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Evaluating vestibulo-ocular reflex gain characteristics with monocular video head impulse test across different age groups in a healthy population.

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Title: Evaluating vestibulo-ocular reflex gain characteristics with monocular video head impulse test across different age groups in a healthy population.
Authors: Zhang, Qin1,2,3 (AUTHOR), Xu, Mingwei1,2,3 (AUTHOR), Wu, Qiong1,2,3 (AUTHOR), Yao, Yuan1,2,3 (AUTHOR), Gong, Tianyu1,2,3 (AUTHOR), Chen, Jianyong1,2,3 (AUTHOR), Jin, Yulian1,2,3 (AUTHOR) jinyulian8548@xinhuamed.com.cn, Yang, Jun1,2,3 (AUTHOR) yangjun@xinhuamed.com.cn, Zhang, Qing1,2,3 (AUTHOR) zhangqing03@xinhuamed.com.cn
Source: Journal of Vestibular Research: Equilibrium & Orientation. Mar2026, Vol. 36 Issue 2, p69-77. 9p.
Subjects: Vestibulo-ocular reflex, Age groups, Eye tracking, Sex factors in disease, Semicircular canals, Reference values
Abstract: Objective: The study aims to assess the high-frequency Vestibulo-Ocular Reflex (VOR) gain across three pairs of semicircular canals using the EyeSeeCam device and to determine normative values. Methods: A total of 105 volunteers, aged 19 to 69 years with no history of vestibular disorders, were enrolled. This cohort included 50 males (mean age 41.11 ± 15.98) and 55 females (mean age 35.52 ± 15.07), with no statistically significant age difference between the genders (P = 0.078). Participants were categorized into six age brackets: 11–20, 21–30, 31–40, 41–50, 51–60, and 61–70. For each test, the recording device was consistently positioned on the left side of the goggles, and the tests were conducted by a right-handed operator. Results: The average regression gain for left anterior-right posterior canals (LARP) was 1.44 ± 0.19, significantly surpassing that of right anterior-left posterior canals (RALP) at 1.09 ± 0.13 (p < 0.001) and horizontal semicircular canals (HSC) at 1.11 ± 0.07 (p < 0.001). No significant difference was observed between the VOR gains of RALP and HSC (p = 0.1077). Additionally, VOR gain values did not show significant variation across different age groups. In a gender-based analysis, a marginally higher HSC gain was observed in females (1.13 ± 0.07) compared to males (1.11 ± 0.07; p = 0.042), while no significant gender disparity was noted for RALP gains (females: 1.09 ± 0.11; males: 1.10 ± 0.14; p = 0.641). Females exhibited significantly higher LARP gain values (1.49 ± 0.18) than males (1.41 ± 0.20; p = 0.002). Conclusion: This study underscores the stability of high-frequency VOR gain values across ages. However, it also reveals a significant asymmetry in vertical canal gains (LARP vs RALP), suggesting a possible vertical canals monocular directional preponderance. This finding highlights that normative values can be highly specific to the recording and testing protocol. Thus, laboratories should develop their own normative values, customized to their equipment and testing protocols. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Vestibular Research: Equilibrium & Orientation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluating vestibulo-ocular reflex gain characteristics with monocular video head impulse test across different age groups in a healthy population.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Qin%22&quot;&gt;Zhang, Qin&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xu%2C+Mingwei%22&quot;&gt;Xu, Mingwei&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Qiong%22&quot;&gt;Wu, Qiong&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yao%2C+Yuan%22&quot;&gt;Yao, Yuan&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gong%2C+Tianyu%22&quot;&gt;Gong, Tianyu&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Jianyong%22&quot;&gt;Chen, Jianyong&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jin%2C+Yulian%22&quot;&gt;Jin, Yulian&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; jinyulian8548@xinhuamed.com.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Jun%22&quot;&gt;Yang, Jun&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; yangjun@xinhuamed.com.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Qing%22&quot;&gt;Zhang, Qing&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; zhangqing03@xinhuamed.com.cn&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Vestibular+Research%3A+Equilibrium+%26+Orientation%22&quot;&gt;Journal of Vestibular Research: Equilibrium &amp; Orientation&lt;/searchLink&gt;. Mar2026, Vol. 36 Issue 2, p69-77. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vestibulo-ocular+reflex%22&quot;&gt;Vestibulo-ocular reflex&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Age+groups%22&quot;&gt;Age groups&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Eye+tracking%22&quot;&gt;Eye tracking&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sex+factors+in+disease%22&quot;&gt;Sex factors in disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Semicircular+canals%22&quot;&gt;Semicircular canals&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Reference+values%22&quot;&gt;Reference values&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The study aims to assess the high-frequency Vestibulo-Ocular Reflex (VOR) gain across three pairs of semicircular canals using the EyeSeeCam device and to determine normative values. Methods: A total of 105 volunteers, aged 19 to 69 years with no history of vestibular disorders, were enrolled. This cohort included 50 males (mean age 41.11 &#177; 15.98) and 55 females (mean age 35.52 &#177; 15.07), with no statistically significant age difference between the genders (P = 0.078). Participants were categorized into six age brackets: 11–20, 21–30, 31–40, 41–50, 51–60, and 61–70. For each test, the recording device was consistently positioned on the left side of the goggles, and the tests were conducted by a right-handed operator. Results: The average regression gain for left anterior-right posterior canals (LARP) was 1.44 &#177; 0.19, significantly surpassing that of right anterior-left posterior canals (RALP) at 1.09 &#177; 0.13 (p &lt; 0.001) and horizontal semicircular canals (HSC) at 1.11 &#177; 0.07 (p &lt; 0.001). No significant difference was observed between the VOR gains of RALP and HSC (p = 0.1077). Additionally, VOR gain values did not show significant variation across different age groups. In a gender-based analysis, a marginally higher HSC gain was observed in females (1.13 &#177; 0.07) compared to males (1.11 &#177; 0.07; p = 0.042), while no significant gender disparity was noted for RALP gains (females: 1.09 &#177; 0.11; males: 1.10 &#177; 0.14; p = 0.641). Females exhibited significantly higher LARP gain values (1.49 &#177; 0.18) than males (1.41 &#177; 0.20; p = 0.002). Conclusion: This study underscores the stability of high-frequency VOR gain values across ages. However, it also reveals a significant asymmetry in vertical canal gains (LARP vs RALP), suggesting a possible vertical canals monocular directional preponderance. This finding highlights that normative values can be highly specific to the recording and testing protocol. Thus, laboratories should develop their own normative values, customized to their equipment and testing protocols. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Journal of Vestibular Research: Equilibrium &amp; Orientation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1177/09574271251367672
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 69
    Subjects:
      – SubjectFull: Vestibulo-ocular reflex
        Type: general
      – SubjectFull: Age groups
        Type: general
      – SubjectFull: Eye tracking
        Type: general
      – SubjectFull: Sex factors in disease
        Type: general
      – SubjectFull: Semicircular canals
        Type: general
      – SubjectFull: Reference values
        Type: general
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      – TitleFull: Evaluating vestibulo-ocular reflex gain characteristics with monocular video head impulse test across different age groups in a healthy population.
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            NameFull: Zhang, Qin
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              Text: Mar2026
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              Y: 2026
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            – TitleFull: Journal of Vestibular Research: Equilibrium & Orientation
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