Search Results - "Rabeh WM"

Identification of a Quinolone-Based Scaffold as a Dual SARS-COV-2 PLᵖʳᵒ and Mᵖʳᵒ Inhibitor: An Integrated Molecular Modeling and In-vitro Evaluation Approach.

Authors: Atatreh N Bustanji L Ferreira JC et al.

Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 May 04; Vol. 20, pp. 593126. Date of Electronic Publication: 2026 May 04 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Mapping the structural dynamics of red- and blue-emitting beetle luciferases revealed by HDX-MS.

Authors: Kharbatli AR Ferreira JC Lui NM et al.

Source: Life science alliance [Life Sci Alliance] 2025 Oct 23; Vol. 9 (1). Date of Electronic Publication: 2025 Oct 23 (Print Publication: 2026).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation.

Authors: Dian AL Fabbri L Moya-Plana A et al.

Source: PLoS biology [PLoS Biol] 2025 Sep 16; Vol. 23 (9), pp. e3003364. Date of Electronic Publication: 2025 Sep 16 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Residues of the ribose binding site are required for human ribokinase activity.

Authors: Ferreira JC Nedyalkova L Villanueva AJ et al.

Source: Journal of structural biology: X [J Struct Biol X] 2025 Oct 28; Vol. 12, pp. 100137. Date of Electronic Publication: 2025 Oct 28 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101761384 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1524 (Electronic) Linking ISSN: 25901524 NLM ISO Abbreviation: J Struct Biol X Subsets: PubMed not MEDLINE

Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro.

Authors: Ferreira JC Fadl S Cardoso THS et al.

Source: Bioscience reports [Biosci Rep] 2024 Aug 28; Vol. 44 (8).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

3-chymotrypsin-like protease in SARS-CoV-2.

Authors: Al Adem K Ferreira JC Villanueva AJ et al.

Source: Bioscience reports [Biosci Rep] 2024 Aug 28; Vol. 44 (8).

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

The Discovery of Novel Small Oxindole-Based Inhibitors Targeting the SARS-CoV-2 Main Protease (M^pro ).

Authors: Alzyoud L Mahgoub RE Mohamed FE et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2023 Nov; Vol. 20 (11), pp. e202301176. Date of Electronic Publication: 2023 Nov 09.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2.

Authors: Shetler CL Ferreira JC Cardoso THS et al.

Source: The Biochemical journal [Biochem J] 2022 Oct 28; Vol. 479 (20), pp. 2175-2193.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation.

Authors: Mahgoub RE Mohamed FE Alzyoud L et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 09; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Identification of novel allosteric sites of SARS-CoV-2 papain-like protease (PLpro) for the development of COVID-19 antivirals.

Authors: Ferreira JC Villanueva AJ Al Adem K et al.

Source: The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107821. Date of Electronic Publication: 2024 Sep 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Residues in the fructose-binding pocket are required for ketohexokinase-A activity.

Authors: Ferreira JC Villanueva AJ Fadl S et al.

Source: The Journal of biological chemistry [J Biol Chem] 2024 Aug; Vol. 300 (8), pp. 107538. Date of Electronic Publication: 2024 Jul 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro.

Authors: Ferreira JC Fadl S Ilter M et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21774.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (M^pro) through pharmacophore modelling, covalent docking, and biological evaluation.

Authors: Mahgoub RE Mohamed FE Ali BR et al.

Source: Journal of molecular graphics & modelling [J Mol Graph Model] 2024 Mar; Vol. 127, pp. 108672. Date of Electronic Publication: 2023 Nov 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science, Inc Country of Publication: United States NLM ID: 9716237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4243 (Electronic) Linking ISSN: 10933263 NLM ISO Abbreviation: J Mol Graph Model Subsets: MEDLINE

SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses.

Authors: Saksena NK Reddy SB Miranda-Saksena M et al.

Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Dec; Vol. 1869 (8), pp. 166836. Date of Electronic Publication: 2023 Aug 05.

Publication Type: Review; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

Key Allosteric and Active Site Residues of SARS-CoV-2 3CLpro Are Promising Drug Targets.

Authors: Al Adem K Ferreira JC Fadl S et al.

Source: The Biochemical journal [Biochem J] 2023 May 31. Date of Electronic Publication: 2023 May 31.

Publication Type: Journal Article

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity.

Authors: Al Adem K Ferreira JC Fadl S et al.

Source: The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102790. Date of Electronic Publication: 2022 Dec 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.

Authors: Nawaz MH Ferreira JC Nedyalkova L et al.

Source: Bioscience reports [Biosci Rep] 2018 Feb 21; Vol. 38 (1). Date of Electronic Publication: 2018 Feb 21 (Print Publication: 2018).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2.

Authors: Ferreira JC Fadl S Rabeh WM

Source: The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 102023. Date of Electronic Publication: 2022 May 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells.

Authors: Woldetsadik AD Vogel MC Rabeh WM et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2017 May; Vol. 31 (5), pp. 2168-2184. Date of Electronic Publication: 2017 Feb 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease.

Authors: Ferreira JC Fadl S Villanueva AJ et al.

Source: Frontiers in chemistry [Front Chem] 2021 Jun 24; Vol. 9, pp. 692168. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE