Search Results - "Macrocyclic compounds"

Divergent and programmable skeletal remodeling of complex macrocycles with a small method set.

Authors: Nikbakht A Li X Wan J et al.

Source: Science (New York, N.Y.) [Science] 2026 May 21; Vol. 392 (6800), pp. eaee3540. Date of Electronic Publication: 2026 May 21.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide.

Authors: Klapars A Fryszkowska A Galanie S et al.

Source: Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. 643-647. Date of Electronic Publication: 2026 May 07.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Synthesis of Indoline-Fused Macrocycles via Photocatalytic Dearomatization of Indoles.

Authors: Lei Z Wei H Zhang Q et al.

Source: Organic letters [Org Lett] 2026 Jun 26; Vol. 28 (25), pp. 7953-7958. Date of Electronic Publication: 2026 Jun 11.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Larock Indolization of Chloroanilines for the Synthesis of Noncanonical Tryptophans and Macrocyclic Compounds.

Authors: Valencia OL Nguyen VD

Source: The Journal of organic chemistry [J Org Chem] 2026 Jun 19; Vol. 91 (24), pp. 8403-8408. Date of Electronic Publication: 2026 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.

Authors: Gan SX Zhang RL Guo C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13966-13979. Date of Electronic Publication: 2026 May 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

The application of the pillararene-based GSH depletion strategy in tumor therapy.

Authors: Liu Y Liu M Xie S et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Jun 11; Vol. 62 (45), pp. 11273-11284. Date of Electronic Publication: 2026 Jun 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Mitigating Excessive Mitochondrial Fission Through the Development of a Selective Macrocyclic Inhibitor Targeting Fis1/Mid51 Signaling.

Authors: Zerihun M Chakraborty S Abita A et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13380-13403. Date of Electronic Publication: 2026 May 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation.

Authors: Phillips DP Alper PB Cho CY et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13165-13187. Date of Electronic Publication: 2026 May 19.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Cationic imidazolium macrocycles enable array-based, site-selective optical detection of peptide phosphorylation.

Authors: Garcia AC Lian R Fasihianifard P et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2026 Jun 10; Vol. 24 (22), pp. 4731-4738. Date of Electronic Publication: 2026 Jun 10.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

o-Terphenyl-Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin.

Authors: Ghule S Sarkar S Rodriguez MEP et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 Jun 08; Vol. 65 (24), pp. e25972. Date of Electronic Publication: 2026 Mar 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

On-Resin Synthesis and Diversification of Macrocyclic Disulfide Bridge Peptidomimetics via Bifunctional 5-Iodo-1,4-Triazoles.

Authors: Malone MA Shepperson OA Simms JE et al.

Source: The Journal of organic chemistry [J Org Chem] 2026 Jun 05; Vol. 91 (22), pp. 7416-7422. Date of Electronic Publication: 2026 May 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

Three New HHDP-Bridged Macrocyclic Polyphenols With FXR Agonistic Activity From Penthorum chinense Pursh.

Authors: Lu Y Lu S Chen C et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2026 Jun; Vol. 23 (6), pp. e02975.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Inter- vs Intramolecular Aldehyde-Alkyne-Amine A³-Reaction in the Solution-Phase Synthesis of a Potent Macrocyclic Azapeptide CD36 Modulator.

Authors: Maarouf-Mesli N Fonseca JC Harvey SM et al.

Source: The Journal of organic chemistry [J Org Chem] 2026 May 08; Vol. 91 (18), pp. 6495-6501. Date of Electronic Publication: 2026 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins.

Authors: Wayama T Horinouchi R Arai M et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 May 07; Vol. 62 (35), pp. 9011-9015. Date of Electronic Publication: 2026 May 07.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Branching beyond bifunctional linkers: synthesis of macrocyclic and trivalent PROTACs.

Authors: Cao Y Harris AL Ciulli A

Source: Nature protocols [Nat Protoc] 2026 May; Vol. 21 (5), pp. 2328-2363. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Chemoselective C-Terminal Activation Platform for Direct Conversion of Native Linear Peptides into Thiazoline/Thiazole Macrocycles.

Authors: Le BQG Kwon M Raj M

Source: Organic letters [Org Lett] 2026 May 01; Vol. 28 (17), pp. 5466-5470. Date of Electronic Publication: 2026 Apr 16.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Bridging Heterocycle-Mediated Hydrogen Bonding Facilitates Permeability of Polar Macrobicycles.

Authors: Cooper GID Dai B Durham N et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Apr 29; Vol. 148 (16), pp. 17025-17034. Date of Electronic Publication: 2026 Apr 15.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides.

Authors: Wall BJ Chaudhury U Sharma KK et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Apr 22; Vol. 148 (15), pp. 16482-16492. Date of Electronic Publication: 2026 Apr 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

RaPID Selection of α-Hydrazino Acid-Containing Macrocyclic Peptides.

Authors: Matsumoto S Katoh T Suga H

Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Apr 22; Vol. 148 (15), pp. 15919-15929. Date of Electronic Publication: 2026 Apr 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Coordination-driven supramolecular metalla-cycles/cages for next-generation antibacterial therapy.

Authors: Cheng YH Jia PP Jin TX et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Apr 21; Vol. 62 (30), pp. 7665-7679. Date of Electronic Publication: 2026 Apr 21.

Publication Type: Journal Article; Review

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE