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MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.

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Title: MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.
Authors: Pulickal, Tina1 (AUTHOR), Boos, Johannes1 (AUTHOR) johannes.boos@med.uni-duesseldorf.de, Konieczny, Markus2 (AUTHOR), Sawicki, Lino Morris1 (AUTHOR), Müller-Lutz, Anja1 (AUTHOR), Bittersohl, Bernd2 (AUTHOR), Gerß, Joachim3 (AUTHOR), Eichner, Markus1 (AUTHOR), Wittsack, Hans-Jörg1 (AUTHOR), Antoch, Gerald1 (AUTHOR), Schleich, Christoph1 (AUTHOR)
Source: European Radiology. Dec2019, Vol. 29 Issue 12, p6443-6446. 4p. 1 Diagram.
Subjects: Intervertebral disk, Lumbar pain
Abstract: Key Points: • Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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