Search Results - "Kinberger GA"

Divalent siRNA for prion disease.

Authors: Gentile JE Corridon TL Serack FE et al.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 23; Vol. 54 (8).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.

Authors: Valencia T Yen LY Berman C et al.

Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10762. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Distribution of divalent small interfering RNA into neurons of sensory ganglia produces selective, durable knockdown of Nav1.7 and strong analgesia.

Authors: Gallant-Behm CL Siemian JN Tran D et al.

Source: Pain [Pain] 2026 May 20. Date of Electronic Publication: 2026 May 20.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE

Durable suppression of seizures in a preclinical model of KCNT1 genetic epilepsy with divalent small interfering RNA.

Authors: Andreone BJ Lin J Tocci J et al.

Source: Epilepsia [Epilepsia] 2025 May; Vol. 66 (5), pp. 1677-1690. Date of Electronic Publication: 2025 Jan 27.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Divalent siRNA for prion disease.

Authors: Gentile JE Corridon TL Serack FE et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 05. Date of Electronic Publication: 2026 Mar 05.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.

Authors: Driscoll R Hampton L Abraham NA et al.

Source: Scientific reports [Sci Rep] 2024 Jan 24; Vol. 14 (1), pp. 2061. Date of Electronic Publication: 2024 Jan 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates.

Authors: Østergaard ME Jackson M Low A et al.

Source: Nucleic acids research [Nucleic Acids Res] 2019 Jul 09; Vol. 47 (12), pp. 6045-6058.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5'-Vinylphosphonate.

Authors: Nikan M Li W Kinberger GA et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2019 Jan 09; Vol. 24 (2). Date of Electronic Publication: 2019 Jan 09.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes.

Authors: Tanowitz M Hettrick L Revenko A et al.

Source: Nucleic acids research [Nucleic Acids Res] 2017 Dec 01; Vol. 45 (21), pp. 12388-12400.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

Authors: Schmidt K Prakash TP Donner AJ et al.

Source: Nucleic acids research [Nucleic Acids Res] 2017 Mar 17; Vol. 45 (5), pp. 2294-2306.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.

Authors: Liang XH Shen W Sun H et al.

Source: Nucleic acids research [Nucleic Acids Res] 2016 May 05; Vol. 44 (8), pp. 3892-907. Date of Electronic Publication: 2016 Mar 03.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.

Authors: Prakash TP Lima WF Murray HM et al.

Source: Nucleic acids research [Nucleic Acids Res] 2015 Mar 31; Vol. 43 (6), pp. 2993-3011. Date of Electronic Publication: 2015 Mar 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.

Authors: Prakash TP Yu J Kinberger GA et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3774-3779. Date of Electronic Publication: 2018 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity.

Authors: Prakash TP Lima WF Murray HM et al.

Source: Nucleic acids research [Nucleic Acids Res] 2017 Jun 20; Vol. 45 (11), pp. 6994.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: PubMed not MEDLINE

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Authors: Kinberger GA Prakash TP Yu J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 01; Vol. 26 (15), pp. 3690-3. Date of Electronic Publication: 2016 May 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.

Authors: Schirle NT Kinberger GA Murray HF et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2016 Jul 20; Vol. 138 (28), pp. 8694-7. Date of Electronic Publication: 2016 Jul 12.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Authors: Prakash TP Kinberger GA Murray HM et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Jun 15; Vol. 26 (12), pp. 2817-2820. Date of Electronic Publication: 2016 Apr 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.

Authors: Migawa MT Prakash TP Vasquez G et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 May 01; Vol. 26 (9), pp. 2194-7. Date of Electronic Publication: 2016 Mar 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

Authors: Prakash TP Yu J Migawa MT et al.

Source: Journal of medicinal chemistry [J Med Chem] 2016 Mar 24; Vol. 59 (6), pp. 2718-33. Date of Electronic Publication: 2016 Mar 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

Authors: Prakash TP Brad Wan W Low A et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Oct 01; Vol. 25 (19), pp. 4127-30. Date of Electronic Publication: 2015 Aug 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE