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Predictive Value of Health-Related Quality of Life on Radiotherapy Related Toxicities in Patients with Head and Neck Cancer.

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Title: Predictive Value of Health-Related Quality of Life on Radiotherapy Related Toxicities in Patients with Head and Neck Cancer.
Authors: Billa, O.1 (AUTHOR), Bonnetain, F.2 (AUTHOR), Chamois, J.3 (AUTHOR), Ligey, A.4 (AUTHOR), Ganansia, V.5 (AUTHOR), Renard, S.6 (AUTHOR), Quivrin, M.7 (AUTHOR), Truntzer, P.5 (AUTHOR), Vulquin, N.7 (AUTHOR), Noel, G.5 (AUTHOR), Maingon, P.8 (AUTHOR), Dabakuyo-Yonli, S.T.1 (AUTHOR)
Source: International Journal of Radiation Oncology, Biology, Physics. Apr2022, Vol. 112 Issue 5, pe62-e62. 1p.
Subjects: Radiotherapy complications, Quality of life, Oncologic surgery, Head & neck cancer, Physical mobility, Appetite loss, Adjuvant chemotherapy
Geographic Terms: France
Abstract: aims to assess the association between baseline HRQOL and occurrence of major toxicities in patients with head and neck cancer (HNC). The present study analyzed data from randomized study investigating the utility of HRQoL assessment. Patients with HNC treated by radiotherapy were included from May 2009 to September 2014 in 4 centers in France. At baseline and during follow-up patients were completed QLQ-C30 questionnaire. According to NCI-CTCAE classification, we defined major toxicities as adverse events of grade ≥3 including skin, digestive, general, hematological head/neck toxicities and death related to an adverse event. Cox proportional-hazards regression analyses were performed in two step to assess association between baseline HRQoL score and major toxicities. Firstly Manual backward selection was performed to determine clinical and sociodemographic factors associated with major toxicities with a p-value <0.05 by multivariable analysis. Secondly each baseline HRQOL dimension selected in univariable have been adjusted on variables included in multivariable model based on clinical and sociodemographic data to determine predictive value of HRQOL on major toxicities and value of p <0.05 was considered as statistically significant. The HRQOL scores were included as continuous variables and hazard ratios were calculated for each increase of 10 points in HRQOL. Out of 200 patients included, the median age was 59.6 years, 79.5% had comorbidities, 55.6% received adjuvant chemotherapy and 90.4% underwent surgery. At baseline, global health status mean score was 67.03 (SD=19.28), the best functioning score was physical functioning (FP) with means of 87.92 (24.35) and the worst symptom score was insomnia with mean score of 31.67 (32.06). The median follow-up was 24 months (range 1.91 to 28.5 months). During follow up, 41 patients (20.5%) developed at least one major toxicity. In multivariable analyses, for each significant HRQoL scales adjusted on model based on clinical and sociodemographic data (age, Center with at least 30 patients included, cancer site, cancer stage, chemotherapy and surgery), a 10-point increase score in the FP (HR: 0.76, 95% CI [0.62 to 0.94], p=0.009), role functioning (HR: 0.87, 95% CI [0.77 to 0.98], p=0.032) and social functioning (HR: 0.88, 95% CI [0.77 to 0.99], p=0.047) were associated with a lower risk of occurrence of major toxicities, while a 10-point increase score in dyspnea (HR: 1.15, 95% CI [1.03 to 1.30], p=0.014), and loss of appetite (HR: 1.16, 95% CI [1.03 to 1.32], p=0.013) were associated with an increased risk of occurrence of major toxicities Some baseline HRQoL scores were predictive factors of major toxicities and HRQOL should be assessed before treatment to identify patients at risk to develop radiotherapy related toxicities in patients with HNC. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Predictive Value of Health-Related Quality of Life on Radiotherapy Related Toxicities in Patients with Head and Neck Cancer.
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  Data: aims to assess the association between baseline HRQOL and occurrence of major toxicities in patients with head and neck cancer (HNC). The present study analyzed data from randomized study investigating the utility of HRQoL assessment. Patients with HNC treated by radiotherapy were included from May 2009 to September 2014 in 4 centers in France. At baseline and during follow-up patients were completed QLQ-C30 questionnaire. According to NCI-CTCAE classification, we defined major toxicities as adverse events of grade ≥3 including skin, digestive, general, hematological head/neck toxicities and death related to an adverse event. Cox proportional-hazards regression analyses were performed in two step to assess association between baseline HRQoL score and major toxicities. Firstly Manual backward selection was performed to determine clinical and sociodemographic factors associated with major toxicities with a p-value &lt;0.05 by multivariable analysis. Secondly each baseline HRQOL dimension selected in univariable have been adjusted on variables included in multivariable model based on clinical and sociodemographic data to determine predictive value of HRQOL on major toxicities and value of p &lt;0.05 was considered as statistically significant. The HRQOL scores were included as continuous variables and hazard ratios were calculated for each increase of 10 points in HRQOL. Out of 200 patients included, the median age was 59.6 years, 79.5% had comorbidities, 55.6% received adjuvant chemotherapy and 90.4% underwent surgery. At baseline, global health status mean score was 67.03 (SD=19.28), the best functioning score was physical functioning (FP) with means of 87.92 (24.35) and the worst symptom score was insomnia with mean score of 31.67 (32.06). The median follow-up was 24 months (range 1.91 to 28.5 months). During follow up, 41 patients (20.5%) developed at least one major toxicity. In multivariable analyses, for each significant HRQoL scales adjusted on model based on clinical and sociodemographic data (age, Center with at least 30 patients included, cancer site, cancer stage, chemotherapy and surgery), a 10-point increase score in the FP (HR: 0.76, 95% CI [0.62 to 0.94], p=0.009), role functioning (HR: 0.87, 95% CI [0.77 to 0.98], p=0.032) and social functioning (HR: 0.88, 95% CI [0.77 to 0.99], p=0.047) were associated with a lower risk of occurrence of major toxicities, while a 10-point increase score in dyspnea (HR: 1.15, 95% CI [1.03 to 1.30], p=0.014), and loss of appetite (HR: 1.16, 95% CI [1.03 to 1.32], p=0.013) were associated with an increased risk of occurrence of major toxicities Some baseline HRQoL scores were predictive factors of major toxicities and HRQOL should be assessed before treatment to identify patients at risk to develop radiotherapy related toxicities in patients with HNC. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: English
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