A Probabilistic Approach to Evaluate the Risk of Decreased Total Triiodothyronine Hormone Levels following Chronic Exposure to PFOS and PFHxS via Contaminated Drinking Water.
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| Title: | A Probabilistic Approach to Evaluate the Risk of Decreased Total Triiodothyronine Hormone Levels following Chronic Exposure to PFOS and PFHxS via Contaminated Drinking Water. |
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| Authors: | Silva, Antero Vieira1 antero.silva@ki.se, Ringblom, Joakim1, Lindh, Christian2, Scott, Kristin2, Jakobsson, Kristina2,3, Öberg, Mattias1 |
| Source: | Environmental Health Perspectives. Jul2020, Vol. 128 Issue 7, p076001-1-076001-11. 11p. 1 Diagram, 5 Charts, 5 Graphs. |
| Subject Terms: | *Animal experimentation, *Dose-response relationship in biochemistry, *Fluorocarbons, *Water pollution, *Water supply, Benchmarking (Management), Confidence intervals, Primates, Probability theory, Research funding, Risk assessment, Triiodothyronine, Sulfur acids, Data analysis software, Descriptive statistics |
| Geographic Terms: | Sweden |
| Abstract: | BACKGROUND: Extensive exposure to per- and polyfluoroalkyl substances (PFAS) have been observed in many countries. Current deterministic frameworks for risk assessment lack the ability to predict the likelihood of effects and to assess uncertainty. When exposure exceeds tolerable intake levels, these shortcomings hamper risk management and communication. OBJECTIVE: The integrated probabilistic risk assessment (IPRA) combines dose-response and exposure data to estimate the likelihood of adverse effects. We evaluated the usefulness of the IPRA for risk characterization related to decreased levels of total triiodothyronine (T3) in humans following a real case of high exposure to PFAS via drinking water. METHODS: PFAS exposure was defined as serum levels from residents of a contaminated area in Ronneby, Sweden. Median levels were 270 ng/mL [perfluorooctane sulfonic acid (PFOS)] and 229 ng/mL [perfluorohexane sulfonic acid (PFHxS)] for individuals who resided in Ronneby 1 y before the exposure termination. This data was integrated with data from a subchronic toxicity study in monkeys exposed daily to PFOS. Benchmark dose modeling was employed to describe separate dose-effect relationship for males and females, and extrapolation factor distributions were used to estimate the corresponding human benchmark dose. The critical effect level was defined as a 10% decrease in total T3. RESULTS: The median probability of critical exposure, following a combined exposure to PFOS and PFHxS, was estimated to be [2.1% (90% CI: 0:4%-13:1%)]. Gender-based analysis showed that this risk was almost entirely distributed among women, namely [3.9% (90% CI: 0:8%-21:6%)]. DISCUSSION: The IPRA was compared with the traditional deterministic Margin of Exposure (MoE) approach. We conclude that probabilistic risk characterization represents an important step forward in the ability to adequately analyze group-specific health risks. Moreover, quantifying the sources of uncertainty is desirable, as it improves the awareness among stakeholders and will guide future efforts to improve accuracy. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 145196644 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Probabilistic Approach to Evaluate the Risk of Decreased Total Triiodothyronine Hormone Levels following Chronic Exposure to PFOS and PFHxS via Contaminated Drinking Water. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Silva%2C+Antero+Vieira%22">Silva, Antero Vieira</searchLink><relatesTo>1</relatesTo><i> antero.silva@ki.se</i><br /><searchLink fieldCode="AR" term="%22Ringblom%2C+Joakim%22">Ringblom, Joakim</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lindh%2C+Christian%22">Lindh, Christian</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Scott%2C+Kristin%22">Scott, Kristin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jakobsson%2C+Kristina%22">Jakobsson, Kristina</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Öberg%2C+Mattias%22">Öberg, Mattias</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jul2020, Vol. 128 Issue 7, p076001-1-076001-11. 11p. 1 Diagram, 5 Charts, 5 Graphs. