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The Use of Solid‐Phase Supports for Derivatization in Chromatography and Spectroscopy.

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Title: The Use of Solid‐Phase Supports for Derivatization in Chromatography and Spectroscopy.
Authors: Johnson, Mitchell E.1 johnsonm@duq.edu, Carpenter, Tara S.1
Source: Applied Spectroscopy Reviews. Oct-Dec2005, Vol. 40 Issue 4, p391-412. 22p.
Subjects: Chromatographic analysis, Spectrum analysis, Chemical reactions, Analytical chemistry, Fluorescence
Abstract: Derivatization, or chemical modification of analytes, is often required for species that are only weakly detectable by common spectroscopic methods. Derivatization is most commonly performed in homogeneous solution or using phase‐transfer catalyzed reactions. However, the use of solid phase supports for performing the same reactions has a number of advantages. The sample can be “cleaned up” on the same phase, eliminating interfering matrix components or excess reagent. The process naturally concentrates the analyte, providing higher sensitivity, but also, under favorable circumstances, provides for more efficient reactions relative to solutions of the same original concentration. This review explores the uses to which such supports have been put, primarily in fluorescence derivatization for chromatographic applications. Some of the considerations in applying these techniques are described, and they are shown to be an extremely useful format for derivatization. [ABSTRACT FROM AUTHOR]
Copyright of Applied Spectroscopy Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 18622134
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: The Use of Solid‐Phase Supports for Derivatization in Chromatography and Spectroscopy.
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  Data: <searchLink fieldCode="AR" term="%22Johnson%2C+Mitchell+E%2E%22">Johnson, Mitchell E.</searchLink><relatesTo>1</relatesTo><i> johnsonm@duq.edu</i><br /><searchLink fieldCode="AR" term="%22Carpenter%2C+Tara+S%2E%22">Carpenter, Tara S.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Applied+Spectroscopy+Reviews%22">Applied Spectroscopy Reviews</searchLink>. Oct-Dec2005, Vol. 40 Issue 4, p391-412. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Chromatographic+analysis%22">Chromatographic analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrum+analysis%22">Spectrum analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+reactions%22">Chemical reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Analytical+chemistry%22">Analytical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence%22">Fluorescence</searchLink>
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  Data: Derivatization, or chemical modification of analytes, is often required for species that are only weakly detectable by common spectroscopic methods. Derivatization is most commonly performed in homogeneous solution or using phase‐transfer catalyzed reactions. However, the use of solid phase supports for performing the same reactions has a number of advantages. The sample can be “cleaned up” on the same phase, eliminating interfering matrix components or excess reagent. The process naturally concentrates the analyte, providing higher sensitivity, but also, under favorable circumstances, provides for more efficient reactions relative to solutions of the same original concentration. This review explores the uses to which such supports have been put, primarily in fluorescence derivatization for chromatographic applications. Some of the considerations in applying these techniques are described, and they are shown to be an extremely useful format for derivatization. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Applied Spectroscopy Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/05704920500250334
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      – Code: eng
        Text: English
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        PageCount: 22
        StartPage: 391
    Subjects:
      – SubjectFull: Chromatographic analysis
        Type: general
      – SubjectFull: Spectrum analysis
        Type: general
      – SubjectFull: Chemical reactions
        Type: general
      – SubjectFull: Analytical chemistry
        Type: general
      – SubjectFull: Fluorescence
        Type: general
    Titles:
      – TitleFull: The Use of Solid‐Phase Supports for Derivatization in Chromatography and Spectroscopy.
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            NameFull: Johnson, Mitchell E.
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            NameFull: Carpenter, Tara S.
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              M: 10
              Text: Oct-Dec2005
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              Y: 2005
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              Value: 40
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            – TitleFull: Applied Spectroscopy Reviews
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