Search Results - "Pappalardi MB"

Asymmetric synthesis of potent and orally bioavailable thiophene-based EZH2 inhibitors.

Authors: Tian X Newlander K LaFrance L et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Nov 01; Vol. 127, pp. 130291. Date of Electronic Publication: 2025 May 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.

Authors: Jiang Q Braun DA Clauser KR et al.

Source: Cell [Cell] 2025 Apr 03; Vol. 188 (7), pp. 1807-1827.e34. Date of Electronic Publication: 2025 Feb 28.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation.

Authors: Ge AY Arab A Dai R et al.

Source: Scientific reports [Sci Rep] 2024 Oct 29; Vol. 14 (1), pp. 25940. Date of Electronic Publication: 2024 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.

Authors: Patel AJ Warda S Maag JLV et al.

Source: Cancer discovery [Cancer Discov] 2022 Sep 02; Vol. 12 (9), pp. 2120-2139.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.

Authors: Horton JR Pathuri S Wong K et al.

Source: Structure (London, England : 1993) [Structure] 2022 Jun 02; Vol. 30 (6), pp. 793-802.e5. Date of Electronic Publication: 2022 Apr 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1.

Authors: Wiseman AK Tiedemann RL Fan H et al.

Source: Communications biology [Commun Biol] 2022 Jun 02; Vol. 5 (1), pp. 528. Date of Electronic Publication: 2022 Jun 02.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Authors: Pappalardi MB Keenan K Cockerill M et al.

Source: Nature cancer [Nat Cancer] 2021 Oct; Vol. 2 (10), pp. 1002-1017. Date of Electronic Publication: 2021 Sep 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer

Dnmt1 has de novo activity targeted to transposable elements.

Authors: Haggerty C Kretzmer H Riemenschneider C et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Jul; Vol. 28 (7), pp. 594-603. Date of Electronic Publication: 2021 Jun 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.

Authors: Su DS Qu J Schulz M et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Dec 27; Vol. 11 (2), pp. 133-140. Date of Electronic Publication: 2019 Dec 27 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Authors: Fedoriw A Rajapurkar SR O'Brien S et al.

Source: Cancer cell [Cancer Cell] 2019 Jul 08; Vol. 36 (1), pp. 100-114.e25. Date of Electronic Publication: 2019 Jun 27.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.

Authors: Smitheman KN Severson TM Rajapurkar SR et al.

Source: Haematologica [Haematologica] 2019 Jun; Vol. 104 (6), pp. 1156-1167. Date of Electronic Publication: 2018 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.

Authors: Gerhart SV Kellner WA Thompson C et al.

Source: Scientific reports [Sci Rep] 2018 Jun 26; Vol. 8 (1), pp. 9711. Date of Electronic Publication: 2018 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

Authors: Mohammad HP Smitheman KN Kamat CD et al.

Source: Cancer cell [Cancer Cell] 2015 Jul 13; Vol. 28 (1), pp. 57-69.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.

Authors: Ott HM Graves AP Pappalardi MB et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Dec; Vol. 13 (12), pp. 3062-73. Date of Electronic Publication: 2014 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.

Authors: Van Aller GS Pappalardi MB Ott HM et al.

Source: ACS chemical biology [ACS Chem Biol] 2014 Mar 21; Vol. 9 (3), pp. 622-9. Date of Electronic Publication: 2013 Dec 31.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.

Authors: Diaz E Machutta CA Chen S et al.

Source: Journal of biomolecular screening [J Biomol Screen] 2012 Dec; Vol. 17 (10), pp. 1279-92. Date of Electronic Publication: 2012 Aug 17.

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).

Authors: McCabe MT Graves AP Ganji G et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Feb 21; Vol. 109 (8), pp. 2989-94. Date of Electronic Publication: 2012 Feb 08.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Authors: Pappalardi MB McNulty DE Martin JD et al.

Source: The Biochemical journal [Biochem J] 2011 Jun 01; Vol. 436 (2), pp. 363-9.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.

Authors: Pappalardi MB Martin JD Jiang Y et al.

Source: Biochemistry [Biochemistry] 2008 Oct 28; Vol. 47 (43), pp. 11165-7. Date of Electronic Publication: 2008 Oct 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.

Authors: Luo L Pappalardi MB Tummino PJ et al.

Source: Analytical biochemistry [Anal Biochem] 2006 Jun 01; Vol. 353 (1), pp. 69-74. Date of Electronic Publication: 2006 Apr 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0003-2697 (Print) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE