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Optimization, validation and application of a novel multiresidue method for prioritization of contaminants of emerging concern in biosolids.

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Title: Optimization, validation and application of a novel multiresidue method for prioritization of contaminants of emerging concern in biosolids.
Authors: Barros, A.1 (AUTHOR), Castro, G.1 (AUTHOR), Ramil, M.1 (AUTHOR), Rodríguez, I.1 (AUTHOR) isaac.rodriguez@usc.es
Source: Microchemical Journal. Jun2026, Vol. 225, pN.PAG-N.PAG. 1p.
Subjects: Micropollutants, Emerging contaminants, Sewage sludge, Liquid chromatography-mass spectrometry, Drugs, Sewage disposal plants, Extraction techniques, Environmental risk assessment
Abstract: Biosolids generated during municipal wastewater treatment are a source of organic matter and essential macronutrients, making them valuable to increase the fertility of soils. However, they also contain variable concentrations of micropollutants, particularly pharmaceuticals, which can pose environmental risks. An analytical methodology based on QuEChERS extraction and LC-MS/MS analysis was optimized and applied to the determination of 59 micropollutants, with large variations in their polarities and different uses, in biosolids from sewage treatment plants (STPs). Extraction efficiencies above 80%, and moderate variations in the efficiency of electrospray ionization were achieved for most of the target analytes in biosolids from different STPs. The accuracy of the final method ranged from 80% to 120% for 57 out of 59 micropollutants, with limits of quantification between 1 and 5 ng g−1, except for chlorhexidine (50 ng g−1). Forty-nine pollutants showed detection frequencies above 70%, with thirty-six compounds quantified in 100% of biosolids from 27 STPs. Biocides and psychiatric drugs represented more than 75% of residues in biosolids, with average accumulated concentrations of 5149 and 2425 ng g−1 (dry weight, d.w.), respectively. Within the first group, the maximum concentrations of azithromycin and chlorhexidine stayed above 2300 ng g−1 and 11,000 ng g−1 d.w., respectively. Ecological risk assessment of biosolids-amended soils identified fifteen compounds whose potential leaching into aquatic environments warrants further investigation. Significative accumulation in biosolids of several pharmaceuticals listed in the Wastewater Directive must be considered together, with their residues in raw and treated wastewaters, to estimate their real removal at STPs. [Display omitted] • Effective extraction of multiclass pollutants from dewatered biosolids. • Prevalence of biocides, psychiatric and cardiovascular drugs. • Detection of several drugs designed to assess wastewater treatment efficiency. • Prioritization of drugs for detailed risk assessment in biosolid-amended soils. [ABSTRACT FROM AUTHOR]
Copyright of Microchemical Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Optimization, validation and application of a novel multiresidue method for prioritization of contaminants of emerging concern in biosolids.
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  Data: <searchLink fieldCode="AR" term="%22Barros%2C+A%2E%22">Barros, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castro%2C+G%2E%22">Castro, G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramil%2C+M%2E%22">Ramil, M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodríguez%2C+I%2E%22">Rodríguez, I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> isaac.rodriguez@usc.es</i>
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  Data: <searchLink fieldCode="JN" term="%22Microchemical+Journal%22">Microchemical Journal</searchLink>. Jun2026, Vol. 225, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Micropollutants%22">Micropollutants</searchLink><br /><searchLink fieldCode="DE" term="%22Emerging+contaminants%22">Emerging contaminants</searchLink><br /><searchLink fieldCode="DE" term="%22Sewage+sludge%22">Sewage sludge</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Sewage+disposal+plants%22">Sewage disposal plants</searchLink><br /><searchLink fieldCode="DE" term="%22Extraction+techniques%22">Extraction techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+risk+assessment%22">Environmental risk assessment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Biosolids generated during municipal wastewater treatment are a source of organic matter and essential macronutrients, making them valuable to increase the fertility of soils. However, they also contain variable concentrations of micropollutants, particularly pharmaceuticals, which can pose environmental risks. An analytical methodology based on QuEChERS extraction and LC-MS/MS analysis was optimized and applied to the determination of 59 micropollutants, with large variations in their polarities and different uses, in biosolids from sewage treatment plants (STPs). Extraction efficiencies above 80%, and moderate variations in the efficiency of electrospray ionization were achieved for most of the target analytes in biosolids from different STPs. The accuracy of the final method ranged from 80% to 120% for 57 out of 59 micropollutants, with limits of quantification between 1 and 5 ng g−1, except for chlorhexidine (50 ng g−1). Forty-nine pollutants showed detection frequencies above 70%, with thirty-six compounds quantified in 100% of biosolids from 27 STPs. Biocides and psychiatric drugs represented more than 75% of residues in biosolids, with average accumulated concentrations of 5149 and 2425 ng g−1 (dry weight, d.w.), respectively. Within the first group, the maximum concentrations of azithromycin and chlorhexidine stayed above 2300 ng g−1 and 11,000 ng g−1 d.w., respectively. Ecological risk assessment of biosolids-amended soils identified fifteen compounds whose potential leaching into aquatic environments warrants further investigation. Significative accumulation in biosolids of several pharmaceuticals listed in the Wastewater Directive must be considered together, with their residues in raw and treated wastewaters, to estimate their real removal at STPs. [Display omitted] • Effective extraction of multiclass pollutants from dewatered biosolids. • Prevalence of biocides, psychiatric and cardiovascular drugs. • Detection of several drugs designed to assess wastewater treatment efficiency. • Prioritization of drugs for detailed risk assessment in biosolid-amended soils. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Microchemical Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.microc.2026.118188
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Micropollutants
        Type: general
      – SubjectFull: Emerging contaminants
        Type: general
      – SubjectFull: Sewage sludge
        Type: general
      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Sewage disposal plants
        Type: general
      – SubjectFull: Extraction techniques
        Type: general
      – SubjectFull: Environmental risk assessment
        Type: general
    Titles:
      – TitleFull: Optimization, validation and application of a novel multiresidue method for prioritization of contaminants of emerging concern in biosolids.
        Type: main
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          Name:
            NameFull: Barros, A.
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            NameFull: Castro, G.
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            NameFull: Ramil, M.
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            NameFull: Rodríguez, I.
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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              Value: 0026265X
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              Value: 225
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            – TitleFull: Microchemical Journal
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