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Serum Concentrations of Selected Persistent Organic Pollutants in a Sample of Pregnant Females and Changes in Their Concentrations during Gestation.

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Title: Serum Concentrations of Selected Persistent Organic Pollutants in a Sample of Pregnant Females and Changes in Their Concentrations during Gestation.
Authors: Wang, Richard Y.1 rywang@cdc.gov, Jain, Ram B.1, Wolkin, Amy F.1, Rubin, Carol H.2, Needham, Larry L.1
Source: Environmental Health Perspectives. Aug2009, Vol. 117 Issue 8, p1244-1249. 6p. 5 Charts.
Subject Terms: *Persistent pollutants, *Polychlorinated biphenyls, *Polychlorinated dibenzodioxins, *Polychlorinated dibenzofurans, *Dioxins, Serum, Pregnant women, Pregnancy, Cross-sectional method, Confidence intervals
Geographic Terms: United States
Abstract: Objectives: In this study we evaluated the concentrations of selected persistent organic pollutants in a sample of first-time pregnant females residing in the United States and assessed differences in these concentrations in all pregnant females during gestation. Methods: We reviewed demographic and laboratory data for pregnant females participating in the National Health and Nutrition Examination Survey, including concentrations of 25 polychlorinated biphenyls (PCBs), 6 polychlorinated dibenzo-p-dioxins (PCDDs), 9 polychlorinated dibenzofurans (PCDFs), and 9 organochlorine pesticides. We report serum concentrations for first-time pregnant females (2001—2002; n = 49) and evaluate these concentrations in all pregnant females by trimester (1999—2002; n = 203) using a cross-sectional analysis. Results: The chemicals with = 60% detection included PCBs (congeners 126, 138/158, 153, 180), PCDDs/PCDFs [1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (1234678HpCDD), 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (123678HxCDD), 1,2,3,4,6,7,8-heptachlorodibenzofuran (1234678HpCDF), 1,1'-(2,2-dichloroethenylidene)-bis(4-chlorobenzene) (p,p'-DDE)], and transnonachlor. The geometric mean concentration (95% confidence intervals) for 1234678HpCDD was 15.9 pg/g lipid (5.0-50.6 pg/g); for 123678HxCDD, 9.7 pg/g (5.5—17.1 pg/g); and for 1234678HpCDF, 5.4 pg/g (3.3-8.7 pg/g). The differences in concentrations of these chemicals by trimester were better accounted for with the use of lipid-adjusted units than with wholeweight units; however, the increase in the third-trimester concentration was greater for PCDDs/ PCDFs (123678HxCDD, 1234678HpCDF) than for the highest concentration of indicator PCBs (138/158, 153, 180), even after adjusting for potential confounders. Conclusion: The concentrations of these persistent organic pollutants in a sample of first-time pregnant females living in the United States suggest a decline in exposures to these chemicals since their ban or restricted use and emission. The redistribution of body burden for these and other persistent organic pollutants during pregnancy needs to be more carefully defined to improve the assessment of fetal exposure to them based on maternal serum concentrations. Additional studies are needed to further the understanding of the potential health consequences to the fetus from persistent organic pollutants. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Serum Concentrations of Selected Persistent Organic Pollutants in a Sample of Pregnant Females and Changes in Their Concentrations during Gestation.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Richard+Y%2E%22">Wang, Richard Y.</searchLink><relatesTo>1</relatesTo><i> rywang@cdc.gov</i><br /><searchLink fieldCode="AR" term="%22Jain%2C+Ram+B%2E%22">Jain, Ram B.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wolkin%2C+Amy+F%2E%22">Wolkin, Amy F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rubin%2C+Carol+H%2E%22">Rubin, Carol H.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Needham%2C+Larry+L%2E%22">Needham, Larry L.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Aug2009, Vol. 117 Issue 8, p1244-1249. 6p. 5 Charts.
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  Data: *<searchLink fieldCode="DE" term="%22Persistent+pollutants%22">Persistent pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Polychlorinated+biphenyls%22">Polychlorinated biphenyls</searchLink><br />*<searchLink fieldCode="DE" term="%22Polychlorinated+dibenzodioxins%22">Polychlorinated dibenzodioxins</searchLink><br />*<searchLink fieldCode="DE" term="%22Polychlorinated+dibenzofurans%22">Polychlorinated dibenzofurans</searchLink><br />*<searchLink fieldCode="DE" term="%22Dioxins%22">Dioxins</searchLink><br /><searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnant+women%22">Pregnant women</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
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  Data: Objectives: In this study we evaluated the concentrations of selected persistent organic pollutants in a sample of first-time pregnant females residing in the United States and assessed differences in these concentrations in all pregnant females during gestation. Methods: We reviewed demographic and laboratory data for pregnant females participating in the National Health and Nutrition Examination Survey, including concentrations of 25 polychlorinated biphenyls (PCBs), 6 polychlorinated dibenzo-p-dioxins (PCDDs), 9 polychlorinated dibenzofurans (PCDFs), and 9 organochlorine pesticides. We report serum concentrations for first-time pregnant females (2001—2002; n = 49) and evaluate these concentrations in all pregnant females by trimester (1999—2002; n = 203) using a cross-sectional analysis. Results: The chemicals with = 60% detection included PCBs (congeners 126, 138/158, 153, 180), PCDDs/PCDFs [1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (1234678HpCDD), 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (123678HxCDD), 1,2,3,4,6,7,8-heptachlorodibenzofuran (1234678HpCDF), 1,1'-(2,2-dichloroethenylidene)-bis(4-chlorobenzene) (p,p'-DDE)], and transnonachlor. The geometric mean concentration (95% confidence intervals) for 1234678HpCDD was 15.9 pg/g lipid (5.0-50.6 pg/g); for 123678HxCDD, 9.7 pg/g (5.5—17.1 pg/g); and for 1234678HpCDF, 5.4 pg/g (3.3-8.7 pg/g). The differences in concentrations of these chemicals by trimester were better accounted for with the use of lipid-adjusted units than with wholeweight units; however, the increase in the third-trimester concentration was greater for PCDDs/ PCDFs (123678HxCDD, 1234678HpCDF) than for the highest concentration of indicator PCBs (138/158, 153, 180), even after adjusting for potential confounders. Conclusion: The concentrations of these persistent organic pollutants in a sample of first-time pregnant females living in the United States suggest a decline in exposures to these chemicals since their ban or restricted use and emission. The redistribution of body burden for these and other persistent organic pollutants during pregnancy needs to be more carefully defined to improve the assessment of fetal exposure to them based on maternal serum concentrations. Additional studies are needed to further the understanding of the potential health consequences to the fetus from persistent organic pollutants. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1289/ehp.0800105
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        Text: English
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        Type: general
      – SubjectFull: Polychlorinated biphenyls
        Type: general
      – SubjectFull: Polychlorinated dibenzodioxins
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      – SubjectFull: Polychlorinated dibenzofurans
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      – SubjectFull: Dioxins
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      – SubjectFull: Serum
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      – SubjectFull: Pregnant women
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      – SubjectFull: Pregnancy
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: Confidence intervals
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      – SubjectFull: United States
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      – TitleFull: Serum Concentrations of Selected Persistent Organic Pollutants in a Sample of Pregnant Females and Changes in Their Concentrations during Gestation.
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