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Tea drinking effectively improves symptoms of diabetes and prevents hepatorenal damage in mice.

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Title: Tea drinking effectively improves symptoms of diabetes and prevents hepatorenal damage in mice.
Authors: Zhao, Guangshan1,2 (AUTHOR), Yang, Lumin1 (AUTHOR), Ge, Yueting1,3 (AUTHOR), Qiu, Zhengyang2 (AUTHOR), Tang, Dong4 (AUTHOR), Fang, Yuying1 (AUTHOR), Ban, Qiuyan5 (AUTHOR), Yang, Chung S.1,6,7 (AUTHOR) csyang@pharmacy.rutgers.edu, Zhang, Jinsong1,7 (AUTHOR) zjs@ahau.edu.cn
Source: Food Research International. Jun2025, Vol. 211, pN.PAG-N.PAG. 1p.
Subjects: Type 1 diabetes, Type 2 diabetes, Aquaporins, Green tea, Hyperphagia, Aspartate aminotransferase
Abstract: Since type 2 diabetic patients often develop resistance to metformin as the progresses of diabetes, and almost all type 1 diabetic patients need receive insulin injection for hyperglycemia control. It is important to explore novel strategies with different mechanisms for diabetes management. Glucose-induced osmotic diuresis, known as polyuria, is the first clinical symptom in severe type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM). Drinking green tea or black tea effectively mitigates diabetic symptoms including polyuria, polydipsia, polyphagia and hyperglycemia in db/db mice via regulating renal aquaporin 2 and urine transporter A1 (UT-A1), in favor renal water reabsorption. This unique mechanism of action of tea could be useful for the treatment of diabetes in humans. In this study, we found that drinking Large-leaf yellow tea (LYT) for 5 weeks effectively ameliorated polyuria, polydipsia, polyphagia, hyperglycemia and excessive body weight gain, as well as upregulated renal water reabsorption associated proteins, including protein kinase C- alpha (PKC- α), membrane PKC- α and glycosylated UT-A1 in db/db mice. Four-days experiment were also confirmed the rapidly response of these proteins in favor renal water reabsorption and the amelioration of diabetic symptoms by LYT. We also found that green tea drinking effectively mitigated symptoms of diabetes in a mouse model for T1DM via upregulating these proteins. Moreover, green tea drinking prevented hepatorenal damage caused by hyperglycemia as suggested by the reduced levels of aspartate aminotransferase and creatinine in serum and the enhanced antioxidant defense system in liver and kidney. These results suggest the possible application of tea or tea constitutes in the clinical treatment of severe T2DM and T1DM, and the kidney is the target organ. [Display omitted] • Large-leaf yellow and green teas (LYT, GT) regulate renal water reabsorption proteins. • LYT drinking still alleviates diabetic symptoms in mice while metformin is ineffective. • LYT and GT consumption prevents hepatorenal damage caused by hyperglycemia. • LYT and GT drinking is beneficial for patients with glucose-induced osmotic diuresis. [ABSTRACT FROM AUTHOR]
Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Tea drinking effectively improves symptoms of diabetes and prevents hepatorenal damage in mice.
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  Data: <searchLink fieldCode="AR" term="%22Zhao%2C+Guangshan%22">Zhao, Guangshan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Lumin%22">Yang, Lumin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ge%2C+Yueting%22">Ge, Yueting</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qiu%2C+Zhengyang%22">Qiu, Zhengyang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Dong%22">Tang, Dong</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+Yuying%22">Fang, Yuying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ban%2C+Qiuyan%22">Ban, Qiuyan</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Chung+S%2E%22">Yang, Chung S.</searchLink><relatesTo>1,6,7</relatesTo> (AUTHOR)<i> csyang@pharmacy.rutgers.edu</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jinsong%22">Zhang, Jinsong</searchLink><relatesTo>1,7</relatesTo> (AUTHOR)<i> zjs@ahau.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Research+International%22">Food Research International</searchLink>. Jun2025, Vol. 211, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Type+1+diabetes%22">Type 1 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Type+2+diabetes%22">Type 2 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Aquaporins%22">Aquaporins</searchLink><br /><searchLink fieldCode="DE" term="%22Green+tea%22">Green tea</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperphagia%22">Hyperphagia</searchLink><br /><searchLink fieldCode="DE" term="%22Aspartate+aminotransferase%22">Aspartate aminotransferase</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Since type 2 diabetic patients often develop resistance to metformin as the progresses of diabetes, and almost all type 1 diabetic patients need receive insulin injection for hyperglycemia control. It is important to explore novel strategies with different mechanisms for diabetes management. Glucose-induced osmotic diuresis, known as polyuria, is the first clinical symptom in severe type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM). Drinking green tea or black tea effectively mitigates diabetic symptoms including polyuria, polydipsia, polyphagia and hyperglycemia in db/db mice via regulating renal aquaporin 2 and urine transporter A1 (UT-A1), in favor renal water reabsorption. This unique mechanism of action of tea could be useful for the treatment of diabetes in humans. In this study, we found that drinking Large-leaf yellow tea (LYT) for 5 weeks effectively ameliorated polyuria, polydipsia, polyphagia, hyperglycemia and excessive body weight gain, as well as upregulated renal water reabsorption associated proteins, including protein kinase C- alpha (PKC- α), membrane PKC- α and glycosylated UT-A1 in db/db mice. Four-days experiment were also confirmed the rapidly response of these proteins in favor renal water reabsorption and the amelioration of diabetic symptoms by LYT. We also found that green tea drinking effectively mitigated symptoms of diabetes in a mouse model for T1DM via upregulating these proteins. Moreover, green tea drinking prevented hepatorenal damage caused by hyperglycemia as suggested by the reduced levels of aspartate aminotransferase and creatinine in serum and the enhanced antioxidant defense system in liver and kidney. These results suggest the possible application of tea or tea constitutes in the clinical treatment of severe T2DM and T1DM, and the kidney is the target organ. [Display omitted] • Large-leaf yellow and green teas (LYT, GT) regulate renal water reabsorption proteins. • LYT drinking still alleviates diabetic symptoms in mice while metformin is ineffective. • LYT and GT consumption prevents hepatorenal damage caused by hyperglycemia. • LYT and GT drinking is beneficial for patients with glucose-induced osmotic diuresis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.foodres.2025.116502
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Type 1 diabetes
        Type: general
      – SubjectFull: Type 2 diabetes
        Type: general
      – SubjectFull: Aquaporins
        Type: general
      – SubjectFull: Green tea
        Type: general
      – SubjectFull: Hyperphagia
        Type: general
      – SubjectFull: Aspartate aminotransferase
        Type: general
    Titles:
      – TitleFull: Tea drinking effectively improves symptoms of diabetes and prevents hepatorenal damage in mice.
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            NameFull: Zhao, Guangshan
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            NameFull: Yang, Lumin
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            NameFull: Ge, Yueting
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            NameFull: Qiu, Zhengyang
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            NameFull: Tang, Dong
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            NameFull: Fang, Yuying
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            NameFull: Ban, Qiuyan
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            NameFull: Yang, Chung S.
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            NameFull: Zhang, Jinsong
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            – D: 15
              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
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              Value: 09639969
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              Value: 211
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            – TitleFull: Food Research International
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