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MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.

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Title: MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.
Authors: Pulickal, Tina1 (AUTHOR), Boos, Johannes1 (AUTHOR) johannes.boos@med.uni-duesseldorf.de, Konieczny, Markus2 (AUTHOR), Sawicki, Lino Morris1 (AUTHOR), Müller-Lutz, Anja1 (AUTHOR), Bittersohl, Bernd2 (AUTHOR), Gerß, Joachim3 (AUTHOR), Eichner, Markus1 (AUTHOR), Wittsack, Hans-Jörg1 (AUTHOR), Antoch, Gerald1 (AUTHOR), Schleich, Christoph1 (AUTHOR)
Source: European Radiology. Dec2019, Vol. 29 Issue 12, p6443-6446. 4p. 1 Diagram.
Subjects: Intervertebral disk, Lumbar pain
Abstract: Key Points: • Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubType: Academic Journal
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  Data: MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.
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  Data: <searchLink fieldCode="AR" term="%22Pulickal%2C+Tina%22">Pulickal, Tina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boos%2C+Johannes%22">Boos, Johannes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> johannes.boos@med.uni-duesseldorf.de</i><br /><searchLink fieldCode="AR" term="%22Konieczny%2C+Markus%22">Konieczny, Markus</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sawicki%2C+Lino+Morris%22">Sawicki, Lino Morris</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller-Lutz%2C+Anja%22">Müller-Lutz, Anja</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bittersohl%2C+Bernd%22">Bittersohl, Bernd</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerß%2C+Joachim%22">Gerß, Joachim</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eichner%2C+Markus%22">Eichner, Markus</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wittsack%2C+Hans-Jörg%22">Wittsack, Hans-Jörg</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Antoch%2C+Gerald%22">Antoch, Gerald</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schleich%2C+Christoph%22">Schleich, Christoph</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Dec2019, Vol. 29 Issue 12, p6443-6446. 4p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Intervertebral+disk%22">Intervertebral disk</searchLink><br /><searchLink fieldCode="DE" term="%22Lumbar+pain%22">Lumbar pain</searchLink>
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  Data: <bold>Key Points: </bold>• Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Dec2019
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