Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids.
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| Title: | Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids. |
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| Authors: | Neoh, Kuang Hong1, Hassan, Ayon Ahmed2, Chen, Anqi1, Sun, Yukun1, Liu, Peng3, Xu, Kai-Feng3 xukf@pumch.cn, Wong, Alice S.T.2 awong1@hku.hk, Han, Ray P.S.1 ray-han@pku.edu.cn |
| Source: | Biomaterials. Jan2018, Vol. 150, p112-124. 13p. |
| Subjects: | Biopsy, Microfluidics, Nucleotide sequence, Clinical pathology |
| Abstract: | Traditionally, liquid biopsy is a blood test involving the harvesting of tumor materials from peripheral blood. Tumor cells from non-blood body fluids have always been clinically available in cytological examinations but limited for use in differential diagnosis due to the low sensitivity of conventional cytopathology. With the recent significant progress in microfluidic and downstream molecular technologies, liquid biopsies have now evolved to include harvesting tumor cells and DNA fragments in all kinds of non-blood body fluids. This expansion into general body fluids presages the notion that liquid biopsy could soon be used in competition, as well as, in complementarity with tissue biopsy. Preliminary research of fluid-harvested tumor materials to spot early-stage tumors, monitor disease progression for metastasis and recurrence, and detect chemoresistance have been reported. To reflect the propagation of tumor cells in non-blood body fluids, we introduced the term Mobile Tumor Cells (MTCs), in lieu of the widely accepted term of circulating tumor cells (CTCs) resident in the bloodstream. Our review starts with a discussion on the clinical significance of MTCs, followed by a presentation of microfluidic techniques for MTC capture and various strategies for their identification. Hopefully, the phenotypic and genomic data acquired from harvested MTCs can be used to guide and improve cancer treatment decisions. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 125859777 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Neoh%2C+Kuang+Hong%22">Neoh, Kuang Hong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hassan%2C+Ayon+Ahmed%22">Hassan, Ayon Ahmed</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chen%2C+Anqi%22">Chen, Anqi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sun%2C+Yukun%22">Sun, Yukun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liu%2C+Peng%22">Liu, Peng</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Kai-Feng%22">Xu, Kai-Feng</searchLink><relatesTo>3</relatesTo><i> xukf@pumch.cn</i><br /><searchLink fieldCode="AR" term="%22Wong%2C+Alice+S%2ET%2E%22">Wong, Alice S.T.</searchLink><relatesTo>2</relatesTo><i> awong1@hku.hk</i><br /><searchLink fieldCode="AR" term="%22Han%2C+Ray+P%2ES%2E%22">Han, Ray P.S.</searchLink><relatesTo>1</relatesTo><i> ray-han@pku.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Jan2018, Vol. 150, p112-124. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Microfluidics%22">Microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleotide+sequence%22">Nucleotide sequence</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+pathology%22">Clinical pathology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Traditionally, liquid biopsy is a blood test involving the harvesting of tumor materials from peripheral blood. Tumor cells from non-blood body fluids have always been clinically available in cytological examinations but limited for use in differential diagnosis due to the low sensitivity of conventional cytopathology. With the recent significant progress in microfluidic and downstream molecular technologies, liquid biopsies have now evolved to include harvesting tumor cells and DNA fragments in all kinds of non-blood body fluids. This expansion into general body fluids presages the notion that liquid biopsy could soon be used in competition, as well as, in complementarity with tissue biopsy. Preliminary research of fluid-harvested tumor materials to spot early-stage tumors, monitor disease progression for metastasis and recurrence, and detect chemoresistance have been reported. To reflect the propagation of tumor cells in non-blood body fluids, we introduced the term Mobile Tumor Cells (MTCs), in lieu of the widely accepted term of circulating tumor cells (CTCs) resident in the bloodstream. Our review starts with a discussion on the clinical significance of MTCs, followed by a presentation of microfluidic techniques for MTC capture and various strategies for their identification. Hopefully, the phenotypic and genomic data acquired from harvested MTCs can be used to guide and improve cancer treatment decisions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biomaterials.2017.10.006 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 112 Subjects: – SubjectFull: Biopsy Type: general – SubjectFull: Microfluidics Type: general – SubjectFull: Nucleotide sequence Type: general – SubjectFull: Clinical pathology Type: general Titles: – TitleFull: Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Neoh, Kuang Hong – PersonEntity: Name: NameFull: Hassan, Ayon Ahmed – PersonEntity: Name: NameFull: Chen, Anqi – PersonEntity: Name: NameFull: Sun, Yukun – PersonEntity: Name: NameFull: Liu, Peng – PersonEntity: Name: NameFull: Xu, Kai-Feng – PersonEntity: Name: NameFull: Wong, Alice S.T. – PersonEntity: Name: NameFull: Han, Ray P.S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 01429612 Numbering: – Type: volume Value: 150 Titles: – TitleFull: Biomaterials Type: main |
| ResultId | 1 |
