Search Results - "Hedglin M"

Structure of the human CTF18-RFC clamp loader bound to PCNA.

Authors: Briola GR Tehseen M Al-Amodi A et al.

Source: ELife [Elife] 2026 Feb 23; Vol. 13. Date of Electronic Publication: 2026 Feb 23.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways.

Authors: Norris JL Rogers LO Young G et al.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Jan 05; Vol. 54 (1).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities.

Authors: Dannenberg RL Cardina JA Washington H et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Jul 08; Vol. 53 (13).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.

Authors: Hile SE Weissensteiner MH Pytko KG et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Fork Reversal Safeguards Epigenetic Inheritance During Replication Stress.

Authors: Wu Q Zhou C Dou Y et al.

Source: Research square [Res Sq] 2026 Jan 28. Date of Electronic Publication: 2026 Jan 28.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.

Authors: Sanford SL Badstübner M Gerber M et al.

Source: Nature communications [Nat Commun] 2025 Dec 07; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2025 Dec 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Structure of the human CTF18-RFC clamp loader bound to PCNA.

Authors: Briola GR Tehseen M Al-Amodi A et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 05. Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis.

Authors: Norris JL Rogers LO Pytko KG et al.

Source: Nucleic acids research [Nucleic Acids Res] 2024 Jul 22; Vol. 52 (13), pp. 7650-7664.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress.

Authors: Muoio D Laspata N Dannenberg RL et al.

Source: Nature communications [Nat Commun] 2024 Apr 02; Vol. 15 (1), pp. 2857. Date of Electronic Publication: 2024 Apr 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex.

Authors: Sanford SL Badstübner M Gerber M et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 27. Date of Electronic Publication: 2025 Jun 27.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.

Authors: Hoitsma NM Norris J Khoang TH et al.

Source: Nucleic acids research [Nucleic Acids Res] 2023 Jul 21; Vol. 51 (13), pp. 6738-6753.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways.

Authors: Norris JL Rogers LO Young G et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Apr 02. Date of Electronic Publication: 2025 Apr 02.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA.

Authors: Shin Y Hedglin M Murakami KS

Source: The Journal of biological chemistry [J Biol Chem] 2025 Apr; Vol. 301 (4), pp. 108342. Date of Electronic Publication: 2025 Feb 22.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities.

Authors: Dannenberg RL Cardina JA Pytko KG et al.

Source: Nucleic acids research [Nucleic Acids Res] 2022 Sep 23; Vol. 50 (17), pp. 9893-9908.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities.

Authors: Dannenberg RL Cardina JA Washington H et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels.

Authors: Pytko KG Dannenberg RL Eckert KA et al.

Source: Biochemistry [Biochemistry] 2024 Apr 16; Vol. 63 (8), pp. 969-983. Date of Electronic Publication: 2024 Mar 26.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Direct, ensemble FRET approaches to monitor transient state kinetics of human DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis.

Authors: Norris JL Hedglin M

Source: Methods in enzymology [Methods Enzymol] 2024; Vol. 705, pp. 271-309. Date of Electronic Publication: 2024 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

Replication of [AT/TA]25 microsatellite sequences by human DNA polymerase δ holoenzymes is dependent on dNTP and RPA levels.

Authors: Pytko KG Dannenberg RL Eckert KA et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 08. Date of Electronic Publication: 2023 Nov 08.

Publication Type: Preprint; Journal Article

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Stepwise requirements for polymerases δ and θ in theta-mediated end joining.

Authors: Stroik S Carvajal-Garcia J Gupta D et al.

Source: Nature [Nature] 2023 Nov; Vol. 623 (7988), pp. 836-841. Date of Electronic Publication: 2023 Nov 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.

Authors: Shin Y Hedglin M Murakami KS

Source: Nucleic acids research [Nucleic Acids Res] 2020 Feb 28; Vol. 48 (4), pp. 2144-2155.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE