Search Results - "Jacobs RT"

A 98-qubit trapped-ion quantum computer with all-to-all connectivity.

Authors: Ransford A Allman MS Arkinstall J et al.

Source: Nature [Nature] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

Authors: Ehrens A Lunde CS Jacobs RT et al.

Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jan 27; Vol. 14 (1), pp. e0007957. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.

Authors: Lunde CS Stebbins EE Jumani RS et al.

Source: Nature communications [Nat Commun] 2019 Jun 27; Vol. 10 (1), pp. 2816. Date of Electronic Publication: 2019 Jun 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.

Authors: Padilla AM Wang W Akama T et al.

Source: Nature microbiology [Nat Microbiol] 2022 Oct; Vol. 7 (10), pp. 1536-1546. Date of Electronic Publication: 2022 Sep 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads.

Authors: Butler MM Waidyarachchi SL Shao J et al.

Source: Molecular pharmacology [Mol Pharmacol] 2022 Sep; Vol. 102 (3), pp. 172-182. Date of Electronic Publication: 2022 Jul 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Authors: Zhang N Zoltner M Leung KF et al.

Source: PLoS pathogens [PLoS Pathog] 2018 Feb 09; Vol. 14 (2), pp. e1006850. Date of Electronic Publication: 2018 Feb 09 (Print Publication: 2018).

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.

Authors: Mowbray CE Braillard S Glossop PA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Nov 11; Vol. 64 (21), pp. 16159-16176. Date of Electronic Publication: 2021 Oct 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.

Authors: Pou S Dodean RA Frueh L et al.

Source: Organic process research & development [Org Process Res Dev] 2021 Aug 20; Vol. 25 (8), pp. 1841-1852. Date of Electronic Publication: 2021 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9890443 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1083-6160 (Print) Linking ISSN: 10836160 NLM ISO Abbreviation: Org Process Res Dev Subsets: PubMed not MEDLINE

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.

Authors: Priebbenow DL Mathiew M Shi DH et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 4150-4162. Date of Electronic Publication: 2021 Mar 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

Authors: Jacobs RT Nare B Wring SA et al.

Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Jun; Vol. 5 (6), pp. e1151. Date of Electronic Publication: 2011 Jun 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.

Authors: Carter DS Jacobs RT Freund YR et al.

Source: ACS infectious diseases [ACS Infect Dis] 2020 Feb 14; Vol. 6 (2), pp. 180-185. Date of Electronic Publication: 2020 Jan 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.

Authors: Akama T Freund YR Berry PW et al.

Source: ACS infectious diseases [ACS Infect Dis] 2020 Feb 14; Vol. 6 (2), pp. 173-179. Date of Electronic Publication: 2020 Jan 14.

Publication Type: Letter; Research Support, Non-U.S. Gov't

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Authors: Milano J McKay J Dagenais C et al.

Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2004 Nov; Vol. 82 (1), pp. 341-58. Date of Electronic Publication: 2004 Aug 19.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1096-6080 (Print) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

Authors: Jacobs RT Lunde CS Freund YR et al.

Source: Journal of medicinal chemistry [J Med Chem] 2019 Mar 14; Vol. 62 (5), pp. 2521-2540. Date of Electronic Publication: 2019 Feb 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.

Authors: Van Bocxlaer K Gaukel E Hauser D et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Apr 26; Vol. 62 (5). Date of Electronic Publication: 2018 Apr 26 (Print Publication: 2018).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).

Authors: Akama T Zhang YK Freund YR et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jan 01; Vol. 28 (1), pp. 6-10. Date of Electronic Publication: 2017 Nov 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

Authors: Zhang YK Plattner JJ Easom EE et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Jul 13; Vol. 60 (13), pp. 5889-5908. Date of Electronic Publication: 2017 Jun 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

Authors: Zhang YK Plattner JJ Easom EE et al.

Source: Journal of medicinal chemistry [J Med Chem] 2015 Jul 09; Vol. 58 (13), pp. 5344-54. Date of Electronic Publication: 2015 Jun 23.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.

Authors: Wu P Zhang J Meng Q et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2014 Jun 23; Vol. 81, pp. 59-75. Date of Electronic Publication: 2014 Apr 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.

Authors: Akama T Dong C Virtucio C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 5870-3. Date of Electronic Publication: 2013 Sep 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE