Optimizing Sunscreen Safety: The Impact of TiO 2 Particle Size on Toxicity and Biocompatibility.
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| Title: | Optimizing Sunscreen Safety: The Impact of TiO 2 Particle Size on Toxicity and Biocompatibility. |
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| Authors: | Maddaleno, Adriana S.1,2 (AUTHOR), Casellas, Clàudia2,3 (AUTHOR), Teixidó, Elisabet3 (AUTHOR), Guardia-Escote, Laia1,3 (AUTHOR), Vinardell, Maria Pilar1,2 (AUTHOR) mpvinardellmh@ub.edu, Mitjans, Montserrat1,2,3 (AUTHOR) montsemitjans@ub.edu |
| Source: | Nanomaterials (2079-4991). Jun2025, Vol. 15 Issue 12, p951. 20p. |
| Subjects: | Cytotoxins, Titanium dioxide, DNA damage, Sunscreens (Cosmetics), Skin cancer |
| Abstract: | The use of UV filters is a well-established strategy for preventing skin cancer and photoaging. Among inorganic filters, titanium dioxide (TiO2) provides excellent protection against both UVA and UVB radiation. Moreover, the use of such inorganic filters at the nano-sized scale has increased their acceptability because it ensures the cosmetically desired transparency in sunscreens that consumers demand. However, concerns remain regarding the potential toxicity of TiO2 nanoparticles, and discussion about their use in pharmaceuticals and cosmetics is still in progress. Their increased (bio)reactivity compared to bulk materials may lead to DNA damage. Furthermore, their capacity to cross dermal, respiratory, and gastrointestinal membranes remains a subject of debate. This study is therefore designed to assess and contrast the toxicological characteristics of a pair of commercially available titanium (IV) oxide sunscreens differing in particle size—microscale versus nanoscale. First, the morphology and hydrodynamic diameter of the TiO2 nanoparticles were characterized. Then, potential interactions and/or interferences of these nanoparticles with the methods used to evaluate cytotoxic behavior were studied. Finally, the hemocompatibility, cytotoxicity, phototoxicity, and genotoxicity of both micro- and nano-sized TiO2 were evaluated using human keratinocytes. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 186258349 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimizing Sunscreen Safety: The Impact of TiO 2 Particle Size on Toxicity and Biocompatibility. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Maddaleno%2C+Adriana+S%2E%22">Maddaleno, Adriana S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casellas%2C+Clàudia%22">Casellas, Clàudia</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teixidó%2C+Elisabet%22">Teixidó, Elisabet</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guardia-Escote%2C+Laia%22">Guardia-Escote, Laia</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vinardell%2C+Maria+Pilar%22">Vinardell, Maria Pilar</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> mpvinardellmh@ub.edu</i><br /><searchLink fieldCode="AR" term="%22Mitjans%2C+Montserrat%22">Mitjans, Montserrat</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> montsemitjans@ub.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jun2025, Vol. 15 Issue 12, p951. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cytotoxins%22">Cytotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Titanium+dioxide%22">Titanium dioxide</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+damage%22">DNA damage</searchLink><br /><searchLink fieldCode="DE" term="%22Sunscreens+%28Cosmetics%29%22">Sunscreens (Cosmetics)</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+cancer%22">Skin cancer</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The use of UV filters is a well-established strategy for preventing skin cancer and photoaging. Among inorganic filters, titanium dioxide (TiO2) provides excellent protection against both UVA and UVB radiation. Moreover, the use of such inorganic filters at the nano-sized scale has increased their acceptability because it ensures the cosmetically desired transparency in sunscreens that consumers demand. However, concerns remain regarding the potential toxicity of TiO2 nanoparticles, and discussion about their use in pharmaceuticals and cosmetics is still in progress. Their increased (bio)reactivity compared to bulk materials may lead to DNA damage. Furthermore, their capacity to cross dermal, respiratory, and gastrointestinal membranes remains a subject of debate. This study is therefore designed to assess and contrast the toxicological characteristics of a pair of commercially available titanium (IV) oxide sunscreens differing in particle size—microscale versus nanoscale. First, the morphology and hydrodynamic diameter of the TiO2 nanoparticles were characterized. Then, potential interactions and/or interferences of these nanoparticles with the methods used to evaluate cytotoxic behavior were studied. Finally, the hemocompatibility, cytotoxicity, phototoxicity, and genotoxicity of both micro- and nano-sized TiO2 were evaluated using human keratinocytes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=186258349 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano15120951 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 951 Subjects: – SubjectFull: Cytotoxins Type: general – SubjectFull: Titanium dioxide Type: general – SubjectFull: DNA damage Type: general – SubjectFull: Sunscreens (Cosmetics) Type: general – SubjectFull: Skin cancer Type: general Titles: – TitleFull: Optimizing Sunscreen Safety: The Impact of TiO 2 Particle Size on Toxicity and Biocompatibility. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Maddaleno, Adriana S. – PersonEntity: Name: NameFull: Casellas, Clàudia – PersonEntity: Name: NameFull: Teixidó, Elisabet – PersonEntity: Name: NameFull: Guardia-Escote, Laia – PersonEntity: Name: NameFull: Vinardell, Maria Pilar – PersonEntity: Name: NameFull: Mitjans, Montserrat IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 15 – Type: issue Value: 12 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
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