Exploring photobiomodulation in the management of bowel diseases: a concise critical review.
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| Title: | Exploring photobiomodulation in the management of bowel diseases: a concise critical review. |
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| Authors: | De Souza, Vanessa1 (AUTHOR) vanessacuidador@gmail.com, Cruz, Marlon da Palma1 (AUTHOR), Mello, Dominique Cavalcanti1 (AUTHOR), Oliveira, Ana Paula Ligeiro de1 (AUTHOR), Martins, Rodrigo Álvaro Brandão Lopes2 (AUTHOR), Longo, Leonardo3 (AUTHOR), Parizotto, Nivaldo Antonio4 (AUTHOR), Marcos, Rodrigo Labat1 (AUTHOR) |
| Source: | Lasers in Medical Science. 10/27/2024, Vol. 39 Issue 1, p1-11. 11p. |
| Subjects: | Inflammatory bowel diseases, Crohn's disease, Photobiomodulation therapy, Ulcerative colitis, Therapeutics |
| Abstract: | The complexity of the gastrointestinal system plays a crucial role in coordinating essential processes such as digestion, nutrient absorption, and waste elimination. inflammatory bowel diseases (IBD) pose significant treatment challenges due to their complex aetiology and varied symptoms. Conventional therapeutic approaches often involve pharmacological interventions, which may have side effects and limited efficacy. Photobiomodulation (PBM), also known as low-level light therapy, has emerged as a promising therapeutic or adjunctive alternative in the treatment of intestinal diseases. The search was conducted in the MEDLINE database via PubMed, SCOPUS, covering the period from 1990 to 2024. A total of 72 studies were selected, of which 9 focused on inflammatory bowel diseases IBD, including ulcerative colitis (UC) and Crohn's disease (CD). Among these studies, 1 was clinical protocol while eight experimental. The results showed that PBM has a significant positive effect in IBD studies in rats, with reduction of intestinal inflammation, improvement of mucosal integrity, and modulation of the immune response. However, no clinical studies were found necessary to obtain results and establish effective and safe treatment protocols. Nevertheless, PBM holds potential as a non-invasive and complementary therapeutic approach for managing IBD, offering new perspectives for the treatment of chronic intestinal diseases. Therefore, this brief review emphasizes the need to transition from preclinical research to clinical research on this topic and highlights the scarcity of clinical studies. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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