Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects.
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| Title: | Spermine and spermidine derivatives from the earthworm Pheretima aspergillum: Protective role in age-related renal fibrosis and immunosuppressive effects. |
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| Authors: | Yang, Shu-Ping1 (AUTHOR), Chen, Li-Li1 (AUTHOR), Liu, Xiao-Ning1 (AUTHOR), Hu, Bin-Yuan1 (AUTHOR), Li, Ke-Ming1 (AUTHOR), Cheng, Yong-Xian1 (AUTHOR) yxcheng@szu.edu.cn |
| Source: | Journal of Molecular Structure. May2026, Vol. 1360, pN.PAG-N.PAG. 1p. |
| Subjects: | Renal fibrosis, Immunosuppression, Age factors in disease, Spermidine, Natural products, Polyamines, T cells |
| Abstract: | • Spermine/spermidine derivatives (1 − 7) were isolated from Pheretima aspergillum. • Compound 1 shows dose-dependent protection against age-related renal fibrosis. • Compound 4 exhibited immunosuppressive effects on T cells. Pheretima aspergillum (E. Perrier), commonly known as the earthworm, is a widely utilized medicinal animal in China, renowned for its broad spectrum of pharmacological properties. In the present study, seven undescribed spermine and spermidine derivatives, pheraspermines A − G (1 − 7), along with one known analogue (8), were isolated from the Pheretima aspergillum. Notably, compound 8 was identified as a natural product for the first time. The structures of all compounds were elucidated using spectroscopic techniques, including UV, 1D/2D NMR, and HRESIMS. Biological evaluation revealed that compound 1 showed dose-dependent protection against age-related renal fibrosis, while compound 4 exhibited immunosuppressive effects on T cells by flow cytometric analysis. [Display omitted] [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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