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Maternal Exposure to Per- and Polyfluoroalkyl Substances and Offspring Chromosomal Abnormalities: The Japan Environment and Children's Study.

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Title: Maternal Exposure to Per- and Polyfluoroalkyl Substances and Offspring Chromosomal Abnormalities: The Japan Environment and Children's Study.
Authors: Kohei Hasegawa1,2 koheih@shinshu-u.ac.jp, Noriko Motoki1,2, Yuji Inaba2,3,4, Hirokazu Toubou1,2, Takumi Shibazaki5, Nakayama, Shoji F.6, Michihiro Kamijima7, Teruomi Tsukahara1,2,8, Tetsuo Nomiyama1,2,8, the Japan Environment and Children's Study Group
Source: Environmental Health Perspectives. Sep2024, Vol. 132 Issue 9, p097004-1-097004-10. 10p.
Subject Terms: *Pollutants, *Fluorocarbons, Prenatal exposure delayed effects, Maternal exposure, Liquid chromatography-mass spectrometry, Data analysis, Maternal age, Computer software, Logistic regression analysis, Questionnaires, Probability theory, Chromosome abnormalities, Treatment effectiveness, Odds ratio, Statistics, Medical records, Parity (Obstetrics), First trimester of pregnancy, Sulfur acids, Confidence intervals, Data analysis software, Childbirth, Sensitivity & specificity (Statistics)
Abstract: BACKGROUND: Although recent in vitro experimental results have raised the question of whether maternal exposure to per- and polyfluoroalkyl substances (PFAS) may be a potential environmental risk factor for chromosomal abnormalities, epidemiological studies investigating these associations are lacking. OBJECTIVES: This study examined whether prenatal PFAS exposure is associated with a higher prevalence of chromosomal abnormalities among offspring. METHODS: We used data from the Japan Environment and Children’s Study, a nationwide birth cohort study, and employed logistic regression models to examine the associations between maternal plasma PFAS concentrations in the first trimester and the diagnosis of chromosomal abnormalities in all births (artificial abortions, miscarriages, stillbirths, and live births) up to 2 years of age. In addition, we examined associations with mixtures of PFAS using multipollutant models. RESULTS: The final sample consisted of 24,724 births with singleton pregnancies, of which 44 confirmed cases of chromosomal abnormalities were identified (prevalence: 17.8/10,000 births). When examined individually, exposure to perfluorononanoic acid (PFNA) and perfluorooctane sulfonic acid (PFOS) showed positive associations with any chromosomal abnormalities with age-adjusted odds ratios of 1.81 (95% CI: 1.26, 2.61) and 2.08 (95% CI: 1.41, 3.07) per doubling in concentration, respectively. These associations remained significant after Bonferroni correction, although they did not reach the adjusted significance threshold in certain sensitivity analyses. Furthermore, the doubling in all PFAS included as a mixture was associated with chromosomal abnormalities, indicating an age-adjusted odds ratio of 2.25 (95% CI: 1.34, 3.80), with PFOS as the predominant contributor, followed by PFNA, perfluoroundecanoic acid (PFUnA), and perfluorooctanoic acid (PFOA). DISCUSSION: The study findings suggested a potential association between maternal exposure to PFAS, particularly PFOS, and chromosomal abnormalities in offspring. However, the results should be interpreted cautiously, because selection bias arising from the recruitment of women in early pregnancy may explain the associations. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Maternal Exposure to Per- and Polyfluoroalkyl Substances and Offspring Chromosomal Abnormalities: The Japan Environment and Children's Study.
