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Prenatal Lead Exposure and Weight of 0- to 5-Year-Old Children in Mexico City.

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Title: Prenatal Lead Exposure and Weight of 0- to 5-Year-Old Children in Mexico City.
Authors: Afeiche, Myriam1 mafeiche@hsph.harvard.edu., Peterson, Karen E.1,2, Sánchez, Brisa N.3, Cantonwine, David2, Lamadrid-Figueroa, Héctor4, Schnaas, Lourdes5, Ettinger, Adrienne S.6,7,8, Hernádez-Avila, Mauricio9, Hu, Howard2, Téllez-Rojo, Martha M.4
Source: Environmental Health Perspectives. Oct2011, Vol. 119 Issue 10, p1436-1441. 6p. 3 Charts.
Subject Terms: *Lead, *Lead poisoning, *Environmental exposure, Analysis of variance, Body weight, Chi-squared test, Child development, Children, Confidence intervals, Infant development, Interviewing, Maternal-fetal exchange, Mothers, Patella, Prenatal influences, Regression analysis, Research funding, Sex distribution, Statistics, T-test (Statistics), Tibia, X-ray spectroscopy, Repeated measures design, Data analysis software
Geographic Terms: Mexico
Abstract: Background: Cumulative prenatal lead exposure, as measured by maternal bone lead burden, has been associated with smaller weight of offspring at birth and 1 month of age, but no study has examined whether this effect persists into early childhood. Objective: We investigated the association of perinatal maternal bone lead, a biomarker of cumulative prenatal lead exposure, with children's attained weight over time from birth to 5 years of age. Methods: Children were weighed at birth and at several intervals up until 60 months. Maternal tibia and patella lead were measured at 1 month postpartum using in vivo K-shell X-ray fluorescence. We used varying coefficient models with random effects to assess the association of maternal bone lead with weight trajectories of 522 boys and 477 girls born between 1994 and 2005 in Mexico City. Results: After controlling for breast-feeding duration, maternal anthropometry, and socio- demographic characteristics, a 1-SD increase in maternal patella lead (micrograms per gram) was associated with a 130.9--g decrease in weight [95% confidence interval (CI), -227.4 to -34.4 g] among females and a 13.0--g nonsignificant increase in weight among males (95% CI, -73.7 to 99.9 g) at 5 years of age. These associations were similar after controlling for concurrent blood lead levels between birth and 5 years. Conclusions: Maternal bone lead was associated with lower weight over time among female but not male children up to 5 years of age. Given that the association was evident for patellar but not tibial lead levels, and was limited to females, results need to be confirmed in other studies. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Prenatal Lead Exposure and Weight of 0- to 5-Year-Old Children in Mexico City.
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  Data: <searchLink fieldCode="AR" term="%22Afeiche%2C+Myriam%22">Afeiche, Myriam</searchLink><relatesTo>1</relatesTo><i> mafeiche@hsph.harvard.edu.</i><br /><searchLink fieldCode="AR" term="%22Peterson%2C+Karen+E%2E%22">Peterson, Karen E.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez%2C+Brisa+N%2E%22">Sánchez, Brisa N.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cantonwine%2C+David%22">Cantonwine, David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lamadrid-Figueroa%2C+Héctor%22">Lamadrid-Figueroa, Héctor</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Schnaas%2C+Lourdes%22">Schnaas, Lourdes</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Ettinger%2C+Adrienne+S%2E%22">Ettinger, Adrienne S.</searchLink><relatesTo>6,7,8</relatesTo><br /><searchLink fieldCode="AR" term="%22Hernádez-Avila%2C+Mauricio%22">Hernádez-Avila, Mauricio</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Hu%2C+Howard%22">Hu, Howard</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Téllez-Rojo%2C+Martha+M%2E%22">Téllez-Rojo, Martha M.</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Oct2011, Vol. 119 Issue 10, p1436-1441. 6p. 3 Charts.
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  Data: *<searchLink fieldCode="DE" term="%22Lead%22">Lead</searchLink><br />*<searchLink fieldCode="DE" term="%22Lead+poisoning%22">Lead poisoning</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Body+weight%22">Body weight</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development%22">Child development</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+development%22">Infant development</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal-fetal+exchange%22">Maternal-fetal exchange</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Patella%22">Patella</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+influences%22">Prenatal influences</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Tibia%22">Tibia</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+spectroscopy%22">X-ray spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Repeated+measures+design%22">Repeated measures design</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink>
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  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mexico%22">Mexico</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Cumulative prenatal lead exposure, as measured by maternal bone lead burden, has been associated with smaller weight of offspring at birth and 1 month of age, but no study has examined whether this effect persists into early childhood. Objective: We investigated the association of perinatal maternal bone lead, a biomarker of cumulative prenatal lead exposure, with children's attained weight over time from birth to 5 years of age. Methods: Children were weighed at birth and at several intervals up until 60 months. Maternal tibia and patella lead were measured at 1 month postpartum using in vivo K-shell X-ray fluorescence. We used varying coefficient models with random effects to assess the association of maternal bone lead with weight trajectories of 522 boys and 477 girls born between 1994 and 2005 in Mexico City. Results: After controlling for breast-feeding duration, maternal anthropometry, and socio- demographic characteristics, a 1-SD increase in maternal patella lead (micrograms per gram) was associated with a 130.9--g decrease in weight [95% confidence interval (CI), -227.4 to -34.4 g] among females and a 13.0--g nonsignificant increase in weight among males (95% CI, -73.7 to 99.9 g) at 5 years of age. These associations were similar after controlling for concurrent blood lead levels between birth and 5 years. Conclusions: Maternal bone lead was associated with lower weight over time among female but not male children up to 5 years of age. Given that the association was evident for patellar but not tibial lead levels, and was limited to females, results need to be confirmed in other studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1289/ehp.1003184
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Lead
        Type: general
      – SubjectFull: Lead poisoning
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Body weight
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Child development
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Infant development
        Type: general
      – SubjectFull: Interviewing
        Type: general
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      – SubjectFull: Mothers
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      – SubjectFull: Patella
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      – SubjectFull: Prenatal influences
        Type: general
      – SubjectFull: Regression analysis
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      – SubjectFull: Research funding
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        Type: general
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      – SubjectFull: Repeated measures design
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      – SubjectFull: Mexico
        Type: general
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