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Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer.

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Title: Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer.
Authors: Kitajima K (AUTHOR), Murakami K (AUTHOR), Yamasaki E (AUTHOR), Domeki Y (AUTHOR), Kaji Y (AUTHOR), Sugimura K (AUTHOR), Kitajima, Kazuhiro1 (AUTHOR), Murakami, Koji (AUTHOR), Yamasaki, Erena (AUTHOR), Domeki, Yasushi (AUTHOR), Kaji, Yasushi (AUTHOR), Sugimura, Kazuro (AUTHOR)
Source: European Radiology. Oct2008, Vol. 18 Issue 10, p2040-2047. 8p.
Abstract: The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer.
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  Data: <searchLink fieldCode="AR" term="%22Kitajima+K%22">Kitajima K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Murakami+K%22">Murakami K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yamasaki+E%22">Yamasaki E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Domeki+Y%22">Domeki Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaji+Y%22">Kaji Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugimura+K%22">Sugimura K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kitajima%2C+Kazuhiro%22">Kitajima, Kazuhiro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Murakami%2C+Koji%22">Murakami, Koji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yamasaki%2C+Erena%22">Yamasaki, Erena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Domeki%2C+Yasushi%22">Domeki, Yasushi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaji%2C+Yasushi%22">Kaji, Yasushi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugimura%2C+Kazuro%22">Sugimura, Kazuro</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2008, Vol. 18 Issue 10, p2040-2047. 8p.
– Name: Abstract
  Label: Abstract
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  Data: The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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