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The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.

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Title: The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.
Authors: Paciência, Inês1,2, Sharma, Needhi3, Hugg, Timo T.1,2, Rantala, Aino K.1,2, Heibati, Behzad1,2, Al-Delaimy, Wael K.3, Jaakkola, Maritta S.1,2, Jaakkola, Jouni J. K.1,2,4 jouni.jaakkola@oulu.fi
Source: Environmental Health Perspectives. Jun2024, Vol. 132 Issue 6, p066001-1-066001-21. 21p.
Subject Terms: *Environmental health, *Allergies, *Ecosystems, *Environmental exposure, *Microbial ecology, Respiratory organ microbiology, Asthma risk factors, Skin microbiology, Respiratory organ sounds, Risk assessment, Research funding, Gut microbiota, Microbiota, Systematic reviews, MEDLINE, Online information services, Disease risk factors
Abstract: BACKGROUND: Changes in land use and climate change have been reported to reduce biodiversity of both the environment and human microbiota. These reductions in biodiversity may lead to inadequate and unbalanced stimulation of immunoregulatory circuits and, ultimately, to clinical diseases, such as asthma and allergies. OBJECTIVE: We summarized available empirical evidence on the role of inner (gut, skin, and airways) and outer (air, soil, natural waters, plants, and animals) layers of biodiversity in the development of asthma, wheezing, and allergic sensitization. METHODS: We conducted a systematic search in SciVerse Scopus, PubMed MEDLINE, and Web of Science up to 5 March 2024 to identify relevant human studies assessing the relationships between inner and outer layers of biodiversity and the risk of asthma, wheezing, or allergic sensitization. The protocol was registered in PROSPERO (CRD42022381725). RESULTS: A total of 2,419 studies were screened and, after exclusions and a full-text review of 447 studies, 82 studies were included in the comprehensive, final review. Twenty-nine studies reported a protective effect of outer layer biodiversity in the development of asthma, wheezing, or allergic sensitization. There were also 16 studies suggesting an effect of outer layer biodiversity on increasing asthma, wheezing, or allergic sensitization. However, there was no clear evidence on the role of inner layer biodiversity in the development of asthma, wheezing, and allergic sensitization (13 studies reported a protective effect and 15 reported evidence of an increased risk). CONCLUSIONS: Based on the reviewed literature, a future systematic review could focus more specifically on outer layer biodiversity and asthma. It is unlikely that association with inner layer biodiversity would have enough evidence for systematic review. Based on this comprehensive review, there is a need for population-based longitudinal studies to identify critical periods of exposure in the life course into adulthood and to better understand mechanisms linking environmental exposures and changes in microbiome composition, diversity, and/or function to development of asthma and allergic sensitization. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.
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  Data: <searchLink fieldCode="AR" term="%22Paciência%2C+Inês%22">Paciência, Inês</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sharma%2C+Needhi%22">Sharma, Needhi</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hugg%2C+Timo+T%2E%22">Hugg, Timo T.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rantala%2C+Aino+K%2E%22">Rantala, Aino K.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Heibati%2C+Behzad%22">Heibati, Behzad</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Al-Delaimy%2C+Wael+K%2E%22">Al-Delaimy, Wael K.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jaakkola%2C+Maritta+S%2E%22">Jaakkola, Maritta S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jaakkola%2C+Jouni+J%2E+K%2E%22">Jaakkola, Jouni J. K.</searchLink><relatesTo>1,2,4</relatesTo><i> jouni.jaakkola@oulu.fi</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jun2024, Vol. 132 Issue 6, p066001-1-066001-21. 21p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Changes in land use and climate change have been reported to reduce biodiversity of both the environment and human microbiota. These reductions in biodiversity may lead to inadequate and unbalanced stimulation of immunoregulatory circuits and, ultimately, to clinical diseases, such as asthma and allergies. OBJECTIVE: We summarized available empirical evidence on the role of inner (gut, skin, and airways) and outer (air, soil, natural waters, plants, and animals) layers of biodiversity in the development of asthma, wheezing, and allergic sensitization. METHODS: We conducted a systematic search in SciVerse Scopus, PubMed MEDLINE, and Web of Science up to 5 March 2024 to identify relevant human studies assessing the relationships between inner and outer layers of biodiversity and the risk of asthma, wheezing, or allergic sensitization. The protocol was registered in PROSPERO (CRD42022381725). RESULTS: A total of 2,419 studies were screened and, after exclusions and a full-text review of 447 studies, 82 studies were included in the comprehensive, final review. Twenty-nine studies reported a protective effect of outer layer biodiversity in the development of asthma, wheezing, or allergic sensitization. There were also 16 studies suggesting an effect of outer layer biodiversity on increasing asthma, wheezing, or allergic sensitization. However, there was no clear evidence on the role of inner layer biodiversity in the development of asthma, wheezing, and allergic sensitization (13 studies reported a protective effect and 15 reported evidence of an increased risk). CONCLUSIONS: Based on the reviewed literature, a future systematic review could focus more specifically on outer layer biodiversity and asthma. It is unlikely that association with inner layer biodiversity would have enough evidence for systematic review. Based on this comprehensive review, there is a need for population-based longitudinal studies to identify critical periods of exposure in the life course into adulthood and to better understand mechanisms linking environmental exposures and changes in microbiome composition, diversity, and/or function to development of asthma and allergic sensitization. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1289/EHP13948
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        Text: English
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      – SubjectFull: Environmental health
        Type: general
      – SubjectFull: Allergies
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      – SubjectFull: Ecosystems
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      – SubjectFull: Environmental exposure
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      – SubjectFull: Microbial ecology
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      – SubjectFull: Asthma risk factors
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      – SubjectFull: Research funding
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              Text: Jun2024
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