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CT analysis of the aorta in giant-cell arteritis: a case-control study.

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Title: CT analysis of the aorta in giant-cell arteritis: a case-control study.
Authors: Berthod, Pierre Emmanuel1, Aho-Glélé, Serge2, Ornetti, Paul3, Chevallier, Olivier1, Devilliers, Hervé4, Ricolfi, Frédéric1, Bonnotte, Bernard5, Loffroy, Romaric1,6 romaric.loffroy@chu-dijon.fr, Samson, Maxime5
Source: European Radiology. Sep2018, Vol. 28 Issue 9, p3676-3684. 9p. 1 Color Photograph, 3 Black and White Photographs, 1 Diagram, 4 Charts, 1 Graph.
Subjects: Giant cell arteritis diagnosis, Vasculitis, Computed tomography, Temporal arteries, Biopsy, Diseases
Abstract: Objectives: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA.Methods: Altogether, 174 patients were included (64 with GCA, 43 with polymyalgia rheumatica and 67 controls). All patients had a CT scan at diagnosis or at inclusion for controls. Aortic wall thickness, aortic diameter and scores for atheroma were measured. Assessor was blinded to each patient's group.Results: Aortic diameters and atheroma scores were similar between groups. Aortic wall thickness was greater in the GCA group, even after the exclusion of GCA patients with aortic wall thickness ≥3 mm. The receiver operating characteristic (ROC) curve showed that a wall thickness of 2.2 mm was the optimal threshold to diagnose GCA (sensitivity, 67%; specificity, 98%).Conclusions: Measuring aortic wall thickness by CT scan is effective to diagnose GCA. The optimal threshold to regard aortic wall thickening as pathological was ≥2.2 mm.Key Points: • Imaging, including CT scan, plays an increasing role in GCA diagnosis • CT measurement of aortic wall thickness is useful to diagnose GCA • A 2.2-mm threshold allows the diagnosis of thickened aortic wall in GCA. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: CT analysis of the aorta in giant-cell arteritis: a case-control study.
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  Data: <searchLink fieldCode="AR" term="%22Berthod%2C+Pierre+Emmanuel%22">Berthod, Pierre Emmanuel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Aho-Glélé%2C+Serge%22">Aho-Glélé, Serge</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ornetti%2C+Paul%22">Ornetti, Paul</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Chevallier%2C+Olivier%22">Chevallier, Olivier</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Devilliers%2C+Hervé%22">Devilliers, Hervé</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ricolfi%2C+Frédéric%22">Ricolfi, Frédéric</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bonnotte%2C+Bernard%22">Bonnotte, Bernard</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Loffroy%2C+Romaric%22">Loffroy, Romaric</searchLink><relatesTo>1,6</relatesTo><i> romaric.loffroy@chu-dijon.fr</i><br /><searchLink fieldCode="AR" term="%22Samson%2C+Maxime%22">Samson, Maxime</searchLink><relatesTo>5</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Sep2018, Vol. 28 Issue 9, p3676-3684. 9p. 1 Color Photograph, 3 Black and White Photographs, 1 Diagram, 4 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Giant+cell+arteritis+diagnosis%22">Giant cell arteritis diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Vasculitis%22">Vasculitis</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+arteries%22">Temporal arteries</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink>
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  Label: Abstract
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  Data: <bold>Objectives: </bold>Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA.<bold>Methods: </bold>Altogether, 174 patients were included (64 with GCA, 43 with polymyalgia rheumatica and 67 controls). All patients had a CT scan at diagnosis or at inclusion for controls. Aortic wall thickness, aortic diameter and scores for atheroma were measured. Assessor was blinded to each patient's group.<bold>Results: </bold>Aortic diameters and atheroma scores were similar between groups. Aortic wall thickness was greater in the GCA group, even after the exclusion of GCA patients with aortic wall thickness ≥3 mm. The receiver operating characteristic (ROC) curve showed that a wall thickness of 2.2 mm was the optimal threshold to diagnose GCA (sensitivity, 67%; specificity, 98%).<bold>Conclusions: </bold>Measuring aortic wall thickness by CT scan is effective to diagnose GCA. The optimal threshold to regard aortic wall thickening as pathological was ≥2.2 mm.<bold>Key Points: </bold>• Imaging, including CT scan, plays an increasing role in GCA diagnosis • CT measurement of aortic wall thickness is useful to diagnose GCA • A 2.2-mm threshold allows the diagnosis of thickened aortic wall in GCA. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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