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Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy.

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Title: Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy.
Authors: Nguyen, Viet-Khang1 (AUTHOR) d000018133@cgu.edu.tw, Tsai, Shiao-Wen2 (AUTHOR) d000000608@cgu.edu.tw, Cho, I-Chun3,4 (AUTHOR) d000018305@cgu.edu.tw, Chao, Tsi-Chian3,5 (AUTHOR) chaot@gap.cgu.edu.tw, Hsiao, Ing-Tsung5 (AUTHOR), Huang, Hsiao-Chieh6 (AUTHOR) hsiaochieh@cgmh.org.tw, Liaw, Jiunn-Woei1,6,7 (AUTHOR) markliaw@mail.cgu.edu.tw
Source: Nanomaterials (2079-4991). Feb2025, Vol. 15 Issue 4, p317. 21p.
Subjects: Hot carriers, Reactive oxygen species, Gold nanoparticles, Femtosecond lasers, Radiation sources, Proton beams
Abstract: Gold nanoparticles (GNPs) have gained significant attention as multifunctional agents in biomedical applications, particularly for enhancing radiotherapy. Their advantages, including low toxicity, high biocompatibility, and excellent conductivity, make them promising candidates for improving treatment outcomes across various radiation sources, such as femtosecond lasers, X-rays, Cs-137, and proton beams. However, a deeper understanding of their precise mechanisms in radiotherapy is essential for maximizing their therapeutic potential. This review explores the role of GNPs in enhancing reactive oxygen species (ROS) generation through plasmon-induced hot electrons or radiation-induced secondary electrons, leading to cellular damage in organelles such as mitochondria and the cytoskeleton. This additional pathway enhances radiotherapy efficacy, offering new therapeutic possibilities. Furthermore, we discuss emerging trends and future perspectives, highlighting innovative strategies for integrating GNPs into radiotherapy. This comprehensive review provides insights into the mechanisms, applications, and potential clinical impact of GNPs in cancer treatment. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy.
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  Data: <searchLink fieldCode="AR" term="%22Nguyen%2C+Viet-Khang%22">Nguyen, Viet-Khang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> d000018133@cgu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Shiao-Wen%22">Tsai, Shiao-Wen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> d000000608@cgu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Cho%2C+I-Chun%22">Cho, I-Chun</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> d000018305@cgu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Chao%2C+Tsi-Chian%22">Chao, Tsi-Chian</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<i> chaot@gap.cgu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Hsiao%2C+Ing-Tsung%22">Hsiao, Ing-Tsung</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Hsiao-Chieh%22">Huang, Hsiao-Chieh</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> hsiaochieh@cgmh.org.tw</i><br /><searchLink fieldCode="AR" term="%22Liaw%2C+Jiunn-Woei%22">Liaw, Jiunn-Woei</searchLink><relatesTo>1,6,7</relatesTo> (AUTHOR)<i> markliaw@mail.cgu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Feb2025, Vol. 15 Issue 4, p317. 21p.
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  Data: <searchLink fieldCode="DE" term="%22Hot+carriers%22">Hot carriers</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Femtosecond+lasers%22">Femtosecond lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+sources%22">Radiation sources</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+beams%22">Proton beams</searchLink>
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  Data: Gold nanoparticles (GNPs) have gained significant attention as multifunctional agents in biomedical applications, particularly for enhancing radiotherapy. Their advantages, including low toxicity, high biocompatibility, and excellent conductivity, make them promising candidates for improving treatment outcomes across various radiation sources, such as femtosecond lasers, X-rays, Cs-137, and proton beams. However, a deeper understanding of their precise mechanisms in radiotherapy is essential for maximizing their therapeutic potential. This review explores the role of GNPs in enhancing reactive oxygen species (ROS) generation through plasmon-induced hot electrons or radiation-induced secondary electrons, leading to cellular damage in organelles such as mitochondria and the cytoskeleton. This additional pathway enhances radiotherapy efficacy, offering new therapeutic possibilities. Furthermore, we discuss emerging trends and future perspectives, highlighting innovative strategies for integrating GNPs into radiotherapy. This comprehensive review provides insights into the mechanisms, applications, and potential clinical impact of GNPs in cancer treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano15040317
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        Text: English
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        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Gold nanoparticles
        Type: general
      – SubjectFull: Femtosecond lasers
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      – SubjectFull: Radiation sources
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      – SubjectFull: Proton beams
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      – TitleFull: Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy.
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            NameFull: Nguyen, Viet-Khang
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              M: 02
              Text: Feb2025
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              Y: 2025
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