View in EDS HTML Full Text PDF Full Text

Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats.

Saved in:
Bibliographic Details
Title: Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats.
Authors: Sulumer, Ayşe Nurseli1 (AUTHOR), Palabıyık, Esra1 (AUTHOR), Avcı, Bahri1 (AUTHOR), Uguz, Handan1 (AUTHOR), Demir, Yeliz2 (AUTHOR) yelizdemir2116@gmail.com, Serhat Özaslan, Muhammet2 (AUTHOR), Aşkın, Hakan1 (AUTHOR)
Source: Biotechnology & Applied Biochemistry. Feb2024, Vol. 71 Issue 1, p17-27. 11p.
Subjects: Bromelin, Acetylcholinesterase, Blood lipids, Aldose reductase, Enzymes, Glutathione transferase, Glutathione reductase
Abstract: Elevation of one or more plasma lipids, such as phospholipids, cholesterol esters, cholesterol, and triglycerides, is known as hyperlipidemia. In humans and experimental animals, bromelain, the primary active ingredient isolated from pineapple stems, has several positive effects, including anti‐tumor growth, anticoagulation, and anti‐inflammation. Hence, the purpose of this study was to determine the possible protective impact of bromelain on some metabolic enzymes (paraoxonase‐1, glutathione S‐transferase, glutathione reductase, sorbitol dehydrogenase [SDH], aldose reductase [AR], butyrylcholinesterase [BChE], and acetylcholinesterase [AChE]), activity in the heart, kidney, and liver of rats with tyloxapol‐induced hyperlipidemia. Rats were divided into three groups: control group, HL‐control group (tyloxapol 400 mg/kg, i.p. administered group), and HL+bromelain (group receiving bromelain 250 mg/kg/o.d. prior to administration of tyloxapol 400 mg/kg, i.p.). BChE, SDH, and AR enzyme activities were significantly increased in all tissues in HL‐control compared to the control, whereas the activity of other studied enzymes was significantly decreased. Bromelain had a regulatory effect on all tissues and enzyme activities. In conclusion, these results prove that bromelain is a new mediator that decreases hyperlipidemia. [ABSTRACT FROM AUTHOR]
Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 175304332
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sulumer%2C+Ayşe+Nurseli%22">Sulumer, Ayşe Nurseli</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palabıyık%2C+Esra%22">Palabıyık, Esra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avcı%2C+Bahri%22">Avcı, Bahri</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uguz%2C+Handan%22">Uguz, Handan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Demir%2C+Yeliz%22">Demir, Yeliz</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> yelizdemir2116@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Serhat+Özaslan%2C+Muhammet%22">Serhat Özaslan, Muhammet</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aşkın%2C+Hakan%22">Aşkın, Hakan</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Biotechnology+%26+Applied+Biochemistry%22">Biotechnology & Applied Biochemistry</searchLink>. Feb2024, Vol. 71 Issue 1, p17-27. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bromelin%22">Bromelin</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholinesterase%22">Acetylcholinesterase</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+lipids%22">Blood lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Aldose+reductase%22">Aldose reductase</searchLink><br /><searchLink fieldCode="DE" term="%22Enzymes%22">Enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione+transferase%22">Glutathione transferase</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione+reductase%22">Glutathione reductase</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Elevation of one or more plasma lipids, such as phospholipids, cholesterol esters, cholesterol, and triglycerides, is known as hyperlipidemia. In humans and experimental animals, bromelain, the primary active ingredient isolated from pineapple stems, has several positive effects, including anti‐tumor growth, anticoagulation, and anti‐inflammation. Hence, the purpose of this study was to determine the possible protective impact of bromelain on some metabolic enzymes (paraoxonase‐1, glutathione S‐transferase, glutathione reductase, sorbitol dehydrogenase [SDH], aldose reductase [AR], butyrylcholinesterase [BChE], and acetylcholinesterase [AChE]), activity in the heart, kidney, and liver of rats with tyloxapol‐induced hyperlipidemia. Rats were divided into three groups: control group, HL‐control group (tyloxapol 400 mg/kg, i.p. administered group), and HL+bromelain (group receiving bromelain 250 mg/kg/o.d. prior to administration of tyloxapol 400 mg/kg, i.p.). BChE, SDH, and AR enzyme activities were significantly increased in all tissues in HL‐control compared to the control, whereas the activity of other studied enzymes was significantly decreased. Bromelain had a regulatory effect on all tissues and enzyme activities. In conclusion, these results prove that bromelain is a new mediator that decreases hyperlipidemia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=175304332
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/bab.2517
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 17
    Subjects:
      – SubjectFull: Bromelin
        Type: general
      – SubjectFull: Acetylcholinesterase
        Type: general
      – SubjectFull: Blood lipids
        Type: general
      – SubjectFull: Aldose reductase
        Type: general
      – SubjectFull: Enzymes
        Type: general
      – SubjectFull: Glutathione transferase
        Type: general
      – SubjectFull: Glutathione reductase
        Type: general
    Titles:
      – TitleFull: Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sulumer, Ayşe Nurseli
      – PersonEntity:
          Name:
            NameFull: Palabıyık, Esra
      – PersonEntity:
          Name:
            NameFull: Avcı, Bahri
      – PersonEntity:
          Name:
            NameFull: Uguz, Handan
      – PersonEntity:
          Name:
            NameFull: Demir, Yeliz
      – PersonEntity:
          Name:
            NameFull: Serhat Özaslan, Muhammet
      – PersonEntity:
          Name:
            NameFull: Aşkın, Hakan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 08854513
          Numbering:
            – Type: volume
              Value: 71
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Biotechnology & Applied Biochemistry
              Type: main
ResultId 1