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A responsive microneedle system for efficient anti-melanoma by combining self-enhanced chemodynamic therapy with photothermal therapy.

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Title: A responsive microneedle system for efficient anti-melanoma by combining self-enhanced chemodynamic therapy with photothermal therapy.
Authors: Chen, Jiajie1,2 (AUTHOR), Cao, Yi1,3 (AUTHOR), Lin, Shiyang1 (AUTHOR), Niu, Huicong1,4 (AUTHOR), Zhang, Hongjian1,2 (AUTHOR), Guan, Lei5 (AUTHOR), Shu, Chaoqin1,5 (AUTHOR), Wu, Aijun1,5 (AUTHOR), Bian, Yuhai1,6 (AUTHOR) oceanby@sina.com, Zhu, Yufang1,2 (AUTHOR) zjf2412@163.com
Source: Chemical Engineering Journal. Mar2022:Part 4, Vol. 431, pN.PAG-N.PAG. 1p.
Subjects: Dacarbazine, Hydroxyl group, Copper ions, Hydrogen peroxide, Thermotherapy, Copper oxide
Abstract: • A multifunctional responsive MN system was constructed for anti-melanoma. • MN@CuO 2 system showed good skin-insertion capability and dissolving property. • MN@CuO 2 system can achieve H 2 O 2 self-supplying and GSH depletion-enhanced CDT. • MN@CuO 2 system exhibited excellent NIR photothermal property. • MN@CuO 2 system realized the efficient melanoma inhibition by the combined CDT/PTT. Traditional therapies for melanoma suffer from many restrictions, that calls for the development of new treatments with high effectiveness and safety. Recently, employing transdermal microneedle (MN) systems for delivering therapeutic agents has obtained increasing interest as the efficient, minimally invasive, painless, and safe natures. Designing an "all-in-one" multifunctional MN system without complicated integration that can realize enhanced tumor therapy has presented huge promising for clinical application but is still a challenging strategy. Herein, a simple responsive MN system is developed for efficient anti-melanoma by combining self-enhanced chemodynamic therapy (CDT) and photothermal therapy (PTT). This MN system, constructed by biocompatible poly(vinylpyrrolidone) (PVP) as substrate and PVP-stabilized CuO 2 nanoparticles (CuO 2 NPs) as therapeutic agent, shows good skin-insertion capability and dissolving property that benefit in penetrating skin efficiently to deliver the therapeutic CuO 2 NPs into melanoma site. The released CuO 2 NPs from MN system can not only produce copper ion (Cu2+) and hydrogen peroxide (H 2 O 2) in response to the acidic environment for catalytic hydroxyl radical (OH) generation and thus achieve the H 2 O 2 self-supplying CDT, but also can be utilized as a glutathione (GSH)-scavenging agent for further enhancing CDT. Moreover, owing to the loading of CuO 2 NPs, such MN system exhibits excellent near-infrared (NIR) photothermal property that can induce local hyperthermia at the melanoma area for PTT. In result, the designed MN system realizes the efficient tumor inhibition with minimal side effects in vivo by the combination therapy , offering a safe and effective melanoma treatment option for patients. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 154538350
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: A responsive microneedle system for efficient anti-melanoma by combining self-enhanced chemodynamic therapy with photothermal therapy.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Jiajie%22">Chen, Jiajie</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Yi%22">Cao, Yi</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Shiyang%22">Lin, Shiyang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Niu%2C+Huicong%22">Niu, Huicong</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Hongjian%22">Zhang, Hongjian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guan%2C+Lei%22">Guan, Lei</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shu%2C+Chaoqin%22">Shu, Chaoqin</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Aijun%22">Wu, Aijun</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bian%2C+Yuhai%22">Bian, Yuhai</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<i> oceanby@sina.com</i><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Yufang%22">Zhu, Yufang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> zjf2412@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Engineering+Journal%22">Chemical Engineering Journal</searchLink>. Mar2022:Part 4, Vol. 431, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Dacarbazine%22">Dacarbazine</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyl+group%22">Hydroxyl group</searchLink><br /><searchLink fieldCode="DE" term="%22Copper+ions%22">Copper ions</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+peroxide%22">Hydrogen peroxide</searchLink><br /><searchLink fieldCode="DE" term="%22Thermotherapy%22">Thermotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Copper+oxide%22">Copper oxide</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • A multifunctional responsive MN system was constructed for anti-melanoma. • MN@CuO 2 system showed good skin-insertion capability and dissolving property. • MN@CuO 2 system can achieve H 2 O 2 self-supplying and GSH depletion-enhanced CDT. • MN@CuO 2 system exhibited excellent NIR photothermal property. • MN@CuO 2 system realized the efficient melanoma inhibition by the combined CDT/PTT. Traditional therapies for melanoma suffer from many restrictions, that calls for the development of new treatments with high effectiveness and safety. Recently, employing transdermal microneedle (MN) systems for delivering therapeutic agents has obtained increasing interest as the efficient, minimally invasive, painless, and safe natures. Designing an "all-in-one" multifunctional MN system without complicated integration that can realize enhanced tumor therapy has presented huge promising for clinical application but is still a challenging strategy. Herein, a simple responsive MN system is developed for efficient anti-melanoma by combining self-enhanced chemodynamic therapy (CDT) and photothermal therapy (PTT). This MN system, constructed by biocompatible poly(vinylpyrrolidone) (PVP) as substrate and PVP-stabilized CuO 2 nanoparticles (CuO 2 NPs) as therapeutic agent, shows good skin-insertion capability and dissolving property that benefit in penetrating skin efficiently to deliver the therapeutic CuO 2 NPs into melanoma site. The released CuO 2 NPs from MN system can not only produce copper ion (Cu2+) and hydrogen peroxide (H 2 O 2) in response to the acidic environment for catalytic hydroxyl radical (OH) generation and thus achieve the H 2 O 2 self-supplying CDT, but also can be utilized as a glutathione (GSH)-scavenging agent for further enhancing CDT. Moreover, owing to the loading of CuO 2 NPs, such MN system exhibits excellent near-infrared (NIR) photothermal property that can induce local hyperthermia at the melanoma area for PTT. In result, the designed MN system realizes the efficient tumor inhibition with minimal side effects in vivo by the combination therapy , offering a safe and effective melanoma treatment option for patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.cej.2021.133466
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Dacarbazine
        Type: general
      – SubjectFull: Hydroxyl group
        Type: general
      – SubjectFull: Copper ions
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      – SubjectFull: Hydrogen peroxide
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      – SubjectFull: Thermotherapy
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      – SubjectFull: Copper oxide
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      – TitleFull: A responsive microneedle system for efficient anti-melanoma by combining self-enhanced chemodynamic therapy with photothermal therapy.
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              Text: Mar2022:Part 4
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