Search Results - "Structure-activity relationships"

Scanning nitrogen in sp³-rich scaffolds enabled by carbonyl-to-nitrogen atom swap.

Authors: Zhang, Zining Liang, Zhehan Ye, Rong et al.

Source: Science. 4/30/2026, Vol. 392 Issue 6797, p536-542. 7p.

Three-component assembly and structure-function relationships of (–)-gukulenin A.

Authors: Gupta, Vaani Wang, Zechun Combs, Joshua B. et al.

Source: Science. 12/11/2025, Vol. 390 Issue 6778, p1-9. 9p.

Antibacterial and structure-activity relationship of benzoic acid and its derivatives.

Authors: Singh, Keisham Sarjit Devi, Prabha Wahidullah, Solimabi

Source: Current Science (00113891). 5/10/2026, Vol. 130 Issue 9, p843-846. 4p.

Subjects: Benzoic acid, Structure-activity relationships, Antibacterial agents, Pharmacology, Food preservatives, Molecules, Chemical structure

Editorial: Bioactive natural products for health: isolation, structural elucidation, biological evaluation, structure-activity relationship, and mechanism, volume II.

Authors: Ma, Qin-Ge Liu, Wen-Min Geng, Zhao et al.

Source: Frontiers in Chemistry. 2026, p1-4. 4p.

Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine.

Authors: Elebiju, Oluwadunni F. Ajani, Olayinka O. Oduselu, Gbolahan O. et al.

Source: Frontiers in Chemistry. 2026, p1-18. 18p.

Dihydrosanguinarine: A Review of Its Pharmacology, Structure–Activity Relationship, Toxicity, Pharmacokinetics, and Clinical Prospects.

Authors: Yin, Xiaoqi Cao, Yingyi Fang, Chuxuan et al.

Source: International Journal of Molecular Sciences. Jun2026, Vol. 27 Issue 11, p4852. 25p.

Synthesis, structure–activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3- b ]pyridines as PIKfyve inhibitors.

Authors: Gao, Ling-Jie Kalebic, Demian Lo, Chieh Wen et al.

Source: Frontiers in Chemistry. 2026, p1-21. 21p.

Structure–Activity Relationship Analysis of Flavonoids Isolated from the Leaves of Erythroxylum rimosum O. E. Schulz.

Authors: dos Santos, Ivana P. Costa, Maria Eduarda V. de Oliveira, Geovana A. et al.

Source: Molecules. May2026, Vol. 31 Issue 10, p1669. 17p.

Jacareubin Derivatives Increase Their Anti-Allergic Activity.

Authors: Tavera-Hernández, Rosario Pérez-Rodríguez, Jesabel Nieto-Camacho, Antonio et al.

Source: Molecules. May2026, Vol. 31 Issue 10, p1666. 21p.

Structure-Function Correlations of Commercial Fucoidan Extracts: Antioxidant, Antiviral, Antifungal, Antibacterial and Prebiotic Activities.

Authors: Chadwick, Matthew Lancerin, Maria Sole Regina Hazelton, Patricia et al.

Source: Molecules. May2026, Vol. 31 Issue 10, p1618. 26p.

P-Selectin Inhibition and the Structure–Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides.

Authors: Li, Sujuan Lin, Lisha Yang, Lian et al.

Source: Marine Drugs. May2026, Vol. 24 Issue 5, p177. 15p.

Convergent Total Synthesis of PM742 and SAR-Guided Development of the Clinical Candidate PM534.

Authors: Martín, María Jesús Hernando, Juan Rodríguez-Acebes, Raquel et al.

Source: Marine Drugs. May2026, Vol. 24 Issue 5, p167. 11p.

A Study of 3-Substituted 7-Methoxy-2,3,4,5-tetrahydro-1 H -benzo[ d ]azepin-1-ols Leading to Candidate PET Radioligands for Imaging Brain GluN2B: Design, Synthesis, and Structure–Activity Relationships.

Authors: Cai, Lisheng Millard, Leah Noelle Costner, Sean Wallace et al.

Source: Molecules. May2026, Vol. 31 Issue 9, p1541. 30p.

PARP-1 inhibitors in cancer therapy: design, molecular modeling, structure–activity relationships, and clinical advances.

Authors: Abdullah, Rosine Ewida, Menna A. Fawzy, Iten M. et al.

Source: Future Journal of Pharmaceutical Sciences. 5/1/2026, Vol. 12 Issue 1, p1-31. 31p.

Structure–Acidity–Activity Correlation in Ammonia Decomposition over Al-Based Mixed-Oxide Catalysts: A Combined Surface and Kinetic Study.

Authors: Litinschi, Mihaela Doukeh, Rami Győrgy, Romuald et al.

Source: Catalysts (2073-4344). May2026, Vol. 16 Issue 5, p405. 28p.

Structure–Activity Relationships of Hemocompatible Cationic 6-Azaindole Pyridinium Salts: Antimicrobial and Anticancer Activity.

Authors: Ciorteanu, Roxana Marinas, Ioana C. Ciobanu, Catalina Ionica et al.

Source: Molecules. Apr2026, Vol. 31 Issue 7, p1220. 18p.

Novel Small Molecule GLP-1R Agonists Based on 1 H -Benzo[ d ]imidazole-5-Carboxylic Acid Scaffold.

Authors: Tolkacheva, Elena V. Salakhov, Tagir L. Saliev, Alexandr Yu. et al.

Source: Molecules. Apr2026, Vol. 31 Issue 7, p1129. 18p.

Structure-Guided Identification of Phytochemical OCT2 Inhibitors and Their Functional Relevance to Cisplatin-Induced Cytotoxicity.

Authors: Song, Hyerim Lee, Kyeong-Ryoon Li, Hui et al.

Source: Pharmaceutics. Apr2026, Vol. 18 Issue 4, p486. 17p.

AI‐Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR‐Tractable RNA Binders and Rational Analog Design.

Authors: Hattori, Haruhiko Otsu, Maina Imai, Koji et al.

Source: Small Science. Apr2026, Vol. 6 Issue 4, p1-14. 14p.

Structure–Activity Relationships, Molecular Mechanisms, and Ecotoxicological Evaluation Underlying Nucleoside-Mediated Antifouling Activity.

Authors: Pereira, Sandra Oliveira, Isabel B. Palmeira, Andreia et al.

Source: Biomolecules (2218-273X). Apr2026, Vol. 16 Issue 4, p584. 28p.