Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo. - Formichetti, Sara; Sadowska, Agnieszka; Ascolani, Michela; Hansen, Julia; Ganter, Kerstin; Lancrin, Christophe; Humphreys, Neil; Boulard, Mathieu (PLoS Genetics, 2025)