Search Results - "Kidger AM"

RAF inhibitors activate the integrated stress response by direct activation of GCN2.

Authors: Gilley R Kidger AM Neill G et al.

Source: Nature communications [Nat Commun] 2025 Nov 17; Vol. 16 (1), pp. 10033. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

Authors: Balmanno K Kidger AM Byrne DP et al.

Source: The Biochemical journal [Biochem J] 2023 May 15; Vol. 480 (9), pp. 587-605.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy.

Authors: Ferguson BS Wennersten SA Demos-Davies KM et al.

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2021 Aug 01; Vol. 321 (2), pp. H382-H389. Date of Electronic Publication: 2021 Jun 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.

Authors: Lochhead PA Tucker JA Tatum NJ et al.

Source: Nature communications [Nat Commun] 2020 Mar 13; Vol. 11 (1), pp. 1383. Date of Electronic Publication: 2020 Mar 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif.

Authors: Kidger AM Cook SJ

Source: The FEBS journal [FEBS J] 2018 Jan; Vol. 285 (1), pp. 42-45.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Comment

Journal Info: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

Suppression of mutant Kirsten-RAS (KRAS^G12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.

Authors: Kidger AM Saville MK Rushworth LK et al.

Source: Oncogene [Oncogene] 2022 May; Vol. 41 (20), pp. 2811-2823. Date of Electronic Publication: 2022 Apr 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2.

Authors: Kidger AM Munck JM Saini HK et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Feb; Vol. 19 (2), pp. 525-539. Date of Electronic Publication: 2019 Nov 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Authors: Odle RI Walker SA Oxley D et al.

Source: Molecular cell [Mol Cell] 2020 Jan 16; Vol. 77 (2), pp. 228-240.e7. Date of Electronic Publication: 2019 Nov 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Dual-specificity MAP kinase phosphatases in health and disease.

Authors: Seternes OM Kidger AM Keyse SM

Source: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Jan; Vol. 1866 (1), pp. 124-143. Date of Electronic Publication: 2018 Sep 08.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway.

Authors: Kidger AM Sipthorp J Cook SJ

Source: Pharmacology & therapeutics [Pharmacol Ther] 2018 Jul; Vol. 187, pp. 45-60. Date of Electronic Publication: 2018 Feb 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-016X (Electronic) Linking ISSN: 01637258 NLM ISO Abbreviation: Pharmacol Ther Subsets: MEDLINE

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Authors: Sipthorp J Lebraud H Gilley R et al.

Source: Bioconjugate chemistry [Bioconjug Chem] 2017 Jun 21; Vol. 28 (6), pp. 1677-1683. Date of Electronic Publication: 2017 May 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.

Authors: Kidger AM Rushworth LK Stellzig J et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jan 17; Vol. 114 (3), pp. E317-E326. Date of Electronic Publication: 2017 Jan 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs).

Authors: Kidger AM Keyse SM

Source: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2016 Feb; Vol. 50, pp. 125-32. Date of Electronic Publication: 2016 Jan 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE

Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs).

Authors: Caunt CJ Kidger AM Keyse SM

Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2016; Vol. 1447, pp. 197-215.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.

Authors: Rushworth LK Kidger AM Delavaine L et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Dec 23; Vol. 111 (51), pp. 18267-72. Date of Electronic Publication: 2014 Dec 08.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE