Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada.
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| Title: | Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada. |
|---|---|
| Authors: | Steinberg, Karen K.1 kks1@cdc.gov, Relling, Mary V.2, Gallagher, Margaret L.1, Greene, Christopher N.1, Rubin, Carol S.3, French, Deborah2, Holmes, Adrianne K.3, Carroll, William L.4, Koontz, Deborah A.1, Sampson, Eric J.1, Satten, Glen A.1 |
| Source: | Environmental Health Perspectives. Jan2007, Vol. 115 Issue 1, p158-164. 7p. |
| Subject Terms: | *Arsenic poisoning, *Pollution, *Environmental health research, Leukemia in children, Tungsten, Genetic disorders, Genes, Bioactive compounds, Xanthine, Cancer risk factors, Disease risk factors |
| Geographic Terms: | United States |
| Abstract: | OBJECTIVE: In a study to identify exposures associated with 15 cases of childhood leukemia, we found levels of tungsten, arsenic, and dichlorodiphenyldichloroethylene in participants to be higher than mean values reported in the National Report on Human Exposure to Environmental Chemicals. Because case and comparison families had similar levels of these contaminants, we conducted genetic studies to identify gene polymorphisms that might have made case children more susceptible than comparison children to effects of the exposures. DESIGN: We compared case with comparison children to determine whether differences existed in the frequency of polymorphic genes, including genes that code for enzymes in the folate and purine pathways. We also included discovery of polymorphic forms of genes that code for enzymes that are inhibited by tungsten: xanthine dehydrogenase, sulfite oxidase (SUOX gene), and aldehyde oxidase. PARTICIPANTS: Eleven case children were age- and sex-matched with 42 community comparison children for genetic analyses. Twenty parents of case children also contributed to the analyses. RESULTS: One bilalleleic gene locus in SUOX was significantly associated with either case or comparison status, depending on which alleles the child carried (without adjusting for multiple comparisons). CONCLUSIONS: Although genetic studies did not provide evidence that a common agent or genetic susceptibility factor caused the leukemias, the association between a SUOX gene locus and disease status in the presence of high tungsten and arsenic levels warrants further investigation. RELEVANCE: Although analyses of community clusters of cancer have rarely identified causes, these findings have generated hypotheses to be tested in subsequent studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 24222511 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Steinberg%2C+Karen+K%2E%22">Steinberg, Karen K.</searchLink><relatesTo>1</relatesTo><i> kks1@cdc.gov</i><br /><searchLink fieldCode="AR" term="%22Relling%2C+Mary+V%2E%22">Relling, Mary V.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gallagher%2C+Margaret+L%2E%22">Gallagher, Margaret L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Greene%2C+Christopher+N%2E%22">Greene, Christopher N.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rubin%2C+Carol+S%2E%22">Rubin, Carol S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22French%2C+Deborah%22">French, Deborah</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Holmes%2C+Adrianne+K%2E%22">Holmes, Adrianne K.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Carroll%2C+William+L%2E%22">Carroll, William L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Koontz%2C+Deborah+A%2E%22">Koontz, Deborah A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sampson%2C+Eric+J%2E%22">Sampson, Eric J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Satten%2C+Glen+A%2E%22">Satten, Glen A.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jan2007, Vol. 115 Issue 1, p158-164. 7p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Arsenic+poisoning%22">Arsenic poisoning</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollution%22">Pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+health+research%22">Environmental health research</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia+in+children%22">Leukemia in children</searchLink><br /><searchLink fieldCode="DE" term="%22Tungsten%22">Tungsten</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+compounds%22">Bioactive compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Xanthine%22">Xanthine</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+risk+factors%22">Cancer risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: In a study to identify exposures associated with 15 cases of childhood leukemia, we found levels of tungsten, arsenic, and dichlorodiphenyldichloroethylene in participants to be higher than mean values reported in the National Report on Human Exposure to Environmental Chemicals. Because case and comparison families had similar levels of these contaminants, we conducted genetic studies to identify gene polymorphisms that might have made case children more susceptible than comparison children to effects of the exposures. DESIGN: We compared case with comparison children to determine whether differences existed in the frequency of polymorphic genes, including genes that code for enzymes in the folate and purine pathways. We also included discovery of polymorphic forms of genes that code for enzymes that are inhibited by tungsten: xanthine dehydrogenase, sulfite oxidase (SUOX gene), and aldehyde oxidase. PARTICIPANTS: Eleven case children were age- and sex-matched with 42 community comparison children for genetic analyses. Twenty parents of case children also contributed to the analyses. RESULTS: One bilalleleic gene locus in SUOX was significantly associated with either case or comparison status, depending on which alleles the child carried (without adjusting for multiple comparisons). CONCLUSIONS: Although genetic studies did not provide evidence that a common agent or genetic susceptibility factor caused the leukemias, the association between a SUOX gene locus and disease status in the presence of high tungsten and arsenic levels warrants further investigation. RELEVANCE: Although analyses of community clusters of cancer have rarely identified causes, these findings have generated hypotheses to be tested in subsequent studies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.9025 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 158 Subjects: – SubjectFull: Arsenic poisoning Type: general – SubjectFull: Pollution Type: general – SubjectFull: Environmental health research Type: general – SubjectFull: Leukemia in children Type: general – SubjectFull: Tungsten Type: general – SubjectFull: Genetic disorders Type: general – SubjectFull: Genes Type: general – SubjectFull: Bioactive compounds Type: general – SubjectFull: Xanthine Type: general – SubjectFull: Cancer risk factors Type: general – SubjectFull: Disease risk factors Type: general – SubjectFull: United States Type: general Titles: – TitleFull: Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Steinberg, Karen K. – PersonEntity: Name: NameFull: Relling, Mary V. – PersonEntity: Name: NameFull: Gallagher, Margaret L. – PersonEntity: Name: NameFull: Greene, Christopher N. – PersonEntity: Name: NameFull: Rubin, Carol S. – PersonEntity: Name: NameFull: French, Deborah – PersonEntity: Name: NameFull: Holmes, Adrianne K. – PersonEntity: Name: NameFull: Carroll, William L. – PersonEntity: Name: NameFull: Koontz, Deborah A. – PersonEntity: Name: NameFull: Sampson, Eric J. – PersonEntity: Name: NameFull: Satten, Glen A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 115 – Type: issue Value: 1 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
