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Surfactant-Free Electrosprayed Alginate Beads for Oral Delivery of Hydrophobic Compounds.

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Title: Surfactant-Free Electrosprayed Alginate Beads for Oral Delivery of Hydrophobic Compounds.
Authors: Jeong, Hye-Seon1 (AUTHOR), Kim, Hyo-Jin1,2 (AUTHOR), Kang, Sung-Min1,2 (AUTHOR), Choi, Chang-Hyung1,2 (AUTHOR)
Source: Polymers (20734360). Aug2025, Vol. 17 Issue 15, p2098. 11p.
Subjects: Hydrophobic compounds, Oral drug administration, Controlled release preparations, Microencapsulation, Surface active agents, Hydrogels, Biocompatibility
Abstract: Oral delivery of hydrophobic compounds remains challenging due to their poor aqueous solubility and the potential toxicity associated with conventional surfactant-based emulsions. To address these issues, we present a surfactant-free encapsulation strategy using electrosprayed alginate hydrogel beads for the stable and controlled delivery of hydrophobic oils. Hydrophobic compounds were dispersed in high-viscosity alginate solutions without surfactants via ultrasonication, forming kinetically stable oil-in-water dispersions. These mixtures were electrosprayed into calcium chloride baths, yielding monodisperse hydrogel beads. Higher alginate concentrations improved droplet sphericity and suppressed phase separation by enhancing matrix viscosity. The resulting beads exhibited stimuli-responsive degradation and controlled release behavior in response to physiological ionic strength. Dense alginate networks delayed ion exchange and prolonged structural integrity, while elevated external ionic conditions triggered rapid disintegration and immediate payload release. This simple and scalable system offers a biocompatible platform for the oral delivery of lipophilic active compounds without the need for surfactants or complex fabrication steps. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Surfactant-Free Electrosprayed Alginate Beads for Oral Delivery of Hydrophobic Compounds.
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Aug2025, Vol. 17 Issue 15, p2098. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Hydrophobic+compounds%22">Hydrophobic compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+drug+administration%22">Oral drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+preparations%22">Controlled release preparations</searchLink><br /><searchLink fieldCode="DE" term="%22Microencapsulation%22">Microencapsulation</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+active+agents%22">Surface active agents</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink>
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  Data: Oral delivery of hydrophobic compounds remains challenging due to their poor aqueous solubility and the potential toxicity associated with conventional surfactant-based emulsions. To address these issues, we present a surfactant-free encapsulation strategy using electrosprayed alginate hydrogel beads for the stable and controlled delivery of hydrophobic oils. Hydrophobic compounds were dispersed in high-viscosity alginate solutions without surfactants via ultrasonication, forming kinetically stable oil-in-water dispersions. These mixtures were electrosprayed into calcium chloride baths, yielding monodisperse hydrogel beads. Higher alginate concentrations improved droplet sphericity and suppressed phase separation by enhancing matrix viscosity. The resulting beads exhibited stimuli-responsive degradation and controlled release behavior in response to physiological ionic strength. Dense alginate networks delayed ion exchange and prolonged structural integrity, while elevated external ionic conditions triggered rapid disintegration and immediate payload release. This simple and scalable system offers a biocompatible platform for the oral delivery of lipophilic active compounds without the need for surfactants or complex fabrication steps. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.3390/polym17152098
    Languages:
      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 2098
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      – SubjectFull: Hydrophobic compounds
        Type: general
      – SubjectFull: Oral drug administration
        Type: general
      – SubjectFull: Controlled release preparations
        Type: general
      – SubjectFull: Microencapsulation
        Type: general
      – SubjectFull: Surface active agents
        Type: general
      – SubjectFull: Hydrogels
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      – SubjectFull: Biocompatibility
        Type: general
    Titles:
      – TitleFull: Surfactant-Free Electrosprayed Alginate Beads for Oral Delivery of Hydrophobic Compounds.
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            NameFull: Jeong, Hye-Seon
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            NameFull: Kim, Hyo-Jin
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            NameFull: Kang, Sung-Min
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            NameFull: Choi, Chang-Hyung
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            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
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