A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol. - Fragoso-Saavedra, Sergio; Iruegas-Nunez, David A.; Quintero-Villegas, Alejandro; García-González, H. Benjamín; Nuñez, Isaac; Carbajal-Morelos, Sergio L.; Audelo-Cruz, Belem M.; Arias-Martínez, Sarahi; Caro-Vega, Yanink; Calva, Juan José; Luqueño-Martínez, Verónica; González-Duarte, Alejandra; et al. (BMC Infectious Diseases, 2020)