Metals in Urine and Peripheral Arterial Disease.
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| Title: | Metals in Urine and Peripheral Arterial Disease. |
|---|---|
| Authors: | Navas-Acien, Ana1,2,3, Silbergeld, Ellen K.4, Sharrett, A. Richey1, Calderon-Aranda, Emma4,5, Selvin, Elizabeth1,2, Guallar, Eliseo1,2,3 eguallar@jhsph.edu |
| Source: | Environmental Health Perspectives. Feb2005, Vol. 113 Issue 2, p164-169. 6p. |
| Subject Terms: | *Metals, *Pollutants, *Environmental health, Urine, Atherosclerosis, Arterial diseases |
| Abstract: | Exposure to metals may promote atherosclerosis. Blood cadmium and lead were associated with peripheral arterial disease (PAD) in the 1999-2000 National Health and Nutrition Examination Survey (NHANES), In the present study we evaluated the association between urinary levels of cadmium, lead, barium, cobalt, cesium, molybdenum, antimony, thallium, and tungsten with PAD in a cross-sectional analysis of 790 participants 40 years of age in NHANES 1999-2000. PAD was defined as a blood pressure anide brachial index c 0.9 in at least one leg. Metals were measured in casual (spot) urine specimens by inductively coupled plasma-mass spectrometry. After multi- variable adjustment, subjects with PAD had 36% higher levels of cadmium in urine and 49% higher levels of tungsten compared with noncases. The adjusted odds ratio for PAD comparing the 75th to the 25th percentile of the cadmium distribution was 3.05 [95% confidence interval (CI), 0.97 to 9.5811; that for tungsten was 2.25 (95% CI, 0.97 to 5.24). PAD risk increased sharply at low levels of antimony and remained elevated beyond 0.1 μg/L. PAD was not associated with other metals. In conclusion, urinary cadmium, tungsten, and possibly antimony were associated with PAD in a representative sample of the U.S. population. For cadmium, these results strengthen previous findings using blood cadmium as a biomarker, and they support its role in atherosclerosis. For tungsten and antimony, these results need to be interpreted cautiously in the context of an exploratory analysis but deserve further study. Other metals in urine were not associated with PAD at the levels found in the general population. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 16467199 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Metals in Urine and Peripheral Arterial Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Navas-Acien%2C+Ana%22">Navas-Acien, Ana</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Silbergeld%2C+Ellen+K%2E%22">Silbergeld, Ellen K.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sharrett%2C+A%2E+Richey%22">Sharrett, A. Richey</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Calderon-Aranda%2C+Emma%22">Calderon-Aranda, Emma</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Selvin%2C+Elizabeth%22">Selvin, Elizabeth</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Guallar%2C+Eliseo%22">Guallar, Eliseo</searchLink><relatesTo>1,2,3</relatesTo><i> eguallar@jhsph.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Feb2005, Vol. 113 Issue 2, p164-169. 6p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Metals%22">Metals</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+health%22">Environmental health</searchLink><br /><searchLink fieldCode="DE" term="%22Urine%22">Urine</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerosis%22">Atherosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+diseases%22">Arterial diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Exposure to metals may promote atherosclerosis. Blood cadmium and lead were associated with peripheral arterial disease (PAD) in the 1999-2000 National Health and Nutrition Examination Survey (NHANES), In the present study we evaluated the association between urinary levels of cadmium, lead, barium, cobalt, cesium, molybdenum, antimony, thallium, and tungsten with PAD in a cross-sectional analysis of 790 participants 40 years of age in NHANES 1999-2000. PAD was defined as a blood pressure anide brachial index c 0.9 in at least one leg. Metals were measured in casual (spot) urine specimens by inductively coupled plasma-mass spectrometry. After multi- variable adjustment, subjects with PAD had 36% higher levels of cadmium in urine and 49% higher levels of tungsten compared with noncases. The adjusted odds ratio for PAD comparing the 75th to the 25th percentile of the cadmium distribution was 3.05 [95% confidence interval (CI), 0.97 to 9.5811; that for tungsten was 2.25 (95% CI, 0.97 to 5.24). PAD risk increased sharply at low levels of antimony and remained elevated beyond 0.1 μg/L. PAD was not associated with other metals. In conclusion, urinary cadmium, tungsten, and possibly antimony were associated with PAD in a representative sample of the U.S. population. For cadmium, these results strengthen previous findings using blood cadmium as a biomarker, and they support its role in atherosclerosis. For tungsten and antimony, these results need to be interpreted cautiously in the context of an exploratory analysis but deserve further study. Other metals in urine were not associated with PAD at the levels found in the general population. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.7329 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 164 Subjects: – SubjectFull: Metals Type: general – SubjectFull: Pollutants Type: general – SubjectFull: Environmental health Type: general – SubjectFull: Urine Type: general – SubjectFull: Atherosclerosis Type: general – SubjectFull: Arterial diseases Type: general Titles: – TitleFull: Metals in Urine and Peripheral Arterial Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Navas-Acien, Ana – PersonEntity: Name: NameFull: Silbergeld, Ellen K. – PersonEntity: Name: NameFull: Sharrett, A. Richey – PersonEntity: Name: NameFull: Calderon-Aranda, Emma – PersonEntity: Name: NameFull: Selvin, Elizabeth – PersonEntity: Name: NameFull: Guallar, Eliseo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 113 – Type: issue Value: 2 Titles: – TitleFull: Environmental Health Perspectives Type: main |
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