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br />*<searchLink fieldCode="DE" term="%22Dose-response+relationship+in+biochemistry%22">Dose-response relationship in biochemistry</searchLink><br />*<searchLink fieldCode="DE" term="%22Fluorocarbons%22">Fluorocarbons</searchLink><br />*<searchLink fieldCode="DE" term="%22Water+pollution%22">Water pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Water+supply%22">Water supply</searchLink><br /><searchLink fieldCode="DE" term="%22Benchmarking+%28Management%29%22">Benchmarking (Management)</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Primates%22">Primates</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Triiodothyronine%22">Triiodothyronine</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfur+acids%22">Sulfur acids</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Extensive exposure to per- and polyfluoroalkyl substances (PFAS) have been observed in many countries. Current deterministic frameworks for risk assessment lack the ability to predict the likelihood of effects and to assess uncertainty. When exposure exceeds tolerable intake levels, these shortcomings hamper risk management and communication. OBJECTIVE: The integrated probabilistic risk assessment (IPRA) combines dose-response and exposure data to estimate the likelihood of adverse effects. We evaluated the usefulness of the IPRA for risk characterization related to decreased levels of total triiodothyronine (T3) in humans following a real case of high exposure to PFAS via drinking water. METHODS: PFAS exposure was defined as serum levels from residents of a contaminated area in Ronneby, Sweden. Median levels were 270 ng/mL [perfluorooctane sulfonic acid (PFOS)] and 229 ng/mL [perfluorohexane sulfonic acid (PFHxS)] for individuals who resided in Ronneby 1 y before the exposure termination. This data was integrated with data from a subchronic toxicity study in monkeys exposed daily to PFOS. Benchmark dose modeling was employed to describe separate dose-effect relationship for males and females, and extrapolation factor distributions were used to estimate the corresponding human benchmark dose. The critical effect level was defined as a 10% decrease in total T3. RESULTS: The median probability of critical exposure, following a combined exposure to PFOS and PFHxS, was estimated to be [2.1% (90% CI: 0:4%-13:1%)]. Gender-based analysis showed that this risk was almost entirely distributed among women, namely [3.9% (90% CI: 0:8%-21:6%)]. DISCUSSION: The IPRA was compared with the traditional deterministic Margin of Exposure (MoE) approach. We conclude that probabilistic risk characterization represents an important step forward in the ability to adequately analyze group-specific health risks. Moreover, quantifying the sources of uncertainty is desirable, as it improves the awareness among stakeholders and will guide future efforts to improve accuracy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/EHP6654 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 076001-1 Subjects: – SubjectFull: Animal experimentation Type: general – SubjectFull: Dose-response relationship in biochemistry Type: general – SubjectFull: Fluorocarbons Type: general – SubjectFull: Water pollution Type: general – SubjectFull: Water supply Type: general – SubjectFull: Benchmarking (Management) Type: general – SubjectFull: Confidence intervals Type: general – SubjectFull: Primates Type: general – SubjectFull: Probability theory Type: general – SubjectFull: Research funding Type: general – SubjectFull: Risk assessment Type: general – SubjectFull: Triiodothyronine Type: general – SubjectFull: Sulfur acids Type: general – SubjectFull: Data analysis software Type: general – SubjectFull: Descriptive statistics Type: general – SubjectFull: Sweden Type: general Titles: – TitleFull: A Probabilistic Approach to Evaluate the Risk of Decreased Total Triiodothyronine Hormone Levels following Chronic Exposure to PFOS and PFHxS via Contaminated Drinking Water. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Silva, Antero Vieira – PersonEntity: Name: NameFull: Ringblom, Joakim – PersonEntity: Name: NameFull: Lindh, Christian – PersonEntity: Name: NameFull: Scott, Kristin – PersonEntity: Name: NameFull: Jakobsson, Kristina – PersonEntity: Name: NameFull: Öberg, Mattias IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 128 – Type: issue Value: 7 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
