Bone Mineral Density Changes in Relation to Environmental PCB Exposure.

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Bibliographic Details
Title:	Bone Mineral Density Changes in Relation to Environmental PCB Exposure.
Authors:	Hodgson, Susan^1,2 susan.hodgson@ncl.ac.uk, Thomas, Laura², Fattore, Elena³, Lind, Monica⁴, Alfven, Tobias⁴, Hellström, Lennart^5,6, Håkansson, Helen⁴, Carubelli, Grazia³, Fanelli, Roberto³, Jarup, Lars²
Source:	Environmental Health Perspectives. Sep2008, Vol. 116 Issue 9, p1162-1166. 5p. 3 Charts.
Subject Terms:	Toxicity testing, Organochlorine compounds, Polychlorinated biphenyls, Environmental exposure, Bone density, Absorption spectra, Blood testing
Abstract:	BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). METHODS: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p´-dichlorophenyldichloroethylene (p,p´-DDE). RESULTS: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than --1) was 1.06 (95% confidence interval, 1.01--1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. CONCLUSIONS: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD. [ABSTRACT FROM AUTHOR]
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Database:	GreenFILE

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Abstract:	BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). METHODS: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p´-dichlorophenyldichloroethylene (p,p´-DDE). RESULTS: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than --1) was 1.06 (95% confidence interval, 1.01--1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. CONCLUSIONS: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD. [ABSTRACT FROM AUTHOR]
ISSN:	00916765
DOI:	10.1289/ehp.11107