Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus.
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| Title: | Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. |
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| Authors: | Le, Joo Min1 (AUTHOR) joominlee@chosun.ac.kr, Choi, Kyong-Hoon2 (AUTHOR) solidchem@hanmail.net, Mi, Jeeeun3 (AUTHOR) iseeiget@naver.com, Kim, Ho-Joong4 (AUTHOR) hjkim@chosun.ac.kr, Jee, Jun-Pil5 (AUTHOR) Jee@chosun.ac.kr, Park, Bong Joo6 (AUTHOR) parkbj@kw.ac.kr |
| Source: | Nanomaterials (2079-4991). Nov2017, Vol. 7 Issue 11, p365. 10p. |
| Abstract: | In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,20 -azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria (Staphylococcus aureus: S. aureus), including several strains of methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria (Escherichia coli). The functionalized ZnO@GA nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 192773083 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Le%2C+Joo+Min%22">Le, Joo Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> joominlee@chosun.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Choi%2C+Kyong-Hoon%22">Choi, Kyong-Hoon</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> solidchem@hanmail.net</i><br /><searchLink fieldCode="AR" term="%22Mi%2C+Jeeeun%22">Mi, Jeeeun</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> iseeiget@naver.com</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Ho-Joong%22">Kim, Ho-Joong</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> hjkim@chosun.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Jee%2C+Jun-Pil%22">Jee, Jun-Pil</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> Jee@chosun.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Park%2C+Bong+Joo%22">Park, Bong Joo</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> parkbj@kw.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Nov2017, Vol. 7 Issue 11, p365. 10p. – Name: Abstract Label: Abstract Group: Ab Data: In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,20 -azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria (Staphylococcus aureus: S. aureus), including several strains of methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria (Escherichia coli). The functionalized ZnO@GA nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano7110365 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 365 Titles: – TitleFull: Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Le, Joo Min – PersonEntity: Name: NameFull: Choi, Kyong-Hoon – PersonEntity: Name: NameFull: Mi, Jeeeun – PersonEntity: Name: NameFull: Kim, Ho-Joong – PersonEntity: Name: NameFull: Jee, Jun-Pil – PersonEntity: Name: NameFull: Park, Bong Joo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 7 – Type: issue Value: 11 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
