Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.
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| Title: | Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature. |
|---|---|
| Authors: | Weuve, Jennifer1, Bennett, Erin E.2, Ranker, Lynsie1, Gianattasio, Kan Z.2, Pedde, Meredith3, Adar, Sara D.3, Yanosky, Jeff D.4, Power, MelindaC.2 power@gwu.edu |
| Source: | Environmental Health Perspectives. Sep2021, Vol. 129 Issue 9, p1-096001-24. 24p. 4 Charts. |
| Subject Terms: | *Air pollution, *Environmental exposure, Dementia risk factors |
| Abstract: | BACKGROUND: Dementia is a devastating neurologic condition that is common in older adults. We previously reviewed the epidemiological evidence examining the hypothesis that long-term exposure to air pollution affects dementia risk. Since then, the evidence base has expanded rapidly. OBJECTIVES: With this update, we collectively review new and previously identified epidemiological studies on air pollution and late-life cognitive health, highlighting new developments and critically discussing the merits of the evidence. METHODS: Using a registered protocol (PROSPERO 2020 CRD42020152943), we updated our literature review to capture studies published through 31 December 2020, extracted data, and conducted a bias assessment. RESULTS: We identified 66 papers (49 new) for inclusion in this review. Cognitive level remained the most commonly considered outcome, and particulate matter (PM) remained the most commonly considered air pollutant. Since our prior review, exposure estimation methods in this research have improved, and more papers have looked at cognitive change, neuroimaging, and incident cognitive impairment/dementia, though methodological concerns remain common. Many studies continue to rely on administrative records to ascertain dementia, have high potential for selection bias, and adjust for putative mediating factors in primary models. A subset of 35 studies met strict quality criteria. Although high-quality studies of fine particulate matter with aerodynamic diameter =2.5 µm (PM2.5) and cognitive decline generally supported an adverse association, other findings related to PM2.5 and findings related to particulate matter with aerodynamic diameter =10 µm (PM10, NO2, and NOx) were inconclusive, and too few papers reported findings with ozone to comment on the likely direction of association. Notably, only a few findings on dementia were included for consideration on the basis of quality criteria. DISCUSSION: Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between PM2.5 and cognitive decline. However, we note a continued need to confront methodological challenges in this line of research. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 153020750 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Weuve%2C+Jennifer%22">Weuve, Jennifer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bennett%2C+Erin+E%2E%22">Bennett, Erin E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ranker%2C+Lynsie%22">Ranker, Lynsie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gianattasio%2C+Kan+Z%2E%22">Gianattasio, Kan Z.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pedde%2C+Meredith%22">Pedde, Meredith</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Adar%2C+Sara+D%2E%22">Adar, Sara D.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yanosky%2C+Jeff+D%2E%22">Yanosky, Jeff D.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Power%2C+MelindaC%2E%22">Power, MelindaC.</searchLink><relatesTo>2</relatesTo><i> power@gwu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Sep2021, Vol. 129 Issue 9, p1-096001-24. 24p. 4 Charts. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Dementia+risk+factors%22">Dementia risk factors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Dementia is a devastating neurologic condition that is common in older adults. We previously reviewed the epidemiological evidence examining the hypothesis that long-term exposure to air pollution affects dementia risk. Since then, the evidence base has expanded rapidly. OBJECTIVES: With this update, we collectively review new and previously identified epidemiological studies on air pollution and late-life cognitive health, highlighting new developments and critically discussing the merits of the evidence. METHODS: Using a registered protocol (PROSPERO 2020 CRD42020152943), we updated our literature review to capture studies published through 31 December 2020, extracted data, and conducted a bias assessment. RESULTS: We identified 66 papers (49 new) for inclusion in this review. Cognitive level remained the most commonly considered outcome, and particulate matter (PM) remained the most commonly considered air pollutant. Since our prior review, exposure estimation methods in this research have improved, and more papers have looked at cognitive change, neuroimaging, and incident cognitive impairment/dementia, though methodological concerns remain common. Many studies continue to rely on administrative records to ascertain dementia, have high potential for selection bias, and adjust for putative mediating factors in primary models. A subset of 35 studies met strict quality criteria. Although high-quality studies of fine particulate matter with aerodynamic diameter =2.5 µm (PM2.5) and cognitive decline generally supported an adverse association, other findings related to PM2.5 and findings related to particulate matter with aerodynamic diameter =10 µm (PM10, NO2, and NOx) were inconclusive, and too few papers reported findings with ozone to comment on the likely direction of association. Notably, only a few findings on dementia were included for consideration on the basis of quality criteria. DISCUSSION: Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between PM2.5 and cognitive decline. However, we note a continued need to confront methodological challenges in this line of research. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/EHP8716 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 1 Subjects: – SubjectFull: Air pollution Type: general – SubjectFull: Environmental exposure Type: general – SubjectFull: Dementia risk factors Type: general Titles: – TitleFull: Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Weuve, Jennifer – PersonEntity: Name: NameFull: Bennett, Erin E. – PersonEntity: Name: NameFull: Ranker, Lynsie – PersonEntity: Name: NameFull: Gianattasio, Kan Z. – PersonEntity: Name: NameFull: Pedde, Meredith – PersonEntity: Name: NameFull: Adar, Sara D. – PersonEntity: Name: NameFull: Yanosky, Jeff D. – PersonEntity: Name: NameFull: Power, MelindaC. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 129 – Type: issue Value: 9 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
