X-ray CT in Phase Contrast Enhancement Geometry of Alginate Microbeads in a Whole-Animal Model.
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| Title: | X-ray CT in Phase Contrast Enhancement Geometry of Alginate Microbeads in a Whole-Animal Model. |
|---|---|
| Authors: | Brown, Jacob1 (AUTHOR) she460@my.utsa.edu, Somo, Sami2 (AUTHOR), Brooks, Frank3 (AUTHOR), Komarov, Sergey3 (AUTHOR), Zhou, Weimin3 (AUTHOR), Anastasio, Mark3 (AUTHOR), Brey, Eric1,4 (AUTHOR) |
| Source: | Annals of Biomedical Engineering. Mar2020, Vol. 48 Issue 3, p1016-1024. 9p. 6 Diagrams, 3 Graphs. |
| Subjects: | Microbeads, Computed tomography, Alginic acid, Alginates |
| Abstract: | Imaging soft biomaterials in vivo is a significant challenge, as most conventional techniques are limited by biomaterial contrast, penetration depth, or spatial resolution. Exogeneous contrast agents used to increase contrast may also alter material properties or exhibit local toxicity. The capability to observe biomaterial constructs in vivo without introducing exogenous contrast would improve preclinical testing and evaluation. Conventional X-ray Computed Tomography allows fast, high-resolution imaging at high penetration depth, but biomaterial contrast is low. Previous studies employing X-ray phase contrast (XPC) and utilizing a synchrotron source provided support for the significant potential of XPC in imaging biomaterials without contrast agents. In this study, XPC tomography was used to image alginate hydrogel microspheres within a small animal omental pouch model using a commercially available X-ray source. Multilayer microbeads could be identified in the XPC images with volumetric and structural information not possible in histological analysis. The number of microbeads present and microbead volume and diameter could be quantified from the images. The results of this study show that XPC tomography can be a useful tool for monitoring of implanted soft biomaterials in small animal models. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 141727978 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: X-ray CT in Phase Contrast Enhancement Geometry of Alginate Microbeads in a Whole-Animal Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Brown%2C+Jacob%22">Brown, Jacob</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> she460@my.utsa.edu</i><br /><searchLink fieldCode="AR" term="%22Somo%2C+Sami%22">Somo, Sami</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brooks%2C+Frank%22">Brooks, Frank</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Komarov%2C+Sergey%22">Komarov, Sergey</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Weimin%22">Zhou, Weimin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Anastasio%2C+Mark%22">Anastasio, Mark</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brey%2C+Eric%22">Brey, Eric</searchLink><relatesTo>1,4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Mar2020, Vol. 48 Issue 3, p1016-1024. 9p. 6 Diagrams, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Microbeads%22">Microbeads</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Alginic+acid%22">Alginic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Alginates%22">Alginates</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Imaging soft biomaterials in vivo is a significant challenge, as most conventional techniques are limited by biomaterial contrast, penetration depth, or spatial resolution. Exogeneous contrast agents used to increase contrast may also alter material properties or exhibit local toxicity. The capability to observe biomaterial constructs in vivo without introducing exogenous contrast would improve preclinical testing and evaluation. Conventional X-ray Computed Tomography allows fast, high-resolution imaging at high penetration depth, but biomaterial contrast is low. Previous studies employing X-ray phase contrast (XPC) and utilizing a synchrotron source provided support for the significant potential of XPC in imaging biomaterials without contrast agents. In this study, XPC tomography was used to image alginate hydrogel microspheres within a small animal omental pouch model using a commercially available X-ray source. Multilayer microbeads could be identified in the XPC images with volumetric and structural information not possible in histological analysis. The number of microbeads present and microbead volume and diameter could be quantified from the images. The results of this study show that XPC tomography can be a useful tool for monitoring of implanted soft biomaterials in small animal models. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-019-02291-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1016 Subjects: – SubjectFull: Microbeads Type: general – SubjectFull: Computed tomography Type: general – SubjectFull: Alginic acid Type: general – SubjectFull: Alginates Type: general Titles: – TitleFull: X-ray CT in Phase Contrast Enhancement Geometry of Alginate Microbeads in a Whole-Animal Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brown, Jacob – PersonEntity: Name: NameFull: Somo, Sami – PersonEntity: Name: NameFull: Brooks, Frank – PersonEntity: Name: NameFull: Komarov, Sergey – PersonEntity: Name: NameFull: Zhou, Weimin – PersonEntity: Name: NameFull: Anastasio, Mark – PersonEntity: Name: NameFull: Brey, Eric IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 48 – Type: issue Value: 3 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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