Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects.
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| Title: | Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects. |
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| Authors: | Yang, Shu-Ping1 (AUTHOR), Chen, Li-Li1 (AUTHOR), Liu, Xiao-Ning1 (AUTHOR), Hu, Bin-Yuan1 (AUTHOR), Li, Ke-Ming1 (AUTHOR), Cheng, Yong-Xian1 (AUTHOR) yxcheng@szu.edu.cn |
| Source: | Journal of Molecular Structure. May2026, Vol. 1360, pN.PAG-N.PAG. 1p. |
| Subjects: | Renal fibrosis, Immunosuppression, Age factors in disease, Spermidine, Natural products, Polyamines, T cells |
| Abstract: | • Spermine/spermidine derivatives (1 − 7) were isolated from Pheretima aspergillum. • Compound 1 shows dose-dependent protection against age-related renal fibrosis. • Compound 4 exhibited immunosuppressive effects on T cells. Pheretima aspergillum (E. Perrier), commonly known as the earthworm, is a widely utilized medicinal animal in China, renowned for its broad spectrum of pharmacological properties. In the present study, seven undescribed spermine and spermidine derivatives, pheraspermines A − G (1 − 7), along with one known analogue (8), were isolated from the Pheretima aspergillum. Notably, compound 8 was identified as a natural product for the first time. The structures of all compounds were elucidated using spectroscopic techniques, including UV, 1D/2D NMR, and HRESIMS. Biological evaluation revealed that compound 1 showed dose-dependent protection against age-related renal fibrosis, while compound 4 exhibited immunosuppressive effects on T cells by flow cytometric analysis. [Display omitted] [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 191887767 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yang%2C+Shu-Ping%22">Yang, Shu-Ping</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Li-Li%22">Chen, Li-Li</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Xiao-Ning%22">Liu, Xiao-Ning</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Bin-Yuan%22">Hu, Bin-Yuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Ke-Ming%22">Li, Ke-Ming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Yong-Xian%22">Cheng, Yong-Xian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yxcheng@szu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Structure%22">Journal of Molecular Structure</searchLink>. May2026, Vol. 1360, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Renal+fibrosis%22">Renal fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosuppression%22">Immunosuppression</searchLink><br /><searchLink fieldCode="DE" term="%22Age+factors+in+disease%22">Age factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Spermidine%22">Spermidine</searchLink><br /><searchLink fieldCode="DE" term="%22Natural+products%22">Natural products</searchLink><br /><searchLink fieldCode="DE" term="%22Polyamines%22">Polyamines</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: • Spermine/spermidine derivatives (1 − 7) were isolated from Pheretima aspergillum. • Compound 1 shows dose-dependent protection against age-related renal fibrosis. • Compound 4 exhibited immunosuppressive effects on T cells. Pheretima aspergillum (E. Perrier), commonly known as the earthworm, is a widely utilized medicinal animal in China, renowned for its broad spectrum of pharmacological properties. In the present study, seven undescribed spermine and spermidine derivatives, pheraspermines A − G (1 − 7), along with one known analogue (8), were isolated from the Pheretima aspergillum. Notably, compound 8 was identified as a natural product for the first time. The structures of all compounds were elucidated using spectroscopic techniques, including UV, 1D/2D NMR, and HRESIMS. Biological evaluation revealed that compound 1 showed dose-dependent protection against age-related renal fibrosis, while compound 4 exhibited immunosuppressive effects on T cells by flow cytometric analysis. [Display omitted] [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molstruc.2026.145616 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Renal fibrosis Type: general – SubjectFull: Immunosuppression Type: general – SubjectFull: Age factors in disease Type: general – SubjectFull: Spermidine Type: general – SubjectFull: Natural products Type: general – SubjectFull: Polyamines Type: general – SubjectFull: T cells Type: general Titles: – TitleFull: Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yang, Shu-Ping – PersonEntity: Name: NameFull: Chen, Li-Li – PersonEntity: Name: NameFull: Liu, Xiao-Ning – PersonEntity: Name: NameFull: Hu, Bin-Yuan – PersonEntity: Name: NameFull: Li, Ke-Ming – PersonEntity: Name: NameFull: Cheng, Yong-Xian IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00222860 Numbering: – Type: volume Value: 1360 Titles: – TitleFull: Journal of Molecular Structure Type: main |
| ResultId | 1 |
