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Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production.

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Title: Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production.
Authors: Shahid, Ayesha1 (AUTHOR), Rehman, Abd ur1 (AUTHOR), Usman, Muhammad1 (AUTHOR), Ashraf, Muhammad Umer Farooq1 (AUTHOR), Javed, Muhammad Rizwan1 (AUTHOR), Khan, Aqib Zafar2 (AUTHOR), Gill, Saba Shahid3 (AUTHOR), Mehmood, Muhammad Aamer1,4 (AUTHOR) draamer@gcuf.edu.pk
Source: Biotechnology & Applied Biochemistry. Jan/Feb2020, Vol. 67 Issue 1, p41-51. 11p.
Subjects: Cetane number, Lipids, Bioengineering, Synthetic biology, Biosynthesis, Conditioned response, Robust control
Abstract: Algal lipids have shown promising feedstock to produce biodiesel due to higher energy content, higher cetane number, and renewable nature. However, at present, the lipid productivity is too low to meet the commercial needs. Various approaches can be employed to enhance the lipid content and lipid productivity in microalgae. Stress manipulation is an attractive option to modify the algal lipid content, but it faces the drawback of time‐consuming production processing and lack of information about molecular mechanisms related to triacylglycerides production in response to stress. Developing the robust hyper lipid accumulating algal strains has gained momentum due to advances in metabolic engineering and synthetic biology tools. Understanding the molecular basis of lipid biosynthesis followed by reorienting the related pathways through genomic modification is an alluring strategy that is believed to achieve the industrial and economic robustness. This review portrays the use of integrated OMIC approaches to elucidate the molecular mechanisms of strain adaptability in response to stress conditions, and identification of molecular pathways that should become novel targets to develop novel algal strains. Moreover, an update on the metabolic engineering approaches to improve the lipid production in microalgae is also provided. [ABSTRACT FROM AUTHOR]
Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production.
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  Data: <searchLink fieldCode="AR" term="%22Shahid%2C+Ayesha%22">Shahid, Ayesha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rehman%2C+Abd+ur%22">Rehman, Abd ur</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Usman%2C+Muhammad%22">Usman, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ashraf%2C+Muhammad+Umer+Farooq%22">Ashraf, Muhammad Umer Farooq</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Javed%2C+Muhammad+Rizwan%22">Javed, Muhammad Rizwan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Aqib+Zafar%22">Khan, Aqib Zafar</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gill%2C+Saba+Shahid%22">Gill, Saba Shahid</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehmood%2C+Muhammad+Aamer%22">Mehmood, Muhammad Aamer</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> draamer@gcuf.edu.pk</i>
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  Data: <searchLink fieldCode="JN" term="%22Biotechnology+%26+Applied+Biochemistry%22">Biotechnology & Applied Biochemistry</searchLink>. Jan/Feb2020, Vol. 67 Issue 1, p41-51. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Cetane+number%22">Cetane number</searchLink><br /><searchLink fieldCode="DE" term="%22Lipids%22">Lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Bioengineering%22">Bioengineering</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+biology%22">Synthetic biology</searchLink><br /><searchLink fieldCode="DE" term="%22Biosynthesis%22">Biosynthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Conditioned+response%22">Conditioned response</searchLink><br /><searchLink fieldCode="DE" term="%22Robust+control%22">Robust control</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Algal lipids have shown promising feedstock to produce biodiesel due to higher energy content, higher cetane number, and renewable nature. However, at present, the lipid productivity is too low to meet the commercial needs. Various approaches can be employed to enhance the lipid content and lipid productivity in microalgae. Stress manipulation is an attractive option to modify the algal lipid content, but it faces the drawback of time‐consuming production processing and lack of information about molecular mechanisms related to triacylglycerides production in response to stress. Developing the robust hyper lipid accumulating algal strains has gained momentum due to advances in metabolic engineering and synthetic biology tools. Understanding the molecular basis of lipid biosynthesis followed by reorienting the related pathways through genomic modification is an alluring strategy that is believed to achieve the industrial and economic robustness. This review portrays the use of integrated OMIC approaches to elucidate the molecular mechanisms of strain adaptability in response to stress conditions, and identification of molecular pathways that should become novel targets to develop novel algal strains. Moreover, an update on the metabolic engineering approaches to improve the lipid production in microalgae is also provided. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/bab.1812
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        Text: English
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        PageCount: 11
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      – SubjectFull: Cetane number
        Type: general
      – SubjectFull: Lipids
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      – SubjectFull: Bioengineering
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      – SubjectFull: Synthetic biology
        Type: general
      – SubjectFull: Biosynthesis
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      – SubjectFull: Conditioned response
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      – SubjectFull: Robust control
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      – TitleFull: Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production.
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            – D: 01
              M: 01
              Text: Jan/Feb2020
              Type: published
              Y: 2020
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