Search Results - "Smutny T"

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LP-48: Temporal gene expression changes in xenobiotic-handling genes after constitutive androstane receptor activation in a model of 3D primary human hepatocytes.

Authors: Smutny, T. Smutna, L. Pavek, P.

Source: Toxicology Letters. 2023 Supplement 1, Vol. 384, pS319-S320. 2p.

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Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression.

Authors: Ahonen MH Konzack A Smutny T et al.

Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2026 Apr; Vol. 138 (4), pp. e70218.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin Pharmacol Toxicol Subsets: MEDLINE

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.

Authors: Dusek J Mejdrová I Dohnalová K et al.

Source: Nature communications [Nat Commun] 2025 Feb 06; Vol. 16 (1), pp. 1418. Date of Electronic Publication: 2025 Feb 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.

Authors: Kamaraj R Mejdrová I Krutakova M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 24; Vol. 68 (14), pp. 14271-14299. Date of Electronic Publication: 2025 Jul 12.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver.

Authors: Konzack A Karpale M Smutny T et al.

Source: Molecular pharmacology [Mol Pharmacol] 2025 Mar; Vol. 107 (3), pp. 100019. Date of Electronic Publication: 2025 Feb 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes.

Authors: Smutny T Smutna L Lochman L et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Nov; Vol. 229, pp. 116500. Date of Electronic Publication: 2024 Aug 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Authors: Smutny T Bernhauerova V Smutna L et al.

Source: Archives of toxicology [Arch Toxicol] 2022 Jan; Vol. 96 (1), pp. 195-210. Date of Electronic Publication: 2021 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.

Authors: Durinova A Smutna L Barta P et al.

Source: EJNMMI radiopharmacy and chemistry [EJNMMI Radiopharm Chem] 2024 Apr 18; Vol. 9 (1), pp. 32. Date of Electronic Publication: 2024 Apr 18.

Publication Type: Journal Article

Journal Info: Publisher: Springer Open Country of Publication: England NLM ID: 101714628 Publication Model: Electronic Cited Medium: Internet ISSN: 2365-421X (Electronic) Linking ISSN: 2365421X NLM ISO Abbreviation: EJNMMI Radiopharm Chem Subsets: PubMed not MEDLINE

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Authors: Smutny T Hyrsova L Braeuning A et al.

Source: Archives of toxicology [Arch Toxicol] 2021 Jan; Vol. 95 (1), pp. 11-25. Date of Electronic Publication: 2020 Nov 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Authors: Hendriks DFG Vorrink SU Smutny T et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Oct; Vol. 108 (4), pp. 844-855. Date of Electronic Publication: 2020 May 22.

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.

Authors: Mejdrová I Dušek J Škach K et al.

Source: Journal of medicinal chemistry [J Med Chem] 2023 Feb 23; Vol. 66 (4), pp. 2422-2456. Date of Electronic Publication: 2023 Feb 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.

Authors: Carazo A Dusek J Holas O et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2018 Oct 11; Vol. 9, pp. 993. Date of Electronic Publication: 2018 Oct 11 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation.

Authors: Hyrsova L Smutny T Trejtnar F et al.

Source: Drug metabolism reviews [Drug Metab Rev] 2016 May; Vol. 48 (2), pp. 139-58. Date of Electronic Publication: 2016 Jun 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0322067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9883 (Electronic) Linking ISSN: 03602532 NLM ISO Abbreviation: Drug Metab Rev Subsets: MEDLINE

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.

Authors: Hyrsova L Smutny T Carazo A et al.

Source: British journal of pharmacology [Br J Pharmacol] 2016 May; Vol. 173 (10), pp. 1703-15. Date of Electronic Publication: 2016 Apr 08.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.

Authors: Skoda J Dusek J Drastik M et al.

Source: Cells [Cells] 2020 Nov 24; Vol. 9 (12). Date of Electronic Publication: 2020 Nov 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism.

Authors: Stefela A Kaspar M Drastik M et al.

Source: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Sep; Vol. 202, pp. 105702. Date of Electronic Publication: 2020 Jun 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

Authors: Smutny T Bitman M Urban M et al.

Source: Archives of toxicology [Arch Toxicol] 2014 Dec; Vol. 88 (12), pp. 2243-59. Date of Electronic Publication: 2014 May 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.

Authors: Pavek P Smutny T

Source: Drug metabolism reviews [Drug Metab Rev] 2014 Feb; Vol. 46 (1), pp. 19-32. Date of Electronic Publication: 2013 Sep 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0322067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9883 (Electronic) Linking ISSN: 03602532 NLM ISO Abbreviation: Drug Metab Rev Subsets: MEDLINE