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3D Fe–MOFs mimick peroxidase to enable monitoring of ascorbic acid in rat brain following brain ischemia.

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Title: 3D Fe–MOFs mimick peroxidase to enable monitoring of ascorbic acid in rat brain following brain ischemia.
Authors: Chen, Jian-Mei1 (AUTHOR), Wang, Yu-Xin1 (AUTHOR), Zhou, Neng-Jing1 (AUTHOR), Ding, Yong-Qi1 (AUTHOR) dingyongqi@hbnu.edu.cn
Source: Microchemical Journal. Jun2025, Vol. 213, pN.PAG-N.PAG. 1p.
Subjects: Metal-organic frameworks, Cerebral ischemia, Vitamin C, Synthetic enzymes, Catalytic activity
Abstract: We synthesized a monometallic mimetic catalyst with peroxidase-like activity, referred to as a Fe–MOFs, which were subsequently developed for use as a bioanalytical platform for monitoring ascorbic acid (AA). [Display omitted] • Fe–MOFs showed great peroxidase-like activity and stability. • Decomposition of adsorbed H 2 O 2 at the FeII-O-Fe sites of Fe–MOF to generate OH. • A colorimetric sensor for the detection of AA was proposed. • Sensor for monitoring AA levels in rat brain following the cerebral calm/ischemia. The rational development of efficient nanozymes is important for construction of biosensors with high catalytic properties, and thus multifunctional structure and performance of metal organic frameworks (MOFs) with enzyme-like activity make them potential candidates. Herein, we prepared regular 3D concave octahedral Fe–MOFs nanozymes by a one-step solvothermal strategy, exhibiting excellent peroxidase-like catalytic activity. Mechanistic studies revealed that the peroxidase-like catalytic process in Fe–MOF involves H 2 O 2 adsorption (H 2 O 2ad) and rapid electron transfer at open FeII-O-Fe metal sites to generate hydroxyl radicals (OH), which catalyze the oxidation of TMB to the blue product TMBox. Moreover, a platform for the quantitative detection of ascorbic acid (AA) was developed based on the good catalytic activity and stability of Fe–MOFs nanozymes. The constructed colorimetric platform for Fe–MOFs has increased sensitivity for AA measurements, possessing a good linear range of 0.01–50 µM with detection limit of about 4.5 nM. Furthermore, the ability of Fe–MOFs nanozymes to be used for facile colorimetric visualization of cerebral AA in rat following brain ischemia procedure illustrates promising applications of this platform. [ABSTRACT FROM AUTHOR]
Copyright of Microchemical Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: 3D Fe–MOFs mimick peroxidase to enable monitoring of ascorbic acid in rat brain following brain ischemia.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Jian-Mei%22">Chen, Jian-Mei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yu-Xin%22">Wang, Yu-Xin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Neng-Jing%22">Zhou, Neng-Jing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ding%2C+Yong-Qi%22">Ding, Yong-Qi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dingyongqi@hbnu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Microchemical+Journal%22">Microchemical Journal</searchLink>. Jun2025, Vol. 213, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Metal-organic+frameworks%22">Metal-organic frameworks</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ischemia%22">Cerebral ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+C%22">Vitamin C</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+enzymes%22">Synthetic enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Catalytic+activity%22">Catalytic activity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We synthesized a monometallic mimetic catalyst with peroxidase-like activity, referred to as a Fe–MOFs, which were subsequently developed for use as a bioanalytical platform for monitoring ascorbic acid (AA). [Display omitted] • Fe–MOFs showed great peroxidase-like activity and stability. • Decomposition of adsorbed H 2 O 2 at the FeII-O-Fe sites of Fe–MOF to generate OH. • A colorimetric sensor for the detection of AA was proposed. • Sensor for monitoring AA levels in rat brain following the cerebral calm/ischemia. The rational development of efficient nanozymes is important for construction of biosensors with high catalytic properties, and thus multifunctional structure and performance of metal organic frameworks (MOFs) with enzyme-like activity make them potential candidates. Herein, we prepared regular 3D concave octahedral Fe–MOFs nanozymes by a one-step solvothermal strategy, exhibiting excellent peroxidase-like catalytic activity. Mechanistic studies revealed that the peroxidase-like catalytic process in Fe–MOF involves H 2 O 2 adsorption (H 2 O 2ad) and rapid electron transfer at open FeII-O-Fe metal sites to generate hydroxyl radicals (OH), which catalyze the oxidation of TMB to the blue product TMBox. Moreover, a platform for the quantitative detection of ascorbic acid (AA) was developed based on the good catalytic activity and stability of Fe–MOFs nanozymes. The constructed colorimetric platform for Fe–MOFs has increased sensitivity for AA measurements, possessing a good linear range of 0.01–50 µM with detection limit of about 4.5 nM. Furthermore, the ability of Fe–MOFs nanozymes to be used for facile colorimetric visualization of cerebral AA in rat following brain ischemia procedure illustrates promising applications of this platform. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Microchemical Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.microc.2025.113746
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Metal-organic frameworks
        Type: general
      – SubjectFull: Cerebral ischemia
        Type: general
      – SubjectFull: Vitamin C
        Type: general
      – SubjectFull: Synthetic enzymes
        Type: general
      – SubjectFull: Catalytic activity
        Type: general
    Titles:
      – TitleFull: 3D Fe–MOFs mimick peroxidase to enable monitoring of ascorbic acid in rat brain following brain ischemia.
        Type: main
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          Name:
            NameFull: Chen, Jian-Mei
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            NameFull: Wang, Yu-Xin
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            NameFull: Zhou, Neng-Jing
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            NameFull: Ding, Yong-Qi
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            – D: 01
              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
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              Value: 213
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