View in EDS HTML Full Text PDF Full Text

Split scar sign to predict complete response in rectal cancer after neoadjuvant chemoradiotherapy: systematic review and meta-analysis.

Saved in:
Bibliographic Details
Title: Split scar sign to predict complete response in rectal cancer after neoadjuvant chemoradiotherapy: systematic review and meta-analysis.
Authors: Torri, Giovanni Brondani1 (AUTHOR), Wiethan, Camila Piovesan1 (AUTHOR), Langer, Felipe Welter1 (AUTHOR), de Oliveira, Guilherme Strieder2 (AUTHOR), Meirelles, Alice Villa Bella3 (AUTHOR), Horvat, Natally4 (AUTHOR), Tse, Justin Ruey5 (AUTHOR), Dias, Adriano Basso6 (AUTHOR), Altmayer, Stephan5 (AUTHOR) altmayer@stanford.edu
Source: European Radiology. Jun2024, Vol. 34 Issue 6, p3874-3881. 8p.
Subjects: Rectal cancer, Abdominoperineal resection, Chemoradiotherapy, Magnetic resonance imaging, Neoadjuvant chemotherapy, Scars, Tumor classification, Clinical pathology
Abstract: Objectives: Magnetic resonance imaging (MRI) is the modality of choice for rectal cancer initial staging and restaging after neoadjuvant chemoradiation. Our objective was to perform a meta-analysis of the diagnostic performance of the split scar sign (SSS) on rectal MRI in predicting complete response after neoadjuvant therapy. Methods: MEDLINE, EMBASE, and Cochrane databases were searched for relevant published studies through June 2023. Primary studies met eligibility criteria if they evaluated the diagnostic performance of the SSS to predict complete response on pathology or clinical follow-up in patients undergoing neoadjuvant chemoradiation. A meta-analysis with a random-effects model was used to estimate pooled sensitivity and specificity, area under the curve (AUC), and diagnostic odds ratio (DOR) of the SSS. Results: A total of 4 studies comprising 377 patients met the inclusion criteria. The prevalence of complete response in the studies was 21.7–52.5%. The pooled sensitivity and specificity of the SSS to predict complete response were 62.0% (95% CI, 43.5–78.5%) and 91.9% (95% CI, 78.9–97.2%), respectively. The estimated AUC for SSS was 0.83 (95% CI, 0.56–0.94) with a DOR of 18.8 (95% CI, 3.65–96.5). Conclusion: The presence of SSS on rectal MRI demonstrated high specificity for complete response in patients with rectal cancer after neoadjuvant chemoradiation. This imaging pattern can be a valuable tool to identify potential candidates for organ-sparing treatment and surveillance. Clinical relevance statement: SSS presents high specificity for complete response post-neoadjuvant. This MRI finding enhances rectal cancer treatment assessment and aids clinicians and patients in choosing watch-and-wait over immediate surgery, which can potentially reduce costs and associated morbidity. Key Points: •Fifteen to 50% of rectal cancer patients achieve complete response after neoadjuvant chemoradiation and may be eligible for a watch-and-wait strategy. •The split scar sign has high specificity for a complete response. •This imaging finding is valuable to select candidates for organ-sparing management. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 177797517
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Split scar sign to predict complete response in rectal cancer after neoadjuvant chemoradiotherapy: systematic review and meta-analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Torri%2C+Giovanni+Brondani%22">Torri, Giovanni Brondani</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiethan%2C+Camila+Piovesan%22">Wiethan, Camila Piovesan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Langer%2C+Felipe+Welter%22">Langer, Felipe Welter</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Oliveira%2C+Guilherme+Strieder%22">de Oliveira, Guilherme Strieder</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meirelles%2C+Alice+Villa+Bella%22">Meirelles, Alice Villa Bella</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Horvat%2C+Natally%22">Horvat, Natally</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tse%2C+Justin+Ruey%22">Tse, Justin Ruey</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dias%2C+Adriano+Basso%22">Dias, Adriano Basso</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Altmayer%2C+Stephan%22">Altmayer, Stephan</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> altmayer@stanford.edu</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jun2024, Vol. 34 Issue 6, p3874-3881. