Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles.
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| Title: | Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles. |
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| Authors: | Takeuchi, Issei1,2,3, Suzuki, Takaaki1, Makino, Kimiko1,2,3 makino@rs.noda.tus.ac.jp |
| Source: | Colloids & Surfaces B: Biointerfaces. Nov2017, Vol. 159, p312-317. 6p. |
| Subjects: | Transdermal medication, Indomethacin, Nanoparticle synthesis, Skin permeability, Hair follicles |
| Abstract: | Recently, nano-seized systems for transdermal delivery have attracted attention. To efficiently deliver drugs to hair follicles, we focused on poly(DL-lactide- co -glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation. The PLGA nanoparticles prepared using this method are suitable for iontophoresis because of their high surface charge number density. It has been reported that PLGA nanoparticles were delivered to hair follicles by applying iontophoresis, however research on PLGA nanoparticles with a size of less than 100 nm was lacking. In this study, we prepared 50-nm and 100-nm PLGA nanoparticles. Indomethacin was used as a hydrophobic drug model and the nanoparticles were evaluated their skin permeability using the abdominal skin of a rat. Two hours after administration, the skin permeation indomethacin amounts of 50-nm and 100-nm PLGA nanoparticles with iontophoresis were significantly higher than those of passively diffused nanoparticles and indomethacin solution. Moreover, when iontophoresis was applied, the indomethacin concentration in the rat skin of 50-nm PLGA nanoparticles was 1.7 times higher than that of 100-nm PLGA nanoparticles. We also prepared coumarin-6-loaded 50-nm and 100-nm PLGA nanoparticles having surface characteristics equivalent to those of indomethacin-loaded PLGA nanoparticles to investigate transdermal delivery route of indomethacin-loaded PLGA nanoparticles. The 50-nm nanoparticles reached a deeper portion of the hair follicle when applying iontophoresis. Therefore, it was shown that this nanoparticle was useful for targeting to hair follicles. [ABSTRACT FROM AUTHOR] |
| Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 126896670 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Takeuchi%2C+Issei%22">Takeuchi, Issei</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Suzuki%2C+Takaaki%22">Suzuki, Takaaki</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Makino%2C+Kimiko%22">Makino, Kimiko</searchLink><relatesTo>1,2,3</relatesTo><i> makino@rs.noda.tus.ac.jp</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Nov2017, Vol. 159, p312-317. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Transdermal+medication%22">Transdermal medication</searchLink><br /><searchLink fieldCode="DE" term="%22Indomethacin%22">Indomethacin</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticle+synthesis%22">Nanoparticle synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+permeability%22">Skin permeability</searchLink><br /><searchLink fieldCode="DE" term="%22Hair+follicles%22">Hair follicles</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Recently, nano-seized systems for transdermal delivery have attracted attention. To efficiently deliver drugs to hair follicles, we focused on poly(DL-lactide- co -glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation. The PLGA nanoparticles prepared using this method are suitable for iontophoresis because of their high surface charge number density. It has been reported that PLGA nanoparticles were delivered to hair follicles by applying iontophoresis, however research on PLGA nanoparticles with a size of less than 100 nm was lacking. In this study, we prepared 50-nm and 100-nm PLGA nanoparticles. Indomethacin was used as a hydrophobic drug model and the nanoparticles were evaluated their skin permeability using the abdominal skin of a rat. Two hours after administration, the skin permeation indomethacin amounts of 50-nm and 100-nm PLGA nanoparticles with iontophoresis were significantly higher than those of passively diffused nanoparticles and indomethacin solution. Moreover, when iontophoresis was applied, the indomethacin concentration in the rat skin of 50-nm PLGA nanoparticles was 1.7 times higher than that of 100-nm PLGA nanoparticles. We also prepared coumarin-6-loaded 50-nm and 100-nm PLGA nanoparticles having surface characteristics equivalent to those of indomethacin-loaded PLGA nanoparticles to investigate transdermal delivery route of indomethacin-loaded PLGA nanoparticles. The 50-nm nanoparticles reached a deeper portion of the hair follicle when applying iontophoresis. Therefore, it was shown that this nanoparticle was useful for targeting to hair follicles. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.colsurfb.2017.08.003 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 312 Subjects: – SubjectFull: Transdermal medication Type: general – SubjectFull: Indomethacin Type: general – SubjectFull: Nanoparticle synthesis Type: general – SubjectFull: Skin permeability Type: general – SubjectFull: Hair follicles Type: general Titles: – TitleFull: Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Takeuchi, Issei – PersonEntity: Name: NameFull: Suzuki, Takaaki – PersonEntity: Name: NameFull: Makino, Kimiko IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 09277765 Numbering: – Type: volume Value: 159 Titles: – TitleFull: Colloids & Surfaces B: Biointerfaces Type: main |
| ResultId | 1 |
