receptors, Nicotine addiction, Genetic polymorphisms, Smoking, Drug addiction, Logistic regression analysis, Genetics

Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk.

Authors: Dick, Danielle M. Agrawal, Arpana Wang, Jen C. et al.

Source: Addiction. Jul2007, Vol. 102 Issue 7, p1131-1139. 9p. 1 Diagram, 2 Charts.

Subjects: Alcoholism, Drug addiction, People with alcoholism, Genetics, Acetylcholine, Muscarinic receptors, Mental illness, Pathological psychology, Psychological tests