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Fractional myocardial blood volume by ferumoxytol‐enhanced MRI: Estimation of ischemic burden.

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Title: Fractional myocardial blood volume by ferumoxytol‐enhanced MRI: Estimation of ischemic burden.
Authors: Colbert, Caroline M.1,2 (AUTHOR), Hollowed, John J.2 (AUTHOR), Nguyen, Dylan N.3 (AUTHOR), Duarte‐Vogel, Sandra4 (AUTHOR), Dahlbom, Magnus1,5 (AUTHOR), Hu, Peng1,6 (AUTHOR), Nguyen, Kim‐Lien1,2,6 (AUTHOR) klnguyen@ucla.edu
Source: Magnetic Resonance in Medicine. Apr2023, Vol. 89 Issue 4, p1557-1566. 10p.
Subjects: Blood volume, Coronary artery stenosis, Receiver operating characteristic curves, Magnetic resonance imaging, Sex (Biology)
Abstract: Purpose: To investigate model‐fitted fractional myocardial blood volume (fMBV) derived from ferumoxytol‐enhanced MRI as a measure of myocardial tissue hypoperfusion at rest. Methods: We artificially induced moderate to severe focal coronary stenosis in the left anterior descending artery of 19 swine by percutaneous delivery of a 3D‐printed coronary implant. Using the MOLLI pulse sequence, we acquired T1 maps at 3 T after multiple incremental ferumoxytol doses (0.0–4.0 mg/kg). We computed pixel‐wise fMBV using a multi‐compartmental modeling approach in 19 ischemic swine and 4 healthy swine. Results: Ischemic myocardial segments showed a mean MRI‐fMBV of 11.72 ± 3.00%, compared with 8.23 ± 2.12% in remote segments and 8.38 ± 2.23% in normal segments. Ischemic segments showed a restricted transvascular water‐exchange rate (ki = 15.32 ± 8.69 s−1) relative to remote segments (ki = 17.78 [11.60, 26.36] s−1). A mixed‐effects model found significant difference in fMBV (p = 0.002) and water‐exchange rate (p < 0.001) between ischemic and remote myocardial regions after adjusting for biological sex and slice location. Analysis of fMBV as a predictor of impaired myocardial contractility using receiver operating characteristics showed an area under the curve of 0.89 (95% confidence interval [CI] 0.80, 0.95). An MRI‐fMBV threshold of 9.60% has a specificity of 90.0% (95% CI 76.3, 97.2) and a sensitivity of 72.5% (95% CI 56.1, 83.4) for prediction of impaired myocardial contractility. Conclusions: Model‐fitted fMBV derived from ferumoxytol‐enhanced MRI can distinguish regions of ischemia from remote myocardium in a swine model of myocardial hypoperfusion. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Fractional myocardial blood volume by ferumoxytol‐enhanced MRI: Estimation of ischemic burden.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Colbert%2C+Caroline+M%2E%22&quot;&gt;Colbert, Caroline M.&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hollowed%2C+John+J%2E%22&quot;&gt;Hollowed, John J.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nguyen%2C+Dylan+N%2E%22&quot;&gt;Nguyen, Dylan N.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duarte‐Vogel%2C+Sandra%22&quot;&gt;Duarte‐Vogel, Sandra&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dahlbom%2C+Magnus%22&quot;&gt;Dahlbom, Magnus&lt;/searchLink&gt;&lt;relatesTo&gt;1,5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Peng%22&quot;&gt;Hu, Peng&lt;/searchLink&gt;&lt;relatesTo&gt;1,6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nguyen%2C+Kim‐Lien%22&quot;&gt;Nguyen, Kim‐Lien&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,6&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; klnguyen@ucla.edu&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Apr2023, Vol. 89 Issue 4, p1557-1566. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+volume%22&quot;&gt;Blood volume&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+artery+stenosis%22&quot;&gt;Coronary artery stenosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Receiver+operating+characteristic+curves%22&quot;&gt;Receiver operating characteristic curves&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sex+%28Biology%29%22&quot;&gt;Sex (Biology)&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To investigate model‐fitted fractional myocardial blood volume (fMBV) derived from ferumoxytol‐enhanced MRI as a measure of myocardial tissue hypoperfusion at rest. Methods: We artificially induced moderate to severe focal coronary stenosis in the left anterior descending artery of 19 swine by percutaneous delivery of a 3D‐printed coronary implant. Using the MOLLI pulse sequence, we acquired T1 maps at 3 T after multiple incremental ferumoxytol doses (0.0–4.0 mg/kg). We computed pixel‐wise fMBV using a multi‐compartmental modeling approach in 19 ischemic swine and 4 healthy swine. Results: Ischemic myocardial segments showed a mean MRI‐fMBV of 11.72 &#177; 3.00%, compared with 8.23 &#177; 2.12% in remote segments and 8.38 &#177; 2.23% in normal segments. Ischemic segments showed a restricted transvascular water‐exchange rate (ki = 15.32 &#177; 8.69 s−1) relative to remote segments (ki = 17.78 [11.60, 26.36] s−1). A mixed‐effects model found significant difference in fMBV (p = 0.002) and water‐exchange rate (p &lt; 0.001) between ischemic and remote myocardial regions after adjusting for biological sex and slice location. Analysis of fMBV as a predictor of impaired myocardial contractility using receiver operating characteristics showed an area under the curve of 0.89 (95% confidence interval [CI] 0.80, 0.95). An MRI‐fMBV threshold of 9.60% has a specificity of 90.0% (95% CI 76.3, 97.2) and a sensitivity of 72.5% (95% CI 56.1, 83.4) for prediction of impaired myocardial contractility. Conclusions: Model‐fitted fMBV derived from ferumoxytol‐enhanced MRI can distinguish regions of ischemia from remote myocardium in a swine model of myocardial hypoperfusion. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29530
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        Text: English
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        StartPage: 1557
    Subjects:
      – SubjectFull: Blood volume
        Type: general
      – SubjectFull: Coronary artery stenosis
        Type: general
      – SubjectFull: Receiver operating characteristic curves
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Sex (Biology)
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    Titles:
      – TitleFull: Fractional myocardial blood volume by ferumoxytol‐enhanced MRI: Estimation of ischemic burden.
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            NameFull: Hu, Peng
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              Text: Apr2023
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              Y: 2023
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