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Rectal+cancer%22">Rectal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Abdominoperineal+resection%22">Abdominoperineal resection</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoradiotherapy%22">Chemoradiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Neoadjuvant+chemotherapy%22">Neoadjuvant chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Scars%22">Scars</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+classification%22">Tumor classification</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+pathology%22">Clinical pathology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Magnetic resonance imaging (MRI) is the modality of choice for rectal cancer initial staging and restaging after neoadjuvant chemoradiation. Our objective was to perform a meta-analysis of the diagnostic performance of the split scar sign (SSS) on rectal MRI in predicting complete response after neoadjuvant therapy. Methods: MEDLINE, EMBASE, and Cochrane databases were searched for relevant published studies through June 2023. Primary studies met eligibility criteria if they evaluated the diagnostic performance of the SSS to predict complete response on pathology or clinical follow-up in patients undergoing neoadjuvant chemoradiation. A meta-analysis with a random-effects model was used to estimate pooled sensitivity and specificity, area under the curve (AUC), and diagnostic odds ratio (DOR) of the SSS. Results: A total of 4 studies comprising 377 patients met the inclusion criteria. The prevalence of complete response in the studies was 21.7–52.5%. The pooled sensitivity and specificity of the SSS to predict complete response were 62.0% (95% CI, 43.5–78.5%) and 91.9% (95% CI, 78.9–97.2%), respectively. The estimated AUC for SSS was 0.83 (95% CI, 0.56–0.94) with a DOR of 18.8 (95% CI, 3.65–96.5). Conclusion: The presence of SSS on rectal MRI demonstrated high specificity for complete response in patients with rectal cancer after neoadjuvant chemoradiation. This imaging pattern can be a valuable tool to identify potential candidates for organ-sparing treatment and surveillance. Clinical relevance statement: SSS presents high specificity for complete response post-neoadjuvant. This MRI finding enhances rectal cancer treatment assessment and aids clinicians and patients in choosing watch-and-wait over immediate surgery, which can potentially reduce costs and associated morbidity. Key Points: •Fifteen to 50% of rectal cancer patients achieve complete response after neoadjuvant chemoradiation and may be eligible for a watch-and-wait strategy. •The split scar sign has high specificity for a complete response. •This imaging finding is valuable to select candidates for organ-sparing management. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=177797517
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00330-023-10447-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 3874
    Subjects:
      – SubjectFull: Rectal cancer
        Type: general
      – SubjectFull: Abdominoperineal resection
        Type: general
      – SubjectFull: Chemoradiotherapy
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Neoadjuvant chemotherapy
        Type: general
      – SubjectFull: Scars
        Type: general
      – SubjectFull: Tumor classification
        Type: general
      – SubjectFull: Clinical pathology
        Type: general
    Titles:
      – TitleFull: Split scar sign to predict complete response in rectal cancer after neoadjuvant chemoradiotherapy: systematic review and meta-analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Torri, Giovanni Brondani
      – PersonEntity:
          Name:
            NameFull: Wiethan, Camila Piovesan
      – PersonEntity:
          Name:
            NameFull: Langer, Felipe Welter
      – PersonEntity:
          Name:
            NameFull: de Oliveira, Guilherme Strieder
      – PersonEntity:
          Name:
            NameFull: Meirelles, Alice Villa Bella
      – PersonEntity:
          Name:
            NameFull: Horvat, Natally
      – PersonEntity:
          Name:
            NameFull: Tse, Justin Ruey
      – PersonEntity:
          Name:
            NameFull: Dias, Adriano Basso
      – PersonEntity:
          Name:
            NameFull: Altmayer, Stephan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1