Structure–Property Relationships in Streptomycin Sulfate–Incorporated Bioactive Glass/Chitosan Composite Scaffold: Physicochemical and Antibacterial Insights.
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| Title: | Structure–Property Relationships in Streptomycin Sulfate–Incorporated Bioactive Glass/Chitosan Composite Scaffold: Physicochemical and Antibacterial Insights. |
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| Authors: | Gadallah, Abdelrahman G.1 (AUTHOR), Bhran, Ahmed A.1,2 (AUTHOR) aabahran@imamu.edu.sa, Farag, M. A.1,2 (AUTHOR), Abdraboh, A. S.2 (AUTHOR), Al-Esnawy, A. A.2 (AUTHOR) |
| Source: | Polymers (20734360). May2026, Vol. 18 Issue 10, p1251. 18p. |
| Subjects: | Streptomycin, Bioactive glasses, Biomimetic materials, Tissue engineering, Antibacterial agents, Controlled release drugs, Porous materials, Hydroxyapatite |
| Abstract: | In this study, a streptomycin sulfate-loaded bioactive glass/chitosan (STRS–BG/CH) composite scaffold was fabricated via an improved unidirectional freeze-drying method, with drug loadings of 20–40%. The scaffolds were investigated by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray analysis before and after in vitro testing. Antibacterial efficacy was evaluated against Gram-positive (Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Klebsiella pneumoniae, Escherichia coli) microorganisms via the agar diffusion method. The STRS–BG/CH scaffolds exhibited highly interconnected porous structures, prolonged antibacterial activity, and enhanced apatite-forming ability in vitro. Compared with bead-based carriers, scaffold-based systems provide enhanced structural integrity and interconnected porosity, which are advantageous for sustained drug release, apatite formation, and tissue integration. Accordingly, these multifunctional scaffolds may simultaneously provide localized antibacterial activity and potential relevance to bone tissue engineering applications. The prepared STRS–BG/CH scaffolds functioned as controlled release carriers for streptomycin sulfate while simultaneously maintaining antibacterial efficacy and bioactive performance. These results illustrate the importance of STRS–BG/CH scaffolds as a promising antibacterial bioactive scaffold system, warranting further biological investigation. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 194117852 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Structure–Property Relationships in Streptomycin Sulfate–Incorporated Bioactive Glass/Chitosan Composite Scaffold: Physicochemical and Antibacterial Insights. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gadallah%2C+Abdelrahman+G%2E%22">Gadallah, Abdelrahman G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhran%2C+Ahmed+A%2E%22">Bhran, Ahmed A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> aabahran@imamu.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Farag%2C+M%2E+A%2E%22">Farag, M. A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdraboh%2C+A%2E+S%2E%22">Abdraboh, A. S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al-Esnawy%2C+A%2E+A%2E%22">Al-Esnawy, A. A.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. May2026, Vol. 18 Issue 10, p1251. 18p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Streptomycin%22">Streptomycin</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+glasses%22">Bioactive glasses</searchLink><br /><searchLink fieldCode="DE" term="%22Biomimetic+materials%22">Biomimetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Porous+materials%22">Porous materials</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In this study, a streptomycin sulfate-loaded bioactive glass/chitosan (STRS–BG/CH) composite scaffold was fabricated via an improved unidirectional freeze-drying method, with drug loadings of 20–40%. The scaffolds were investigated by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray analysis before and after in vitro testing. Antibacterial efficacy was evaluated against Gram-positive (Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Klebsiella pneumoniae, Escherichia coli) microorganisms via the agar diffusion method. The STRS–BG/CH scaffolds exhibited highly interconnected porous structures, prolonged antibacterial activity, and enhanced apatite-forming ability in vitro. Compared with bead-based carriers, scaffold-based systems provide enhanced structural integrity and interconnected porosity, which are advantageous for sustained drug release, apatite formation, and tissue integration. Accordingly, these multifunctional scaffolds may simultaneously provide localized antibacterial activity and potential relevance to bone tissue engineering applications. The prepared STRS–BG/CH scaffolds functioned as controlled release carriers for streptomycin sulfate while simultaneously maintaining antibacterial efficacy and bioactive performance. These results illustrate the importance of STRS–BG/CH scaffolds as a promising antibacterial bioactive scaffold system, warranting further biological investigation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym18101251 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 1251 Subjects: – SubjectFull: Streptomycin Type: general – SubjectFull: Bioactive glasses Type: general – SubjectFull: Biomimetic materials Type: general – SubjectFull: Tissue engineering Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Porous materials Type: general – SubjectFull: Hydroxyapatite Type: general Titles: – TitleFull: Structure–Property Relationships in Streptomycin Sulfate–Incorporated Bioactive Glass/Chitosan Composite Scaffold: Physicochemical and Antibacterial Insights. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gadallah, Abdelrahman G. – PersonEntity: Name: NameFull: Bhran, Ahmed A. – PersonEntity: Name: NameFull: Farag, M. A. – PersonEntity: Name: NameFull: Abdraboh, A. S. – PersonEntity: Name: NameFull: Al-Esnawy, A. A. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 18 – Type: issue Value: 10 Titles: – TitleFull: Polymers (20734360) Type: main |
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