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Ultrasensitive Nanophotonic Random Spectrometer with Microfluidic Channels as a Sensor for Biological Applications.

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Title: Ultrasensitive Nanophotonic Random Spectrometer with Microfluidic Channels as a Sensor for Biological Applications.
Authors: Kuzin, Aleksei1,2 (AUTHOR) aleksei.kuzin@skoltech.ru, Fradkin, Ilia3,4 (AUTHOR), Chernyshev, Vasiliy1 (AUTHOR), Kovalyuk, Vadim5,6 (AUTHOR), An, Pavel2,7 (AUTHOR), Golikov, Alexander2,5 (AUTHOR), Florya, Irina5 (AUTHOR), Gippius, Nikolay3 (AUTHOR), Gorin, Dmitry1 (AUTHOR), Goltsman, Gregory6,7 (AUTHOR)
Source: Nanomaterials (2079-4991). Jan2023, Vol. 13 Issue 1, p81. 10p.
Subjects: Optical radiometry, Optical sensors, Biosensors, Optical polarization, Spectrometers, Optical properties
Abstract: Spectrometers are widely used tools in chemical and biological sensing, material analysis, and light source characterization. However, an important characteristic of traditional spectrometers for biomedical applications is stable operation. It can be achieved due to high fabrication control during the development and stabilization of temperature and polarization of optical radiation during measurements. Temperature and polarization stabilization can be achieved through on-chip technology, and in turn robustness against fabrication imperfections through sensor design. Here, for the first time, we introduce a robust sensor based on a combination of nanophotonic random spectrometer and microfluidics (NRSM) for determining ultra-low concentrations of analyte in a solution. In order to study the sensor, we measure and analyze the spectra of different isopropanol solutions of known refractive indexes. Simple correlation analysis shows that the measured spectra shift with a tiny variation of the ambient liquid optical properties reaches a sensitivity of approximately 61.8 ± 2.3 nm/RIU. Robustness against fabrication imperfections leads to great scalability on a chip and the ability to operate in a huge spectral range from VIS to mid-IR. NRSM optical sensors are very promising for fast and efficient functionalization in the field of selective capture fluorescence-free oncological disease for liquid/gas biopsy in on-chip theranostics applications. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Ultrasensitive Nanophotonic Random Spectrometer with Microfluidic Channels as a Sensor for Biological Applications.
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jan2023, Vol. 13 Issue 1, p81. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Optical+radiometry%22">Optical radiometry</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+sensors%22">Optical sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+polarization%22">Optical polarization</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrometers%22">Spectrometers</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+properties%22">Optical properties</searchLink>
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  Data: Spectrometers are widely used tools in chemical and biological sensing, material analysis, and light source characterization. However, an important characteristic of traditional spectrometers for biomedical applications is stable operation. It can be achieved due to high fabrication control during the development and stabilization of temperature and polarization of optical radiation during measurements. Temperature and polarization stabilization can be achieved through on-chip technology, and in turn robustness against fabrication imperfections through sensor design. Here, for the first time, we introduce a robust sensor based on a combination of nanophotonic random spectrometer and microfluidics (NRSM) for determining ultra-low concentrations of analyte in a solution. In order to study the sensor, we measure and analyze the spectra of different isopropanol solutions of known refractive indexes. Simple correlation analysis shows that the measured spectra shift with a tiny variation of the ambient liquid optical properties reaches a sensitivity of approximately 61.8 ± 2.3 nm/RIU. Robustness against fabrication imperfections leads to great scalability on a chip and the ability to operate in a huge spectral range from VIS to mid-IR. NRSM optical sensors are very promising for fast and efficient functionalization in the field of selective capture fluorescence-free oncological disease for liquid/gas biopsy in on-chip theranostics applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano13010081
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        Text: English
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        PageCount: 10
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    Subjects:
      – SubjectFull: Optical radiometry
        Type: general
      – SubjectFull: Optical sensors
        Type: general
      – SubjectFull: Biosensors
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      – SubjectFull: Optical polarization
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      – SubjectFull: Spectrometers
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      – SubjectFull: Optical properties
        Type: general
    Titles:
      – TitleFull: Ultrasensitive Nanophotonic Random Spectrometer with Microfluidic Channels as a Sensor for Biological Applications.
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            – D: 01
              M: 01
              Text: Jan2023
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