Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms.
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| Title: | Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms. |
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| Authors: | Rayz, V.1 vlrayz@gmail.com, Abla, A.2, Boussel, L.3, Leach, J.1, Acevedo-Bolton, G.1, Saloner, D.1, Lawton, M.2 |
| Source: | Annals of Biomedical Engineering. May2015, Vol. 43 Issue 5, p1210-1222. 13p. |
| Subjects: | Computational fluid dynamics, Magnetic resonance imaging, Vertebrobasilar aneurysms, Hemodynamics, Angiography, Velocimetry, Computer simulation |
| Abstract: | In cases where surgeons consider different interventional options for flow alterations in the setting of pathological basilar artery hemodynamics, a virtual model demonstrating the flow fields resulting from each of these options can assist in making clinical decisions. In this study, image-based computational fluid dynamics (CFD) models were used to simulate the flow in four basilar artery aneurysms in order to evaluate postoperative hemodynamics that would result from flow-altering interventions. Patient-specific geometries were constructed using MR angiography and velocimetry data. CFD simulations carried out for the preoperative flow conditions were compared to in vivo phase-contrast MRI measurements (4D Flow MRI) acquired prior to the interventions. The models were then modified according to the procedures considered for each patient. Numerical simulations of the flow and virtual contrast transport were carried out in each case in order to assess postoperative flow fields and estimate the likelihood of intra-aneurysmal thrombus deposition following the procedures. Postoperative imaging data, when available, were used to validate computational predictions. In two cases, where the aneurysms involved vital pontine perforator arteries branching from the basilar artery, idealized geometries of these vessels were incorporated into the CFD models. The effect of interventions on the flow through the perforators was evaluated by simulating the transport of contrast in these vessels. The computational results were in close agreement with the MR imaging data. In some cases, CFD simulations could help determine which of the surgical options was likely to reduce the flow into the aneurysm while preserving the flow through the basilar trunk. The study demonstrated that image-based computational modeling can provide guidance to clinicians by indicating possible outcome complications and indicating expected success potential for ameliorating pathological aneurysmal flow, prior to a procedure. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 102427065 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rayz%2C+V%2E%22">Rayz, V.</searchLink><relatesTo>1</relatesTo><i> vlrayz@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Abla%2C+A%2E%22">Abla, A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Boussel%2C+L%2E%22">Boussel, L.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Leach%2C+J%2E%22">Leach, J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Acevedo-Bolton%2C+G%2E%22">Acevedo-Bolton, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Saloner%2C+D%2E%22">Saloner, D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lawton%2C+M%2E%22">Lawton, M.</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. May2015, Vol. 43 Issue 5, p1210-1222. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Computational+fluid+dynamics%22">Computational fluid dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Vertebrobasilar+aneurysms%22">Vertebrobasilar aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Angiography%22">Angiography</searchLink><br /><searchLink fieldCode="DE" term="%22Velocimetry%22">Velocimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+simulation%22">Computer simulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In cases where surgeons consider different interventional options for flow alterations in the setting of pathological basilar artery hemodynamics, a virtual model demonstrating the flow fields resulting from each of these options can assist in making clinical decisions. In this study, image-based computational fluid dynamics (CFD) models were used to simulate the flow in four basilar artery aneurysms in order to evaluate postoperative hemodynamics that would result from flow-altering interventions. Patient-specific geometries were constructed using MR angiography and velocimetry data. CFD simulations carried out for the preoperative flow conditions were compared to in vivo phase-contrast MRI measurements (4D Flow MRI) acquired prior to the interventions. The models were then modified according to the procedures considered for each patient. Numerical simulations of the flow and virtual contrast transport were carried out in each case in order to assess postoperative flow fields and estimate the likelihood of intra-aneurysmal thrombus deposition following the procedures. Postoperative imaging data, when available, were used to validate computational predictions. In two cases, where the aneurysms involved vital pontine perforator arteries branching from the basilar artery, idealized geometries of these vessels were incorporated into the CFD models. The effect of interventions on the flow through the perforators was evaluated by simulating the transport of contrast in these vessels. The computational results were in close agreement with the MR imaging data. In some cases, CFD simulations could help determine which of the surgical options was likely to reduce the flow into the aneurysm while preserving the flow through the basilar trunk. The study demonstrated that image-based computational modeling can provide guidance to clinicians by indicating possible outcome complications and indicating expected success potential for ameliorating pathological aneurysmal flow, prior to a procedure. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-014-1170-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1210 Subjects: – SubjectFull: Computational fluid dynamics Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Vertebrobasilar aneurysms Type: general – SubjectFull: Hemodynamics Type: general – SubjectFull: Angiography Type: general – SubjectFull: Velocimetry Type: general – SubjectFull: Computer simulation Type: general Titles: – TitleFull: Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rayz, V. – PersonEntity: Name: NameFull: Abla, A. – PersonEntity: Name: NameFull: Boussel, L. – PersonEntity: Name: NameFull: Leach, J. – PersonEntity: Name: NameFull: Acevedo-Bolton, G. – PersonEntity: Name: NameFull: Saloner, D. – PersonEntity: Name: NameFull: Lawton, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 43 – Type: issue Value: 5 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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