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  Data: <searchLink fieldCode="AR" term="%22Kohei+Hasegawa%22">Kohei Hasegawa</searchLink><relatesTo>1,2</relatesTo><i> koheih@shinshu-u.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Noriko+Motoki%22">Noriko Motoki</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yuji+Inaba%22">Yuji Inaba</searchLink><relatesTo>2,3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Hirokazu+Toubou%22">Hirokazu Toubou</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Takumi+Shibazaki%22">Takumi Shibazaki</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Nakayama%2C+Shoji+F%2E%22">Nakayama, Shoji F.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Michihiro+Kamijima%22">Michihiro Kamijima</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Teruomi+Tsukahara%22">Teruomi Tsukahara</searchLink><relatesTo>1,2,8</relatesTo><br /><searchLink fieldCode="AR" term="%22Tetsuo+Nomiyama%22">Tetsuo Nomiyama</searchLink><relatesTo>1,2,8</relatesTo><br /><searchLink fieldCode="AR" term="%22the+Japan+Environment+and+Children's+Study+Group%22">the Japan Environment and Children's Study Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Sep2024, Vol. 132 Issue 9, p097004-1-097004-10. 10p.
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  Data: *<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Fluorocarbons%22">Fluorocarbons</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+exposure+delayed+effects%22">Prenatal exposure delayed effects</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal+exposure%22">Maternal exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal+age%22">Maternal age</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+software%22">Computer software</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosome+abnormalities%22">Chromosome abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Parity+%28Obstetrics%29%22">Parity (Obstetrics)</searchLink><br /><searchLink fieldCode="DE" term="%22First+trimester+of+pregnancy%22">First trimester of pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfur+acids%22">Sulfur acids</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Childbirth%22">Childbirth</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Although recent in vitro experimental results have raised the question of whether maternal exposure to per- and polyfluoroalkyl substances (PFAS) may be a potential environmental risk factor for chromosomal abnormalities, epidemiological studies investigating these associations are lacking. OBJECTIVES: This study examined whether prenatal PFAS exposure is associated with a higher prevalence of chromosomal abnormalities among offspring. METHODS: We used data from the Japan Environment and Children’s Study, a nationwide birth cohort study, and employed logistic regression models to examine the associations between maternal plasma PFAS concentrations in the first trimester and the diagnosis of chromosomal abnormalities in all births (artificial abortions, miscarriages, stillbirths, and live births) up to 2 years of age. In addition, we examined associations with mixtures of PFAS using multipollutant models. RESULTS: The final sample consisted of 24,724 births with singleton pregnancies, of which 44 confirmed cases of chromosomal abnormalities were identified (prevalence: 17.8/10,000 births). When examined individually, exposure to perfluorononanoic acid (PFNA) and perfluorooctane sulfonic acid (PFOS) showed positive associations with any chromosomal abnormalities with age-adjusted odds ratios of 1.81 (95% CI: 1.26, 2.61) and 2.08 (95% CI: 1.41, 3.07) per doubling in concentration, respectively. These associations remained significant after Bonferroni correction, although they did not reach the adjusted significance threshold in certain sensitivity analyses. Furthermore, the doubling in all PFAS included as a mixture was associated with chromosomal abnormalities, indicating an age-adjusted odds ratio of 2.25 (95% CI: 1.34, 3.80), with PFOS as the predominant contributor, followed by PFNA, perfluoroundecanoic acid (PFUnA), and perfluorooctanoic acid (PFOA). DISCUSSION: The study findings suggested a potential association between maternal exposure to PFAS, particularly PFOS, and chromosomal abnormalities in offspring. However, the results should be interpreted cautiously, because selection bias arising from the recruitment of women in early pregnancy may explain the associations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1289/EHP13617
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 097004-1
    Subjects:
      – SubjectFull: Pollutants
        Type: general
      – SubjectFull: Fluorocarbons
        Type: general
      – SubjectFull: Prenatal exposure delayed effects
        Type: general
      – SubjectFull: Maternal exposure
        Type: general
      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Maternal age
        Type: general
      – SubjectFull: Computer software
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Probability theory
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      – SubjectFull: Chromosome abnormalities
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Odds ratio
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      – SubjectFull: Statistics
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      – SubjectFull: Medical records
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      – SubjectFull: Parity (Obstetrics)
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      – SubjectFull: First trimester of pregnancy
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      – SubjectFull: Sulfur acids
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Data analysis software
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      – SubjectFull: Childbirth
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      – SubjectFull: Sensitivity & specificity (Statistics)
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              Text: Sep2024
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